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Details

Stereochemistry RACEMIC
Molecular Formula C16H22N2O3
Molecular Weight 290.3581
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROCATEROL

SMILES

CC[C@]([H])([C@]([H])(c1ccc(c2c1ccc(n2)O)O)O)NC(C)C

InChI

InChIKey=FKNXQNWAXFXVNW-WBMJQRKESA-N
InChI=1S/C16H22N2O3/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20)/t12-,16+/m1/s1

HIDE SMILES / InChI

Molecular Formula C16H22N2O3
Molecular Weight 290.3581
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/894683

Procaterol is a beta2-adrenoreceptor agonist. It is a bronchodilator that may be administered orally or by aerosol inhalation for the treatment of dyspnea caused by bronchial asthma, chronic bronchitis, and pulmonary emphysema. The drug is not approved in the USA, but is available in Japan, Indonesia, and other countries worldwide.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P07550|||Q53GA6|||Q9UCZ3
Gene ID: 154.0
Gene Symbol: ADRB2
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
MEPTIN

Approved Use

For the treatment of dyspnea caused by bronchial asthma, chronic bronchitis, and pulmonary emphysema
Primary
MEPTIN

Approved Use

For the treatment of dyspnea caused by bronchial asthma, chronic bronchitis, and pulmonary emphysema.
Primary
MEPTIN

Approved Use

For the treatment of dyspnea caused by bronchial asthma, chronic bronchitis, and pulmonary emphysema.
PubMed

PubMed

TitleDatePubMed
Procaterol and terbutaline in bronchial asthma. A double-blind, placebo-controlled, cross-over study.
1985 Oct
A comparison of oral procaterol and albuterol in reversible airflow obstruction.
1988 Dec
Beta 3-adrenergic receptor-mediated lipolysis and oxygen consumption in brown adipocytes from cynomolgus monkeys.
1997 Feb
Beta2-adrenoceptors on the glial cells mediate the induction of interleukin-1beta mRNA in the rat brain.
1997 Oct 3
Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincter.
2003 May
The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors.
2010 Jul
Interactions between theophylline and salbutamol on cytokine release in human monocytes.
2010 Jul
Patents

Sample Use Guides

Meptin tablets: the usual adult dose is 50 µg (one tablet) once before bed or twice daily (in the morning and before bed) by the oral route. Meptin air: in general, for adults, inhale 2 puffs (20 mcg of active ingredient) at a time, and for children, inhale 1 puff (10 mcg of active ingredient) at a time. The dosage may be adjusted according to your disease, age, or symptoms. Strictly follow the instructed dosing schedule. The maximum dosage is restricted to 4 times daily (8 puffs for adults and 4 puffs for children).
Route of Administration: Other
To study the beta2-blocking activity of procaterol, a guinea pig tracheal test was performed. The trachea was excised from male guinea pigs. A spiral section of the trachea was prepared and suspended in a 30-ml tissue bath. The condition of the tracheal muscle was monitored by isometric recordings using force transducers. Phentolamine was added to the bath fluid 15 min before induction of contraction with the test compound to block alpha-adrenergic receptors. ED50 for procaterol was 11 nM.
Substance Class Chemical
Created
by admin
on Sat Jun 26 13:28:36 UTC 2021
Edited
by admin
on Sat Jun 26 13:28:36 UTC 2021
Record UNII
X7I3EMM5K0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROCATEROL
INN   MI   WHO-DD  
INN  
Official Name English
PROCATEROL [INN]
Common Name English
(+/-)-ERYTHRO-8-HYDROXY-5-(1-HYDROXY-2-(ISOPROPYLAMINO)BUTYL)CARBOSTYRIL
Common Name English
2(1H)-QUINOLINONE, 8-HYDROXY-5-(1-HYDROXY-2-((1-METHYLETHYL)AMINO)BUTYL)-, (R*,S*)-
Common Name English
PROCATEROL [MI]
Common Name English
PROCATEROL [JAN]
Common Name English
PROCATEROL [WHO-DD]
Common Name English
MEPTIN
Brand Name English
Classification Tree Code System Code
WHO-VATC QR03AC16
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
WHO-ATC R03CC08
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
WHO-ATC R03AC16
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
WHO-VATC QR03CC08
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
Code System Code Type Description
EVMPD
SUB10058MIG
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
ChEMBL
CHEMBL160519
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
DRUG CENTRAL
2273
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
ECHA (EC/EINECS)
276-590-0
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
MERCK INDEX
M9147
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY Merck Index
IUPHAR
3464
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
INN
4259
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
PUBCHEM
688563
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
CAS
72332-33-3
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
DRUG BANK
DB01366
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
NCI_THESAURUS
C170351
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
RXCUI
34530
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY RxNorm
MESH
D017265
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
EPA CompTox
72332-33-3
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
FDA UNII
X7I3EMM5K0
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
WIKIPEDIA
PROCATEROL
Created by admin on Sat Jun 26 13:28:36 UTC 2021 , Edited by admin on Sat Jun 26 13:28:36 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
SHORT-ACTING
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY