CARPRONIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H18NO2
Molecular Weight	160.234
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)CCC[N+](C)(C)C

InChI

InChIKey=XQSLKIBWQSTAGK-UHFFFAOYSA-N

InChI=1S/C8H18NO2/c1-9(2,3)7-5-6-8(10)11-4/h5-7H2,1-4H3/q+1

HIDE SMILES / InChI

Molecular Formula	C8H18NO2
Molecular Weight	160.234
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/16543627
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/22171995 and http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602

Carpronium chloride is a hair growth reagent with a vasodilatory action. In vivo studies indicated that carpronium chloride achieved dilatation of vascular smooth muscle in the microcirculation of rats. FUROZIN SOLUTION 5% (active ingredient Carpronium chloride) has local vasodilating effect and hair growth stimulatory effect to improve alopecia and vitiligo. It is usually used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 160 Target ID: CHEMBL2094109 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01175	Agonist 2678

Conditions

Condition	Modality	Highest Phase	Product
Hair loss 5 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602	Preventing	Approved 8429	FUROZIN SOLUTION 5% Approved Use Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.
Seborrhea sicca 3 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602	Primary	Approved 8429	FUROZIN SOLUTION 5% Approved Use Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.
Vitiligo 9 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602	Primary	Approved 8429	FUROZIN SOLUTION 5% Approved Use Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

For alopecia and seborrhea sicca: In general, apply appropriate amount of the medicine to the affected area; or sprinkle the medicine on the whole scalp; twice to 3 times daily, and gently massage the head. For vitiligo vulgaris: In general, apply appropriate amount of the medicine to the affected area, 3 to 4 times daily.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:08:47 GMT 2023` Edited by `admin` on `Fri Dec 15 17:08:47 GMT 2023`
Record UNII	X6UK728GLZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CARPRONIUM

Common Name

English

CARPRONIUM ION

Common Name

English

CARPRONIUM CATION

Common Name

English

(3-CARBOXYPROPYL)TRIMETHYLAMMONIUM, METHYL ESTER

Common Name

English

Carpronium [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796