CARPRONIUM CHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H18NO2.Cl
Molecular Weight	195.687
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].COC(=O)CCC[N+](C)(C)C

InChI

InChIKey=RZMKWKZIJJNSLQ-UHFFFAOYSA-M

InChI=1S/C8H18NO2.ClH/c1-9(2,3)7-5-6-8(10)11-4;/h5-7H2,1-4H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula	C8H18NO2
Molecular Weight	160.234
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/16543627
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/22171995 and http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602

Carpronium chloride is a hair growth reagent with a vasodilatory action. In vivo studies indicated that carpronium chloride achieved dilatation of vascular smooth muscle in the microcirculation of rats. FUROZIN SOLUTION 5% (active ingredient Carpronium chloride) has local vasodilating effect and hair growth stimulatory effect to improve alopecia and vitiligo. It is usually used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 160 Target ID: CHEMBL2094109 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01175	Agonist 2678

Conditions

Condition	Modality	Highest Phase	Product
Hair loss 5 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602	Preventing	Approved 8429	FUROZIN SOLUTION 5% Approved Use Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.
Seborrhea sicca 3 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602	Primary	Approved 8429	FUROZIN SOLUTION 5% Approved Use Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.
Vitiligo 9 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602	Primary	Approved 8429	FUROZIN SOLUTION 5% Approved Use Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.

PubMed

Title	Date	PubMed
Seventeen cases of alopecia areata: combination of SADBE topical immunotherapy with other therapies.	2002 Oct	12433000
Topical immunotherapy in alopecia areata.	2010 Jan	21188022

Patents

Sample Use Guides

In Vivo Use Guide

For alopecia and seborrhea sicca: In general, apply appropriate amount of the medicine to the affected area; or sprinkle the medicine on the whole scalp; twice to 3 times daily, and gently massage the head. For vitiligo vulgaris: In general, apply appropriate amount of the medicine to the affected area, 3 to 4 times daily.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:14:39 GMT 2023` Edited by `admin` on `Fri Dec 15 16:14:39 GMT 2023`
Record UNII	1R01BKB74A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CARPRONIUM CHLORIDE

Official Name

English

FUROZIN

Brand Name

English

CARPRONIUM CHLORIDE [MI]

Common Name

English

CARPRONIUM CHLORIDE [INCI]

Common Name

English

Carpronium chloride [WHO-DD]

Common Name

English

ACTINAMIN

Brand Name

English

carpronium chloride [INN]

Common Name

English

(3-CARBOXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE, METHYL ESTER

Common Name

English

CARPRONIUM CHLORIDE [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796