Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C6H12O6 |
Molecular Weight | 180.1559 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O
InChI
InChIKey=GZCGUPFRVQAUEE-KCDKBNATSA-N
InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6-/m0/s1
Molecular Formula | C6H12O6 |
Molecular Weight | 180.1559 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Galactose, a monosaccharide sugar, is a key source of energy and is an important compound for early human development. Galactose is present in dairy products, the pectin of some fruits, vegetables, and some herbs. Children get most of their dietary galactose from milk. D-galactose is freely available in health food stores and is promoted for stimulating the immune system and improving gut motility in healthy individuals. Galactose as a part of food supplement participates in phase II of clinical trials for congenital disorders of glycosylation (CDG) patients. CDG is a group of more than 130 inborn errors of metabolism affecting N-linked, O-linked protein and lipid-linked glycosylation. In addition, monosaccharide is used in clinical trials phase I in patients with focal segmental glomerulosclerosis (FSGS), where the galactose lowers the level of a circulating factors that increase glomerular permeability to albumin in patients with resistant FSGS.
Approval Year
PubMed
Title | Date | PubMed |
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Synthesis and evaluation of novel fluorogenic substrates for the detection of bacterial beta-galactosidase. | 2001 Dec |
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In vivo fucosylation of lacto-N-neotetraose and lacto-N-neohexaose by heterologous expression of Helicobacter pylori alpha-1,3 fucosyltransferase in engineered Escherichia coli. | 2001 Jun |
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[Study of ABO blood group secretor type alpha(1,2)-fucosyltransferase gene polymorphism in Chinese]. | 2002 |
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Lack of consistency in the associations of Helicobacter pylori seropositivity with Se and Le polymorphisms among Japanese. | 2002 |
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Assignment of FUT8 to chicken chromosome band 5q1.4 and to human chromosome 14q23.2-->q24.1 by in situ hybridization. Conserved and compared synteny between human and chicken. | 2002 |
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Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation. | 2002 |
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Partial identification by site-directed mutagenesis of a cell growth inhibitory site on the human galectin-1 molecule. | 2002 |
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Transfection of the nm23-H1 gene into human hepatocarcinoma cell line inhibits the expression of sialyl Lewis X, alpha1,3 fucosyltransferase VII, and metastatic potential. | 2002 Apr |
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Human NK cell-mediated cytotoxicity triggered by CD86 and Gal alpha 1,3-Gal is inhibited in genetically modified porcine cells. | 2002 Apr 15 |
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IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. | 2002 Apr 15 |
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Binding of enzyme IIAGlc, a component of the phosphoenolpyruvate:sugar phosphotransferase system, to the Escherichia coli lactose permease. | 2002 Apr 30 |
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The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells. | 2002 Aug |
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Synthesis and evaluation of transition-state analogue inhibitors of alpha-1,3-fucosyltransferase. | 2002 Aug 16 |
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Expression of histo-blood group A antigen increases resistance to apoptosis and facilitates escape from immune control of rat colon carcinoma cells. | 2002 Dec |
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Discordant expression of selectin ligands and sialyl Lewis x-related epitopes on murine myeloid cells. | 2002 Dec 15 |
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The alpha (1,3)-fucosyltransferase Fuc-TIV, but not Fuc-TVII, generates sialyl Lewis X-like epitopes preferentially on glycolipids. | 2002 Dec 6 |
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Two glycosylation alterations of mouse intestinal mucins due to infection caused by the parasite Nippostrongylus brasiliensis. | 2002 Jan |
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The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins. | 2002 Jan |
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Transgenic pigs designed to express human CD59 and H-transferase to avoid humoral xenograft rejection. | 2002 Jan |
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The cytosolic and transmembrane domains of the beta 1,6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgi-targeting determinant. | 2002 Jan |
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Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile. | 2002 Jun |
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Alpha1,4-fucosyltransferase activity: a significant function in the primate lineage has appeared twice independently. | 2002 Jun |
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Detection of pigs resistant to post-weaning diarrhoea, oedema disease and porcine stress syndrome by allele-specific polymerase chain reaction. | 2002 Jun |
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Increased thermosensitivity of mouse colorectal carcinoma cells transfected with human FUT1 gene. | 2002 Jun 28 |
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Enzymatic synthesis of oligosaccharide containing Le(x) unit by using partially purified chicken serum. | 2002 Mar |
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Absorption of anti-blood group A antibodies on P-selectin glycoprotein ligand-1/immunoglobulin chimeras carrying blood group A determinants: core saccharide chain specificity of the Se and H gene encoded alpha1,2 fucosyltransferases in different host cells. | 2002 Mar |
|
Biosynthesis of the carbohydrate antigenic determinants, Globo H, blood group H, and Lewis b: a role for prostate cancer cell alpha1,2-L-fucosyltransferase. | 2002 Mar |
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Fucosyltransferase VII-deficient mice with defective E-, P-, and L-selectin ligands show impaired CD4+ and CD8+ T cell migration into the skin, but normal extravasation into visceral organs. | 2002 Mar 1 |
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Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues. | 2002 Mar 18 |
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Contribution of selectin ligands to eosinophil recruitment into the skin of patients with atopic dermatitis. | 2002 May |
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Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. | 2002 Nov |
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[Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium]. | 2002 Nov |
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Anthocyanin composition of the fruit of Coriaria myrtifolia L. | 2002 Nov-Dec |
|
Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified. | 2002 Oct |
|
Polymorphonuclear leukocytes from individuals carrying the G329A mutation in the alpha 1,3-fucosyltransferase VII gene (FUT7) roll on E- and P-selectins. | 2002 Oct 1 |
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Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. | 2002 Oct 15 |
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Molecular cloning and characterization of a novel alpha 1,2-fucosyltransferase (CE2FT-1) from Caenorhabditis elegans. | 2002 Oct 18 |
|
A new geniculatoside from aerial parts of Euphorbia geniculata Linn. | 2002 Sep |
|
Enzyme kinetics, substitutable resources and competition: from biochemistry to frequency-dependent selection in lac. | 2002 Sep |
|
Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury. | 2002 Sep 1 |
|
CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells. | 2002 Sep 1 |
|
Distinct sulfation requirements of selectins disclosed using cells that support rolling mediated by all three selectins under shear flow. L-selectin prefers carbohydrate 6-sulfation totyrosine sulfation, whereas p-selectin does not. | 2002 Sep 6 |
|
Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion. | 2003 Apr 11 |
|
Campylobacter jejuni binds intestinal H(O) antigen (Fuc alpha 1, 2Gal beta 1, 4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection. | 2003 Apr 18 |
|
Expression levels of H-type alpha(1,2)-fucosyltransferase gene and histo-blood group ABO gene corresponding to hematopoietic cell differentiation. | 2003 Jan |
|
Delayed rejection of porcine cartilage is averted by transgenic expression of alpha1,2-fucosyltransferase. | 2003 Jan |
|
N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin. | 2003 Jan 15 |
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C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer. | 2003 Jun 13 |
|
Immunobiological features of the galactoside lectin L-Lc isolated from the Argentine mistletoe Ligaria cuneifolia. | 2003 Mar |
|
Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element. | 2003 May 1 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:05:42 UTC 2023
by
admin
on
Fri Dec 15 15:05:42 UTC 2023
|
Record UNII |
X2RN3Q8DNE
|
Record Status |
Validated (UNII)
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Record Version |
|
-
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Classification Tree | Code System | Code | ||
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LOINC |
54085-6
Created by
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WHO-ATC |
V04CE01
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LOINC |
2308-5
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DSLD |
3828 (Number of products:21)
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FDA ORPHAN DRUG |
666818
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WHO-VATC |
QV04CE01
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NCI_THESAURUS |
C68479
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LOINC |
49219-9
Created by
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LOINC |
2306-9
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LOINC |
51594-0
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LOINC |
25426-8
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LOINC |
2309-3
Created by
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CFR |
21 CFR 862.1310
Created by
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LOINC |
25102-5
Created by
admin on Fri Dec 15 15:05:42 UTC 2023 , Edited by admin on Fri Dec 15 15:05:42 UTC 2023
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WHO-ATC |
V08DA02
Created by
admin on Fri Dec 15 15:05:42 UTC 2023 , Edited by admin on Fri Dec 15 15:05:42 UTC 2023
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WHO-VATC |
QV08DA02
Created by
admin on Fri Dec 15 15:05:42 UTC 2023 , Edited by admin on Fri Dec 15 15:05:42 UTC 2023
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LOINC |
34310-3
Created by
admin on Fri Dec 15 15:05:42 UTC 2023 , Edited by admin on Fri Dec 15 15:05:42 UTC 2023
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LOINC |
2307-7
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admin on Fri Dec 15 15:05:42 UTC 2023 , Edited by admin on Fri Dec 15 15:05:42 UTC 2023
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LOINC |
2310-1
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LOINC |
54084-9
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LOINC |
34311-1
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LOINC |
15071-4
Created by
admin on Fri Dec 15 15:05:42 UTC 2023 , Edited by admin on Fri Dec 15 15:05:42 UTC 2023
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LOINC |
13744-8
Created by
admin on Fri Dec 15 15:05:42 UTC 2023 , Edited by admin on Fri Dec 15 15:05:42 UTC 2023
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Code System | Code | Type | Description | ||
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X2RN3Q8DNE
Created by
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GALACTOSE
Created by
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3037556
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X2RN3Q8DNE
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59-23-4
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19217-07-3
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ALTERNATIVE | |||
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CHEMBL1233058
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DTXSID0023088
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LL-31(A)
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SUB39500
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C68482
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10257-28-0
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ALTERNATIVE | |||
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233-595-2
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3646-73-9
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ALTERNATIVE | |||
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1271
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PRIMARY | |||
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m5635
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PRIMARY | Merck Index | ||
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D005690
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200-416-4
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8102
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100000092038
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DB11735
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SUB12506MIG
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4139
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1287700
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28260
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4626
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12936
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PRIMARY |
Related Record | Type | Details | ||
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SOLVATE->ANHYDROUS |
Related Record | Type | Details | ||
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METABOLITE -> PARENT |
In people with galactokinase deficiency, a form of galactosemia, excess dulcitol forms in the lens of the eye leading to cataracts.
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Related Record | Type | Details | ||
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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Related Record | Type | Details | ||
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ACTIVE MOIETY |