Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C6H12O6.H2O |
| Molecular Weight | 198.1712 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O
InChI
InChIKey=SPFMQWBKVUQXJV-NQZVPSPJSA-N
InChI=1S/C6H12O6.H2O/c7-1-3(9)5(11)6(12)4(10)2-8;/h1,3-6,8-12H,2H2;1H2/t3-,4+,5+,6-;/m0./s1
| Molecular Formula | C6H12O6 |
| Molecular Weight | 180.1559 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Galactose, a monosaccharide sugar, is a key source of energy and is an important compound for early human development. Galactose is present in dairy products, the pectin of some fruits, vegetables, and some herbs. Children get most of their dietary galactose from milk. D-galactose is freely available in health food stores and is promoted for stimulating the immune system and improving gut motility in healthy individuals. Galactose as a part of food supplement participates in phase II of clinical trials for congenital disorders of glycosylation (CDG) patients. CDG is a group of more than 130 inborn errors of metabolism affecting N-linked, O-linked protein and lipid-linked glycosylation. In addition, monosaccharide is used in clinical trials phase I in patients with focal segmental glomerulosclerosis (FSGS), where the galactose lowers the level of a circulating factors that increase glomerular permeability to albumin in patients with resistant FSGS.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer. | 2003-06-13 |
|
| Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element. | 2003-05-01 |
|
| Campylobacter jejuni binds intestinal H(O) antigen (Fuc alpha 1, 2Gal beta 1, 4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection. | 2003-04-18 |
|
| Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion. | 2003-04-11 |
|
| Immunobiological features of the galactoside lectin L-Lc isolated from the Argentine mistletoe Ligaria cuneifolia. | 2003-03 |
|
| N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin. | 2003-01-15 |
|
| Expression levels of H-type alpha(1,2)-fucosyltransferase gene and histo-blood group ABO gene corresponding to hematopoietic cell differentiation. | 2003-01 |
|
| Delayed rejection of porcine cartilage is averted by transgenic expression of alpha1,2-fucosyltransferase. | 2003-01 |
|
| Anthocyanin composition of the fruit of Coriaria myrtifolia L. | 2002-12-24 |
|
| Discordant expression of selectin ligands and sialyl Lewis x-related epitopes on murine myeloid cells. | 2002-12-15 |
|
| The alpha (1,3)-fucosyltransferase Fuc-TIV, but not Fuc-TVII, generates sialyl Lewis X-like epitopes preferentially on glycolipids. | 2002-12-06 |
|
| Expression of histo-blood group A antigen increases resistance to apoptosis and facilitates escape from immune control of rat colon carcinoma cells. | 2002-12 |
|
| Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. | 2002-11 |
|
| [Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium]. | 2002-11 |
|
| Molecular cloning and characterization of a novel alpha 1,2-fucosyltransferase (CE2FT-1) from Caenorhabditis elegans. | 2002-10-18 |
|
| Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. | 2002-10-15 |
|
| Polymorphonuclear leukocytes from individuals carrying the G329A mutation in the alpha 1,3-fucosyltransferase VII gene (FUT7) roll on E- and P-selectins. | 2002-10-01 |
|
| Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified. | 2002-10 |
|
| Distinct sulfation requirements of selectins disclosed using cells that support rolling mediated by all three selectins under shear flow. L-selectin prefers carbohydrate 6-sulfation totyrosine sulfation, whereas p-selectin does not. | 2002-09-06 |
|
| Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury. | 2002-09-01 |
|
| CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells. | 2002-09-01 |
|
| A new geniculatoside from aerial parts of Euphorbia geniculata Linn. | 2002-09 |
|
| Enzyme kinetics, substitutable resources and competition: from biochemistry to frequency-dependent selection in lac. | 2002-09 |
|
| Synthesis and evaluation of transition-state analogue inhibitors of alpha-1,3-fucosyltransferase. | 2002-08-16 |
|
| The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells. | 2002-08 |
|
| Increased thermosensitivity of mouse colorectal carcinoma cells transfected with human FUT1 gene. | 2002-06-28 |
|
| Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile. | 2002-06 |
|
| Alpha1,4-fucosyltransferase activity: a significant function in the primate lineage has appeared twice independently. | 2002-06 |
|
| Detection of pigs resistant to post-weaning diarrhoea, oedema disease and porcine stress syndrome by allele-specific polymerase chain reaction. | 2002-06 |
|
| Contribution of selectin ligands to eosinophil recruitment into the skin of patients with atopic dermatitis. | 2002-05 |
|
| Binding of enzyme IIAGlc, a component of the phosphoenolpyruvate:sugar phosphotransferase system, to the Escherichia coli lactose permease. | 2002-04-30 |
|
| Human NK cell-mediated cytotoxicity triggered by CD86 and Gal alpha 1,3-Gal is inhibited in genetically modified porcine cells. | 2002-04-15 |
|
| IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. | 2002-04-15 |
|
| Transfection of the nm23-H1 gene into human hepatocarcinoma cell line inhibits the expression of sialyl Lewis X, alpha1,3 fucosyltransferase VII, and metastatic potential. | 2002-04 |
|
| Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues. | 2002-03-18 |
|
| Fucosyltransferase VII-deficient mice with defective E-, P-, and L-selectin ligands show impaired CD4+ and CD8+ T cell migration into the skin, but normal extravasation into visceral organs. | 2002-03-01 |
|
| Enzymatic synthesis of oligosaccharide containing Le(x) unit by using partially purified chicken serum. | 2002-03 |
|
| Absorption of anti-blood group A antibodies on P-selectin glycoprotein ligand-1/immunoglobulin chimeras carrying blood group A determinants: core saccharide chain specificity of the Se and H gene encoded alpha1,2 fucosyltransferases in different host cells. | 2002-03 |
|
| Biosynthesis of the carbohydrate antigenic determinants, Globo H, blood group H, and Lewis b: a role for prostate cancer cell alpha1,2-L-fucosyltransferase. | 2002-03 |
|
| Two glycosylation alterations of mouse intestinal mucins due to infection caused by the parasite Nippostrongylus brasiliensis. | 2002-01 |
|
| The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins. | 2002-01 |
|
| Transgenic pigs designed to express human CD59 and H-transferase to avoid humoral xenograft rejection. | 2002-01 |
|
| The cytosolic and transmembrane domains of the beta 1,6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgi-targeting determinant. | 2002-01 |
|
| [Study of ABO blood group secretor type alpha(1,2)-fucosyltransferase gene polymorphism in Chinese]. | 2002 |
|
| Lack of consistency in the associations of Helicobacter pylori seropositivity with Se and Le polymorphisms among Japanese. | 2002 |
|
| Assignment of FUT8 to chicken chromosome band 5q1.4 and to human chromosome 14q23.2-->q24.1 by in situ hybridization. Conserved and compared synteny between human and chicken. | 2002 |
|
| Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation. | 2002 |
|
| Partial identification by site-directed mutagenesis of a cell growth inhibitory site on the human galectin-1 molecule. | 2002 |
|
| Synthesis and evaluation of novel fluorogenic substrates for the detection of bacterial beta-galactosidase. | 2001-12 |
|
| In vivo fucosylation of lacto-N-neotetraose and lacto-N-neohexaose by heterologous expression of Helicobacter pylori alpha-1,3 fucosyltransferase in engineered Escherichia coli. | 2001-06 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:22:09 GMT 2025
by
admin
on
Mon Mar 31 22:22:09 GMT 2025
|
| Record UNII |
2C22T7DYYR
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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2C22T7DYYR
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1492336
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m5635
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72710723
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2C22T7DYYR
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64490-91-1
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ANHYDROUS->SOLVATE |
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