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Details

Stereochemistry RACEMIC
Molecular Formula C24H31NO
Molecular Weight 349.509
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIPIPANONE

SMILES

CCC(=O)C(CC(C)N1CCCCC1)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=SVDHSZFEQYXRDC-UHFFFAOYSA-N
InChI=1S/C24H31NO/c1-3-23(26)24(21-13-7-4-8-14-21,22-15-9-5-10-16-22)19-20(2)25-17-11-6-12-18-25/h4-5,7-10,13-16,20H,3,6,11-12,17-19H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C24H31NO
Molecular Weight 349.509
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: description was created based on several sources, including: http://www.druginfosys.com/drug.aspx?drugcode=252&type=1 | doi: 10.1007/978-3-540-68706-1_1823 | Miller, R.L. (2002) "The Encyclopedia of Addictive Drugs", p.130 Retrieved from https://books.google.ru/books?id=G7As-qawdzMC

Dipipanone are indicated for the management of moderate to severe pain in medical and surgical conditions in which morphine may be indicated. Dipipanone is related to methadone and can be substituted for assorted opioids. The severe or irreversible adverse effects of Dipipanone, which give rise to further complications, include hypotension, hypotension, hependence, agranulocytosis, ischemic colitis, generalized chorea, hypersensitivity hepatitis. It may interact badly with monoamine oxidase inhibitors, which are substances found in some antidepressants and other medication.

Originator

Ofner, P.|Walton, E.
4
Sources: DOI: 10.1039/JR9500002158

Approval Year

Unknown
127998
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Not Provided
505
Diconal

Approved Use

Dipipanone has no officially approved medical usage in the United States, but elsewhere it is used as a powerful pain reliever.
PubMed

PubMed

TitleDatePubMed
Psychotic symptoms after dipipanone.
1978 Aug 26
Prescription of diamorphine, dipipanone and cocaine in England and Wales.
1997 Sep
Patents

Patents

GB654975
4
JP2005520783A
40

Sample Use Guides

In Vivo Use Guide
The initial dose in all conditions is Dipipanone 10 mg (+ 30 mg Cyclizine) every 6 hours. It is seldom necessary to exceed a dose of 30 mg dipipanone given 6-hourly.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 16 19:58:38 UTC 2022
Edited
by admin
on Fri Dec 16 19:58:38 UTC 2022
Record UNII
X188638Y2V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIPIPANONE
INN   MI   WHO-DD  
INN  
Official Name English
4,4-DIPHENYL-6-PIPERIDINO-3-HEPTANONE
Systematic Name English
ACSCN-9622
Common Name English
PHENYLPIPERONE
Common Name English
2-(1-PIPERIDINO)-4,4-DIPHENYL-5-HEPTANONE
Common Name English
DIPIPANONE [MI]
Common Name English
PIPERIDYLAMIDONE
Common Name English
IDS-ND-017
Code English
dipipanone [INN]
Common Name English
DICONAL
Brand Name English
DL-4,4-DIPHENYL-6-PIPERIDINOHEPTAN-3-ONE
Common Name English
Dipipanone [WHO-DD]
Common Name English
6-PIPERIDINO-4,4-DIPHENYLHEPTAN-3-ONE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C241
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
NCI_THESAURUS C1506
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
NCI_THESAURUS C67413
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
DEA NO. 9622
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
Code System Code Type Description
CAS
856-87-1
Created by admin on Fri Dec 16 19:58:38 UTC 2022 , Edited by admin on Fri Dec 16 19:58:38 UTC 2022
SUPERSEDED
MERCK INDEX
M4647
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY Merck Index
MESH
C007527
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
ChEMBL
CHEMBL2111157
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
NCI_THESAURUS
C65426
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
EVMPD
SUB07215MIG
Created by admin on Fri Dec 16 19:58:38 UTC 2022 , Edited by admin on Fri Dec 16 19:58:38 UTC 2022
PRIMARY
CAS
27453-70-9
Created by admin on Fri Dec 16 19:58:38 UTC 2022 , Edited by admin on Fri Dec 16 19:58:38 UTC 2022
SUPERSEDED
WIKIPEDIA
DIPIPANONE
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
EPA CompTox
DTXSID50894759
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
FDA UNII
X188638Y2V
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
INN
465
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
ECHA (EC/EINECS)
207-399-2
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
DRUG CENTRAL
921
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
RXCUI
23405
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY RxNorm
DRUG BANK
DB01491
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
CAS
467-83-4
Created by admin on Fri Dec 16 19:58:38 UTC 2022 , Edited by admin on Fri Dec 16 19:58:38 UTC 2022
PRIMARY
PUBCHEM
13331
Created by admin on Fri Dec 16 19:58:39 UTC 2022 , Edited by admin on Fri Dec 16 19:58:39 UTC 2022
PRIMARY
Related Record Type Details
Structure of DIPIPANONE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
Structure of DIPIPANONE HYDROBROMIDE
SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
Structure of DIPIPANONE, (S)-
ENANTIOMER -> RACEMATE
Structure of DIPIPANONE, (R)-
ENANTIOMER -> RACEMATE
Structure of DIPIPANONE HYDROCHLORIDE MONOHYDRATE
SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
Related Record Type Details
Structure of DIPIPANONE
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