FLURADOLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H16FNOS
Molecular Weight	301.378
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNCCSC1=CC2=C(OC3=C1C=C(F)C=C3)C=CC=C2

InChI

InChIKey=LEBFQNREPOQDII-UHFFFAOYSA-N

InChI=1S/C17H16FNOS/c1-19-8-9-21-17-10-12-4-2-3-5-15(12)20-16-7-6-13(18)11-14(16)17/h2-7,10-11,19H,8-9H2,1H3

HIDE SMILES / InChI

Molecular Formula	C17H16FNOS
Molecular Weight	301.378
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: Annual Reports in Medicinal Chemistry, V 22, p. 26, retrieved from: https://books.google.ru/books?id=oJeTSJveeuAC&pg=PA26&lpg=PA26&dq=FLURADOLINE&source=bl&ots=9bsXOJDCLo&sig=ACfU3U3UR67bm4uZMCv8oAaWZ2axx0pLWw&hl=ru&sa=X&ved=2ahUKEwiP07bInc3jAhUByKYKHeenD5A4FBDoATACegQIBxAD#v=onepage&q=FLURADOLINE&f=false | https://www.ncbi.nlm.nih.gov/pubmed/25222675

Fluradoline (also known as HP-494), a centrally acting antinociceptive agent with antidepressant properties. Experiments on rodents have shown that fluradoline blocked the reuptake of NE, 5-HT, and DA in the brain. Besides, fluradoline was studied for the prevention of acute and chronic postsurgical pain.

Approval Year

PubMed

Title	Date	PubMed
Fluradoline and aspirin for orthopedic postoperative pain.	1987 May	3552360

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:20:05 UTC 2023` Edited by `admin` on `Fri Dec 15 17:20:05 UTC 2023`
Record UNII	WEP02A9K8C
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FLURADOLINE

Official Name

English

fluradoline [INN]

Common Name

English

ETHANAMINE, 2-((8-FLUORODIBENZ(B,F)OXEPIN-10-YL)THIO)-N-METHYL-

Systematic Name

English

Fluradoline [WHO-DD]

Common Name

English

2-((8-FLUORODIBENZ(B,F)OXEPIN-10-YL)THIO)-N-METHYLETHYLAMINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241