FLURADOLINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H16FNOS.ClH
Molecular Weight	337.839
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CNCCSC1=CC2=C(OC3=C1C=C(F)C=C3)C=CC=C2

InChI

InChIKey=HIOVQJCJNCRSCC-UHFFFAOYSA-N

InChI=1S/C17H16FNOS.ClH/c1-19-8-9-21-17-10-12-4-2-3-5-15(12)20-16-7-6-13(18)11-14(16)17;/h2-7,10-11,19H,8-9H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula	C17H16FNOS
Molecular Weight	301.378
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: Annual Reports in Medicinal Chemistry, V 22, p. 26, retrieved from: https://books.google.ru/books?id=oJeTSJveeuAC&pg=PA26&lpg=PA26&dq=FLURADOLINE&source=bl&ots=9bsXOJDCLo&sig=ACfU3U3UR67bm4uZMCv8oAaWZ2axx0pLWw&hl=ru&sa=X&ved=2ahUKEwiP07bInc3jAhUByKYKHeenD5A4FBDoATACegQIBxAD#v=onepage&q=FLURADOLINE&f=false | https://www.ncbi.nlm.nih.gov/pubmed/25222675

Fluradoline (also known as HP-494), a centrally acting antinociceptive agent with antidepressant properties. Experiments on rodents have shown that fluradoline blocked the reuptake of NE, 5-HT, and DA in the brain. Besides, fluradoline was studied for the prevention of acute and chronic postsurgical pain.

Approval Year

PubMed

Title	Date	PubMed
Imipramine reduces experimental pain.	1986 May	3523396
Fluradoline and aspirin for orthopedic postoperative pain.	1987 May	3552360

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:05:20 GMT 2023` Edited by `admin` on `Fri Dec 15 15:05:20 GMT 2023`
Record UNII	1STM5485LF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLURADOLINE HYDROCHLORIDE

Official Name

English

P-76-2494A

Code

English

P-762494A

Code

English

HP-494

Code

English

FLURADOLINE HYDROCHLORIDE [USAN]

Common Name

English

Fluradoline hydrochloride [WHO-DD]

Common Name

English

FLURADOLINE HCL

Common Name

English

2-[(8-Fluorodibenz[b,f]oxepin-10-yl)thio]-N-methylethylamine hydrochloride

Systematic Name

English

ETHANAMINE, 2-((8-FLUORODIBENZ(B,F)OXEPIN-10-YL)THIO)-N-METHYL-, HYDROCHLORIDE

Systematic Name

English

P 76 2494A

Code

English

HP 494

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C241