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Details

Stereochemistry RACEMIC
Molecular Formula C24H23N5O2
Molecular Weight 413.4717
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 3-HYDROXY-APATINIB, TRANS-

SMILES

O[C@@H]1CC[C@](C1)(C#N)C2=CC=C(NC(=O)C3=CC=CN=C3NCC4=CC=NC=C4)C=C2

InChI

InChIKey=PIRKQCNHXCEZRZ-YKSBVNFPSA-N
InChI=1S/C24H23N5O2/c25-16-24(10-7-20(30)14-24)18-3-5-19(6-4-18)29-23(31)21-2-1-11-27-22(21)28-15-17-8-12-26-13-9-17/h1-6,8-9,11-13,20,30H,7,10,14-15H2,(H,27,28)(H,29,31)/t20-,24+/m1/s1

HIDE SMILES / InChI

Molecular Formula C24H23N5O2
Molecular Weight 413.4717
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Substance Class Chemical
Created
by admin
on Wed Apr 02 09:08:45 GMT 2025
Edited
by admin
on Wed Apr 02 09:08:45 GMT 2025
Record UNII
WD3N2P38NO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
APATINIB METABOLITE M1-1
Preferred Name English
3-HYDROXY-APATINIB, TRANS-
Common Name English
3-PYRIDINECARBOXAMIDE, N-(4-((1R,3R)-1-CYANO-3-HYDROXYCYCLOPENTYL)PHENYL)-2-((4-PYRIDINYLMETHYL)AMINO)-, REL-
Systematic Name English
Code System Code Type Description
FDA UNII
WD3N2P38NO
Created by admin on Wed Apr 02 09:08:45 GMT 2025 , Edited by admin on Wed Apr 02 09:08:45 GMT 2025
PRIMARY
PUBCHEM
71664674
Created by admin on Wed Apr 02 09:08:45 GMT 2025 , Edited by admin on Wed Apr 02 09:08:45 GMT 2025
PRIMARY
CAS
1376710-38-1
Created by admin on Wed Apr 02 09:08:45 GMT 2025 , Edited by admin on Wed Apr 02 09:08:45 GMT 2025
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
IC50
BINDER->LIGAND
BINDING
TARGET -> INHIBITOR
IC50
Related Record Type Details
PARENT -> METABOLITE
MAJOR
PLASMA
PARENT -> METABOLITE
FECAL
PARENT -> METABOLITE
URINE
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC AT DAY 28

ONCE DAILY

ORAL ADMINISTRATION

DOSE

Tmax PHARMACOKINETIC DOSE

ORAL ADMINISTRATION

AT DAY 28

ONCE DAILY