Benzoyl peroxide

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H10O4
Molecular Weight	242.2268
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(OOC(=O)C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=OMPJBNCRMGITSC-UHFFFAOYSA-N

InChI=1S/C14H10O4/c15-13(11-7-3-1-4-8-11)17-18-14(16)12-9-5-2-6-10-12/h1-10H

HIDE SMILES / InChI

Molecular Formula	C14H10O4
Molecular Weight	242.2268
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/050557s025lbl.pdf

Benzoyl peroxide (BPO) is an organic compound in the peroxide family. It consists of two benzoyl groups bridged by a peroxide link. It is one of the most important organic peroxides in terms of applications and the scale of its production. Benzoyl peroxide is used as an acne treatment, for bleaching hair and teeth. Adverse reactions are: dryness and urticarial reaction, contact dermatitis, application site burning, application site irritation and skin irritation.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Acne vulgaris 34 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/050557s025lbl.pdf	Curative		Approved 8360	BENZAMYCIN PAK Approved Use Benzamycin pak (erythromycin 3%-benzoyl peroxide 5% topical gel) is indicated for the topical treatment of acne vulgaris. Launch Date 9.7528322E11

Doses

Dose	Population	Adverse events
10 % 2 times / day multiple, topical Highest studied dose Dose: 10 %, 2 times / day Route: topical Route: multiple Dose: 10 %, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/2948929	unhealthy, 20 years n = 25 Health Status: unhealthy Condition: acne vulgaris Age Group: 20 years Sex: M+F Population Size: 25 Sources: https://pubmed.ncbi.nlm.nih.gov/2948929	Other AEs: Peeling, Erythema... Other AEs: Peeling (moderate, 55%) Erythema (moderate, 30%) Sources: https://pubmed.ncbi.nlm.nih.gov/2948929

AEs

AE	Significance	Dose	Population
Erythema	moderate, 30%	10 % 2 times / day multiple, topical Highest studied dose Dose: 10 %, 2 times / day Route: topical Route: multiple Dose: 10 %, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/2948929	unhealthy, 20 years n = 25 Health Status: unhealthy Condition: acne vulgaris Age Group: 20 years Sex: M+F Population Size: 25 Sources: https://pubmed.ncbi.nlm.nih.gov/2948929
Peeling	moderate, 55%	10 % 2 times / day multiple, topical Highest studied dose Dose: 10 %, 2 times / day Route: topical Route: multiple Dose: 10 %, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/2948929	unhealthy, 20 years n = 25 Health Status: unhealthy Condition: acne vulgaris Age Group: 20 years Sex: M+F Population Size: 25 Sources: https://pubmed.ncbi.nlm.nih.gov/2948929

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY41810	https://www.001chemical.com/chem/94-36-0
3B Scientific (Wuhan) Corp	3B3-034757	http://www.3bsc.com/index/pro_info.php?id=56690
AA Blocks	AA0034FD	https://www.aablocks.com/goods/Goods/detail?id=AA0034FD
AHH Chemical co.,ltd	MT-47566	http://www.ahhchemical.com/product/MT-47566.html
AbMole Bioscience	M3247	http://www.abmole.com/products/benzoyl-peroxide.html
Acadechem	ACDS-033529	http://www.acadechemical.com/product/108228
Aceschem	ACS015568	https://www.aceschem.com/catalog/94-36-0.html
Achemica	ACMC-209u3h	http://www.achemica.com/prodinfo/?id=135288
Achemo Scientific Limited	AC-33026	http://www.achemo.com/product_view.asp?ID=37080
Achemtek	0104-015743	http://www.achemtek.com/94-36-0
Acros Organics	AC211780010	https://www.fishersci.com/shop/products/dibenzoyl-peroxide-75-remainder-water-acros-organics/AC211780010
Acros Organics	AC211780050	https://www.fishersci.com/shop/products/dibenzoyl-peroxide-75-remainder-water-acros-organics/AC211780050
Acros Organics	AC211781000	https://www.fishersci.com/shop/products/dibenzoyl-peroxide-75-remainder-water-acros-organics/AC211781000
Alfa Aesar	L13174	https://www.alfa.com/en/catalog/L13174/
Angene	AGN-PC-0JK7YQ	http://www.angenechemical.com/productshow/AGN-PC-0JK7YQ.html
Anward	ANW-43275	http://www.anward.com/pro_result/21336
Boerchem	BC220923	http://www.boerchem.com/?product_37413.html
BroadPharm	BP-21236	http://www.broadpharm.com/products/BP-21236/
ChemMol	49417090	http://www.chemmol.com/chemmol/49417090.html
ChemMol	99067093	http://www.chemmol.com/chemmol/99067093.html
ChemMol	99183620	http://www.chemmol.com/chemmol/99183620.html
Chemspace	CSSB00000069115	https://chem-space.com/CSSB00000069115
China MainChem Co., Ltd	94-36-0	https://www.mainchem.com/product/benzoyl-peroxide/
Clearsynth	CS-T-05285	https://www.clearsynth.com/en/CST05285.html
DC Chemicals	DC32195	http://www.dcchemicals.com//product_show-Benzoyl_Peroxide.html
Debye Scientific	DB-022598	http://www.debyesci.com/DB-022598.html
Fisher Chemical	B2741LB	https://www.fishersci.com/shop/products/benzoyl-peroxide-wet-certified-fisher-chemical/B2741LB
Glentham Life Sciences	GK7133	http://www.glentham.com/products/product/GK7133/
MolPort	MolPort-001-783-287	https://www.molport.com/shop/molecule-link/MolPort-001-783-287
Molcore	MC41810	https://www.molcore.com/product/94-36-0
Otava	3166196	https://search.otavachemicals.com/#!/search?query=3166196&type=code&base=dbb
Parchem	1501	http://www.parchem.com/chemical-supplier-distributor/Benzoyl-Peroxide-002863.aspx
Parchem	33599	http://www.parchem.com/chemical-supplier-distributor/Benzoyl-Peroxide-1--023599.aspx
Parchem	33600	http://www.parchem.com/chemical-supplier-distributor/Benzoyl-Peroxide-2--023600.aspx
Parchem	33601	http://www.parchem.com/chemical-supplier-distributor/Benzoyl-Peroxide-3--023601.aspx
Parchem	33602	http://www.parchem.com/chemical-supplier-distributor/Benzoyl-Peroxide-4--023602.aspx
Renno Tech	RP28518	http://www.rennotech.com/product_show.asp?id=34131
Shangyu Catsyn Co., Ltd.	SC10147	http://www.catsyn.com/product/94-36-0.html
Sigma-Aldrich	513431_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/513431?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	513466_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/513466?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	03-1565_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/031565?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	00213_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/00213?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	179981_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/179981?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S017872	http://www.sinfoobiotech.com/product/1021270
Smolecule	S520927	http://www.smolecule.com/products/s520927
Smolecule	S748764	https://www.smolecule.com/products/s748764
TCI (Tokyo Chemical Industry)	B3152	http://www.tcichemicals.com/eshop/en/us/commodity/B3152/index.html
THE BioTek	bt-262109	https://www.thebiotek.com/product/inhibitors/bt-262109
VladaChem	VL161705	https://www.vladachem.com/product.php?products=94-36-0
VladaChem	VL161708	https://www.vladachem.com/product.php?products=94-36-0
VladaChem	VL280548-100G	https://www.vladachem.com/product.php?products=94-36-0
Yuhao Chemical	LQ0235	http://www.chemyuhao.com/94-36-0.html
abcr GmbH	AB174217	http://www.abcr.com/shop/en/AB174217
iChemical	EBD40747	http://www.ichemical.com/products/94-36-0.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule	MCULE-5748985501	https://mcule.com/MCULE-5748985501/

PubMed

Title	Date	PubMed
Evaluation of certain food additives and contaminants.	2001	11588830
Oxidative targets in the stratum corneum. A new basis for antioxidative strategies.	2001	11509912
Syntheses, characterization and application of cross-linked polystyrene-ethyleneglycol acrylate resin (CLPSER) as a novel polymer support for polypeptide syntheses.	2001 Aug	11532071
Effect of benzoyl peroxide on antioxidant status, NF-kappaB activity and interleukin-1alpha gene expression in human keratinocytes.	2001 Aug 28	11522381
Enzyme-catalyzed decomposition of dibenzoyl peroxide in organic solvents.	2001 Jul-Aug	11531089
The radical-chain addition of aldehydes to alkenes by the use of N-hydroxyphthalimide (NHPI) as a polarity-reversal catalyst.	2001 Nov 21	12240071
[Optimized polymethyl methacrylate-embedding enables exact section examination of the femur with an uncemented femoral stem].	2001 Nov-Dec	11753775
Preparation and comparative clinical evaluation of liposomal gel of benzoyl peroxide for acne.	2001 Sep	11699839
Treatment of rosacea.	2001 Sep	11594676
A clinical and therapeutic study of 29 patients with infantile acne.	2001 Sep	11531837
The modern age of acne therapy: a review of current treatment options.	2001 Sep-Oct	11514915
Clindamycin/benzoyl peroxide gel: a review of its use in the management of acne.	2002	12069641
Influence of polymerization conditions on monomer elution and microhardness of autopolymerized polymethyl methacrylate resin.	2002 Apr	12013564
Consideration on the formulation of benzoyl peroxide at ambient temperature: choice of non-polar solvent and preparation of submicron emulsion gels.	2002 Aug	12236072
Low iron state is associated with reduced tumor promotion in a two-stage mouse skin carcinogenesis model.	2002 Aug	12067571
Improving a self-curing dental resin by eliminating oxygen, hydroquinone and water from its curing process.	2002 Dec	12608426
Studies on MMA-tBB resin. I. Comparison of TBB and other initiators in the polymerization of PMMA/MMA resin.	2002 Dec	12608421
Optimizing the use of tazarotene for the treatment of facial acne vulgaris through combination therapy.	2002 Feb	12095065
The effect of benzoyl peroxide and benzoyl peroxide/erythromycin combination on the antioxidative defence system in papulopustular acne.	2002 Jan-Feb	11809596
Occupational dermatoses among fibreglass-reinforced plastics factory workers.	2002 Jun	12190622
Effect of topical benzoyl peroxide/clindamycin versus topical clindamycin and vehicle in the reduction of Propionibacterium acnes.	2002 Jun	12078851
Oral toxicity of topical preparations.	2002 Mar	12012746
Effect of initiation chemistry on the fracture toughness, fatigue strength, and residual monomer content of a novel high-viscosity, two-solution acrylic bone cement.	2002 Mar 5	11774298
Clindoxyl gel for the treatment of acne vulgaris.	2002 May	12223978
Allergic contact dermatitis from benzoyl peroxide transferred by a loving son.	2002 May	12084087
Starch-based biodegradable hydrogels with potential biomedical applications as drug delivery systems.	2002 May	11996036
The stability of tretinoin in tretinoin gel microsphere 0.1%.	2002 Nov	12469785
Benzoyl peroxide as a cause of airborne contact dermatitis in an orthopaedic technician.	2002 Oct	12492531
Kinetic evaluation of the reactivity of flavonoids as radical scavengers.	2002 Oct	12479376
Clinical evaluation of Double Strength Isotrexin versus Benzamycin in the topical treatment of mild to moderate acne vulgaris.	2002 Sep	12227873
Comparative efficacy of clindamycin and benzoyl peroxide for in vivo suppression of Propionibacterium acnes.	2002 Sep	12227872
Iron augments stage-I and stage-II tumor promotion in murine skin.	2002 Sep 26	12065085
Topical acne drugs: review of clinical properties, systemic exposure, and safety.	2003	12814337
Inhibition of benzoyl peroxide and ultraviolet-B radiation induced oxidative stress and tumor promotion markers by cycloartenol in murine skin.	2003	12804013
Efficacy and safety of stabilised hydrogen peroxide cream (Crystacide) in mild-to-moderate acne vulgaris: a randomised, controlled trial versus benzoyl peroxide gel.	2003	12740158
Guidelines for the management of acne vulgaris in adolescents.	2003	12716217
Organic redox-initiated polymerization process for the fabrication of hydrogels for colon-specific drug delivery.	2003 Apr	12737531
Management of non-neoplastic ovarian cysts with sclerotherapy.	2003 Apr	12676392
Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant.	2003 Feb	12694214
Implications of the BEST study.	2003 Feb	12630673
The BEST study: results according to prior treatment.	2003 Feb	12630672
Improving patient satisfaction and acne severity in patients with mild to moderate acne: the BEST study.	2003 Feb	12630668
Determination of organic peroxides by liquid chromatography with on-line post-column ultraviolet irradiation and peroxyoxalate chemiluminescence detection.	2003 Feb 14	12613811
Management of acne.	2003 Jan	12540312
Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin.	2003 Jan 15	12521598
Progressive iron overload enhances chemically mediated tumor promotion in murine skin.	2003 Jan 15	12504893
Studies on MMA-TBB resin II. The effect of dual use of TBB and other initiators on polymerization of PMMA/MMA resin.	2003 Mar	12790296
Fox-Fordyce disease.	2003 Mar	12705772
Functionalization of carbon nanotubes by free radicals.	2003 May 1	12713301
Improved one-pot synthesis of styryl tetrahydrofurans and cyclohexanes by radical addition to beta-nitrostyrenes in the presence of benzoyl peroxide.	2003 May 9	12740861

Patents

Sample Use Guides

In Vivo Use Guide

Benzamicin gel should be applied twice daily.

Route of Administration: Topical

In Vitro Use Guide

The minimum inhibitory concentrations of Benzoyl peroxide were 128 or 256 ug/mL against all isolates of P. acnes

Substance Class	Chemical Created by `admin` on `Wed Jul 05 22:52:40 UTC 2023` Edited by `admin` on `Wed Jul 05 22:52:40 UTC 2023`
Record UNII	W9WZN9A0GM
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Benzoyl peroxide

Official Name

English

BENZOYL PEROXIDE COMPONENT OF EPIDUO

Common Name

English

BENZAMYCIN COMPONENT BENZOYL PEROXIDE

Common Name

English

Benzoyl peroxide [WHO-DD]

Common Name

English

TWYNEO COMPONENT BENZOYL PEROXIDE

Brand Name

English

BENZOYL PEROXIDE COMPONENT OF ACANYA

Common Name

English

EPIDUO COMPONENT BENZOYL PEROXIDE

Common Name

English

BENZOYL PEROXIDE [IARC]

Common Name

English

PEROXIDE, DIBENZOYL

Systematic Name

English

BENZOYL PEROXIDE [INCI]

Common Name

English

BENZOYL PEROXIDE [USP IMPURITY]

Common Name

English

BENZOYL PEROXIDE [ORANGE BOOK]

Common Name

English

DUAC COMPONENT BENZOYL PEROXIDE

Common Name

English

NSC-675

Code

English

BENZOYL PEROXIDE [MART.]

Common Name

English

BENZOYL PEROXIDE COMPONENT OF DUAC

Common Name

English

ACANYA COMPONENT BENZOYL PEROXIDE

Common Name

English

BENZOYL PEROXIDE [HSDB]

Common Name

English

ANHYDROUS BENZOYL PEROXIDE

Common Name

English

BENZOYL PEROXIDE COMPONENT OF BENZAMYCIN

Common Name

English

INS NO.928

Common Name

English

BENZACLIN COMPONENT BENZOYL PEROXIDE

Common Name

English

NSC-671

Code

English

BENZOYL PEROXIDE ANHYDROUS

Common Name

English

BENZOYL PEROXIDE COMPONENT OF BENZACLIN

Common Name

English

EPSOLAY

Brand Name

English

BENZOYL PEROXIDE [JAN]

Common Name

English

HYDROUS BENZOYL PEROXIDE [WHO-IP]

Common Name

English

BENZOYL PEROXIDE [MI]

Common Name

English

BENZOYL PEROXIDE [USAN]

Common Name

English

IDP-126 component Benzoyl peroxide

Code

English

INS-928

Common Name

English

BENZOYLPEROXIDE

Systematic Name

English

BENZOYL PEROXIDE [VANDF]

Common Name

English

BENZOYL PEROXIDE COMPONENT OF TWYNEO

Brand Name

English

BENZOYL SUPEROXIDE

Common Name

English

HYDROUS BENZOYL PEROXIDE [USP MONOGRAPH]

Common Name

English

BENZOYL PEROXIDE [FCC]

Common Name

English

BENZOYLIS PEROXIDUM CUM AQUA [WHO-IP LATIN]

Common Name

English

DIBENZOYL PEROXIDE

Systematic Name

English

E-928

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

E-928