Benzoyl peroxide

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H10O4
Molecular Weight	242.2268
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

O=C(OOC(=O)C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=OMPJBNCRMGITSC-UHFFFAOYSA-N

InChI=1S/C14H10O4/c15-13(11-7-3-1-4-8-11)17-18-14(16)12-9-5-2-6-10-12/h1-10H

HIDE SMILES / InChI

Molecular Formula	C14H10O4
Molecular Weight	242.2268
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Benzoyl peroxide (BPO) is an organic compound in the peroxide family. It consists of two benzoyl groups bridged by a peroxide link. It is one of the most important organic peroxides in terms of applications and the scale of its production. Benzoyl peroxide is used as an acne treatment, for bleaching hair and teeth. Adverse reactions are: dryness and urticarial reaction, contact dermatitis, application site burning, application site irritation and skin irritation.

Originator

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Acne vulgaris 34	Curative		Approved 8,429	BENZAMYCIN PAK

Doses

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Dose	Population	Adverse events
10 % 2 times / day multiple, topical Highest studied dose	unhealthy, 20 years n = 25	Other AEs: Peeling, Erythema...

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AEs

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AE	Significance	Dose	Population
Erythema	moderate, 30%	10 % 2 times / day multiple, topical Highest studied dose	unhealthy, 20 years n = 25
Peeling	moderate, 55%	10 % 2 times / day multiple, topical Highest studied dose	unhealthy, 20 years n = 25

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
001 Chemical	DY41810	https://www.001chemical.com/chem/94-36-0
3B Scientific (Wuhan) Corp	3B3-034757	http://www.3bsc.com/index/pro_info.php?id=56690
AA Blocks	AA0034FD	https://www.aablocks.com/goods/Goods/detail?id=AA0034FD
AHH Chemical co.,ltd	MT-47566	http://www.ahhchemical.com/product/MT-47566.html
AbMole Bioscience	M3247	http://www.abmole.com/products/benzoyl-peroxide.html

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PubMed

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Title	Date	PubMed
Enhancement of susceptibility to diverse skin tumor promoters by activation of the insulin-like growth factor-1 receptor in the epidermis of transgenic mice.	1999 Jun	10365914
Current issues in antimicrobial therapy for the treatment of acne.	2001	11843235
Comparison of the efficacy and safety of a combination topical gel formulation of benzoyl peroxide and clindamycin with benzoyl peroxide, clindamycin and vehicle gel in the treatments of acne vulgaris.	2001	11702619
Interleukin-6 expression by osteoblast-like MG63 cells challenged with four acrylic bone cements.	2001	11403239
Lupeol, a triterpene, inhibits early responses of tumor promotion induced by benzoyl peroxide in murine skin.	2001 Feb	11243713