Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C11H15N5O3 |
| Molecular Weight | 265.2685 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C2N=CN([C@H]3CC[C@@H](CO)O3)C2=NC(N)=N1
InChI
InChIKey=FJAOCNGVPLTSLD-NKWVEPMBSA-N
InChI=1S/C11H15N5O3/c1-18-10-8-9(14-11(12)15-10)16(5-13-8)7-3-2-6(4-17)19-7/h5-7,17H,2-4H2,1H3,(H2,12,14,15)/t6-,7+/m0/s1
| Molecular Formula | C11H15N5O3 |
| Molecular Weight | 265.2685 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:46:13 UTC 2023
by
admin
on
Sat Dec 16 11:46:13 UTC 2023
|
| Record UNII |
W5EOS3V193
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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10355487
Created by
admin on Sat Dec 16 11:46:13 UTC 2023 , Edited by admin on Sat Dec 16 11:46:13 UTC 2023
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PRIMARY | |||
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120503-45-9
Created by
admin on Sat Dec 16 11:46:13 UTC 2023 , Edited by admin on Sat Dec 16 11:46:13 UTC 2023
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PRIMARY | |||
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W5EOS3V193
Created by
admin on Sat Dec 16 11:46:13 UTC 2023 , Edited by admin on Sat Dec 16 11:46:13 UTC 2023
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PRIMARY |
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ACTIVE MOIETY |
Metacavir (PNA) is a novel synthetic nucleoside analog for oral administration with potent and specific antiviral activity against hepatitis B virus (HBV). We assessed the potential for mitochondrial toxicity of PNA in long-term cultures of HepG2 hepatoma cells by measuring mitochondrial function (through lactate secretion), levels of mitochondrial DNA (mtDNA), and the activities of respiratory-chain complexes I to IV. Exposure of HepG2 cells to PNA at concentrations up to 50 .MU.M for 15 days resulted in no deleterious effect on cell proliferation, levels of lactate or mtDNA, or enzyme activities of respiratory-chain complexes I to IV. In contrast, dideoxycytosine at 10 .MU.M and zidovudine at 50 .MU.M have significant effects on cell proliferation, levels of lactate and mtDNA, and enzyme activities of respiratory-chain complexes I to IV.
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