DEXLOFEXIDINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H12Cl2N2O
Molecular Weight	259.132
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H](OC1=C(Cl)C=CC=C1Cl)C2=NCCN2

InChI

InChIKey=KSMAGQUYOIHWFS-ZETCQYMHSA-N

InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)/t7-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C11H12Cl2N2O
Molecular Weight	259.132
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2879913

Dexlofexidine is an isomer “+“ of lofexidine, which is agonist of alpha 2-adrenoceptor, but in 10 times less potent than the other isomer, levlofexidine.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha-2 114 Target ID: CHEMBL2095158 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2879913	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Pharmacokinetics of lofexidine hydrochloride in healthy volunteers.	2009-01	18393298
Two stereoisomeric imidazoline derivatives: synthesis and optical and alpha 2-adrenoceptor activities.	1986-07	2879913
Interference of enantiomers of lofexidine with alpha-adrenoceptors.	1985-01	2988468

Patents

Sample Use Guides

In Vivo Use Guide

in rats

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:19:54 GMT 2025` Edited by `admin` on `Mon Mar 31 18:19:54 GMT 2025`
Record UNII	VXJ7Z24RN1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEXLOFEXIDINE

Official Name

English

LOFEXIDINE, (S)-

Preferred Name

English

(+)-(S)-2-(1-(2,6-DICHLOROPHENOXY)ETHYL)-2-IMIDAZOLINE

Systematic Name

English

dexlofexidine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29709