DEXLOFEXIDINE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H12Cl2N2O.ClH
Molecular Weight	295.593
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DEXLOFEXIDINE HYDROCHLORIDE

Structure Search

SMILES

Cl.C[C@H](OC1=C(Cl)C=CC=C1Cl)C2=NCCN2

InChI

InChIKey=DWWHMKBNNNZGHF-FJXQXJEOSA-N

InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H/t7-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C11H12Cl2N2O
Molecular Weight	259.132
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2879913

Dexlofexidine is an isomer “+“ of lofexidine, which is agonist of alpha 2-adrenoceptor, but in 10 times less potent than the other isomer, levlofexidine.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha-2 114 Target ID: CHEMBL2095158 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2879913	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Pharmacokinetics of lofexidine hydrochloride in healthy volunteers.	2009-01	18393298
Two stereoisomeric imidazoline derivatives: synthesis and optical and alpha 2-adrenoceptor activities.	1986-07	2879913
Interference of enantiomers of lofexidine with alpha-adrenoceptors.	1985-01	2988468

Patents

Sample Use Guides

In Vivo Use Guide

in rats

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:41:19 GMT 2025` Edited by `admin` on `Mon Mar 31 23:41:19 GMT 2025`
Record UNII	56H4BIV8OG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEXLOFEXIDINE HYDROCHLORIDE

Common Name

English

1H-IMIDAZOLE, 2-(1-(2,6-DICHLOROPHENOXY)ETHYL)-4,5-DIHYDRO-, MONOHYDROCHLORIDE, (S)-

Preferred Name

English

1H-IMIDAZOLE, 2-((1S)-1-(2,6-DICHLOROPHENOXY)ETHYL)-4,5-DIHYDRO-, HYDROCHLORIDE (1:1)

Systematic Name

English

LOFEXIDINE HYDROCHLORIDE, (+)-

Common Name

English

LOFEXIDINE HYDROCHLORIDE, (S)-

Common Name

English

Code System Code Type Description

PUBCHEM

45279768

Created by admin on Mon Mar 31 23:41:19 GMT 2025 , Edited by admin on Mon Mar 31 23:41:19 GMT 2025

PRIMARY

FDA UNII

56H4BIV8OG

Created by admin on Mon Mar 31 23:41:19 GMT 2025 , Edited by admin on Mon Mar 31 23:41:19 GMT 2025

PRIMARY

CAS

87858-98-8

Created by admin on Mon Mar 31 23:41:19 GMT 2025 , Edited by admin on Mon Mar 31 23:41:19 GMT 2025

PRIMARY

Related Record Type Details


					V47G1SDI1B

LOFEXIDINE HYDROCHLORIDE

RACEMATE -> ENANTIOMER


					VXJ7Z24RN1

DEXLOFEXIDINE

PARENT -> SALT/SOLVATE

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/2879913

Approval Year

Targets

Conditions

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2879913