THIACETARSAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H12AsNO5S2
Molecular Weight	377.268
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C1=CC=C(C=C1)[As](SCC(O)=O)SCC(O)=O

InChI

InChIKey=YBQWEUNEYYXYOI-UHFFFAOYSA-N

InChI=1S/C11H12AsNO5S2/c13-11(18)7-1-3-8(4-2-7)12(19-5-9(14)15)20-6-10(16)17/h1-4H,5-6H2,(H2,13,18)(H,14,15)(H,16,17)

HIDE SMILES / InChI

Molecular Formula	C11H12AsNO5S2
Molecular Weight	377.268
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://hal.archives-ouvertes.fr/hal-00902045/document | https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1751-0813.1974.tb02365.x

Thiacetarsamide is a drug containing trivalent arsenic. In the USA it was used for the treatment of Heartworm Infection in dogs and cats under tradename Caparsolate, however, it was discontinued because of the availability of safer alternatives. The mechanism of action for thiacetarsamide is modulation of glucose uptake and metabolism; inhibition of glutathione reductase, and alteration of the structure and function of the surface of the intestinal epithelium of the parasites.

Approval Year

PubMed

Title	Date	PubMed
Thioarsenites in amebiasis; a clinical appraisal of new amebacides.	1949-08-20	18137275
Parasiticidal activity of thioarsenites in man.	1948-03	18938296

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:07:57 GMT 2025` Edited by `admin` on `Mon Mar 31 18:07:57 GMT 2025`
Record UNII	VMF4ELY9TZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIACETARSAMIDE

Common Name

English

(((P-CARBAMOYLPHENYL)ARSYLENE)DITHIO)DIACETIC ACID

Preferred Name

English

THIOARSENITE

Systematic Name

English

DITHIOGLYCOLYL P-ARSENOBENZAMIDE

Common Name

English

P-(BIS(CARBOXYMETHYLMERCAPTO)ARSINO)BENZAMIDE

Common Name

English

4-CARBAMYLPHENYL BIS(CARBOXYMETHYLTHIO)ARSENITE

Systematic Name

English

2,2'-(((4-(AMINOCARBONYL)PHENYL)ARSINIDENE)BIS(THIO))BISACETIC ACID

Systematic Name

English

ARSENAMIDE

Common Name

English

THIACETARSAMIDE [MI]

Common Name

English

BIS(CARBOXYMETHYLMERCAPTO)(P-CARBAMYLPHENYL)-ARSINE

Common Name

English

4-Carbamylphenyl biscarboxymethylthioarsenite

Systematic Name

English

BENZAMIDE, P-BIS(CARBOXYMETHYLMERCAPTO)ARSINO

Common Name

English

THIACETARSAMIDE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250