THIACETARSAMIDE SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H10AsNO5S2.2Na
Molecular Weight	421.232
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].NC(=O)C1=CC=C(C=C1)[As](SCC([O-])=O)SCC([O-])=O

InChI

InChIKey=AXRWJSAOLNNBNI-UHFFFAOYSA-L

InChI=1S/C11H12AsNO5S2.2Na/c13-11(18)7-1-3-8(4-2-7)12(19-5-9(14)15)20-6-10(16)17;;/h1-4H,5-6H2,(H2,13,18)(H,14,15)(H,16,17);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C11H10AsNO5S2
Molecular Weight	375.252
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://hal.archives-ouvertes.fr/hal-00902045/document | https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1751-0813.1974.tb02365.x

Thiacetarsamide is a drug containing trivalent arsenic. In the USA it was used for the treatment of Heartworm Infection in dogs and cats under tradename Caparsolate, however, it was discontinued because of the availability of safer alternatives. The mechanism of action for thiacetarsamide is modulation of glucose uptake and metabolism; inhibition of glutathione reductase, and alteration of the structure and function of the surface of the intestinal epithelium of the parasites.

Approval Year

PubMed

Title	Date	PubMed
Parasiticidal activity of thioarsenites in man.	1948 Mar	18938296
Thioarsenites in amebiasis; a clinical appraisal of new amebacides.	1949 Aug 20	18137275

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:24:14 GMT 2023` Edited by `admin` on `Fri Dec 15 16:24:14 GMT 2023`
Record UNII	KW75J7708X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIACETARSAMIDE SODIUM

Official Name

English

ARSENAMIDE SODIUM [GREEN BOOK]

Common Name

English

SODIUM ARSENAMIDE

Common Name

English

thiacetarsamide sodium [INN]

Common Name

English

ARSENAMIDE SODIUM

Common Name

English

THIACETARSAMIDE DISODIUM SALT [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250