U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H26O5
Molecular Weight 358.4281
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PREDNISONE

SMILES

[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=XOFYZVNMUHMLCC-ZPOLXVRWSA-N
InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula C21H26O5
Molecular Weight 358.4281
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including

Prednisone is a synthetic anti-inflammatory glucocorticoid derived from cortisone. Prednisone is a corticosteroid indicated as an anti-inflammatory or immunosuppressive agent allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, specific infectious diseases or conditions and organ transplantation; for the treatment of certain endocrine conditions; for palliation of certain neoplastic conditions. The pharmacological effects of prednisone which are due to its corticosteroid properties include: promotion of gluconeogenesis; increased deposition of glycogen in the liver; inhibition of the utilization of glucose; anti-insulin activity; increased catabolism of protein; increased lipolysis; stimulation of fat synthesis and storage; increased glomerular filtration rate and resulting increase in urinary excretion of urate (creatinine excretion remains unchanged); and increased calcium excretion. Depressed production of eosinophils and lymphocytes occurs, but erythropoiesis and production of polymorphonuclear leukocytes are stimulated. Inflammatory processes (edema, fibrin deposition, capillary dilatation, migration of leukocytes and phagocytosis) and the later stages of wound healing (capillary proliferation, deposition of collagen, cicatrization) are inhibited. Prednisone can stimulate secretion of various components of gastric juice. Suppression of the production of corticotropin may lead to suppression of endogenous corticosteroids. Prednisone has slight mineralocorticoid activity, whereby entry of sodium into cells and loss of intracellular potassium is stimulated. This is particularly evident in the kidney, where rapid ion exchange leads to sodium retention and hypertension. Prednisone is completely converted to the active metabolite prednisolone, which is further metabolized mainly in the liver and excreted in the urine as sulfate and glucuronide conjugates. The exposure of prednisolone is 4-6 fold higher than that of prednisone.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
RAYOS

Approved Use

RAYOS is a corticosteroid indicated as an anti-inflammatory or immunosuppressive agent for certain allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, specific infectious diseases or conditions and organ transplantation; for the treatment of certain endocrine conditions; for palliation of certain neoplastic conditions

Launch Date

2012
Palliative
RAYOS

Approved Use

RAYOS is a corticosteroid indicated as an anti-inflammatory or immunosuppressive agent for certain allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, specific infectious diseases or conditions and organ transplantation; for the treatment of certain endocrine conditions; for palliation of certain neoplastic conditions

Launch Date

2012
Palliative
RAYOS

Approved Use

RAYOS is a corticosteroid indicated as an anti-inflammatory or immunosuppressive agent for certain allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, specific infectious diseases or conditions and organ transplantation; for the treatment of certain endocrine conditions; for palliation of certain neoplastic conditions

Launch Date

2012
Palliative
RAYOS

Approved Use

RAYOS is a corticosteroid indicated as an anti-inflammatory or immunosuppressive agent for certain allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, specific infectious diseases or conditions and organ transplantation; for the treatment of certain endocrine conditions; for palliation of certain neoplastic conditions

Launch Date

2012
Palliative
RAYOS

Approved Use

RAYOS is a corticosteroid indicated as an anti-inflammatory or immunosuppressive agent for certain allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, specific infectious diseases or conditions and organ transplantation; for the treatment of certain endocrine conditions; for palliation of certain neoplastic conditions

Launch Date

2012
Palliative
RAYOS

Approved Use

RAYOS is a corticosteroid indicated as an anti-inflammatory or immunosuppressive agent for certain allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, specific infectious diseases or conditions and organ transplantation; for the treatment of certain endocrine conditions; for palliation of certain neoplastic conditions

Launch Date

2012
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
15.4 μg/L
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PREDNISONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
97 μg × h/L
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PREDNISONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
3.85 h
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PREDNISONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
50%
PREDNISONE plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
100 mg 1 times / day multiple, oral
Highest studied dose
Dose: 100 mg, 1 times / day
Route: oral
Route: multiple
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adult
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources: Page: p. 92
unhealthy, adult
n = 144
Health Status: unhealthy
Age Group: adult
Population Size: 144
Sources: Page: p. 92
Disc. AE: Vertigo, Abdominal pain upper...
AEs leading to
discontinuation/dose reduction:
Vertigo (1%)
Abdominal pain upper (1%)
Gastroesophageal reflux disease (1%)
Intestinal functional disorder (1%)
Nausea (1%)
Dizziness (1%)
Aphasia (1%)
Headache (1%)
Renal pain (1%)
Sources: Page: p. 92
AEs

AEs

AESignificanceDosePopulation
Abdominal pain upper 1%
Disc. AE
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources: Page: p. 92
unhealthy, adult
n = 144
Health Status: unhealthy
Age Group: adult
Population Size: 144
Sources: Page: p. 92
Aphasia 1%
Disc. AE
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources: Page: p. 92
unhealthy, adult
n = 144
Health Status: unhealthy
Age Group: adult
Population Size: 144
Sources: Page: p. 92
Dizziness 1%
Disc. AE
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources: Page: p. 92
unhealthy, adult
n = 144
Health Status: unhealthy
Age Group: adult
Population Size: 144
Sources: Page: p. 92
Gastroesophageal reflux disease 1%
Disc. AE
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources: Page: p. 92
unhealthy, adult
n = 144
Health Status: unhealthy
Age Group: adult
Population Size: 144
Sources: Page: p. 92
Headache 1%
Disc. AE
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources: Page: p. 92
unhealthy, adult
n = 144
Health Status: unhealthy
Age Group: adult
Population Size: 144
Sources: Page: p. 92
Intestinal functional disorder 1%
Disc. AE
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources: Page: p. 92
unhealthy, adult
n = 144
Health Status: unhealthy
Age Group: adult
Population Size: 144
Sources: Page: p. 92
Nausea 1%
Disc. AE
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources: Page: p. 92
unhealthy, adult
n = 144
Health Status: unhealthy
Age Group: adult
Population Size: 144
Sources: Page: p. 92
Renal pain 1%
Disc. AE
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources: Page: p. 92
unhealthy, adult
n = 144
Health Status: unhealthy
Age Group: adult
Population Size: 144
Sources: Page: p. 92
Vertigo 1%
Disc. AE
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources: Page: p. 92
unhealthy, adult
n = 144
Health Status: unhealthy
Age Group: adult
Population Size: 144
Sources: Page: p. 92
PubMed

PubMed

TitleDatePubMed
Cytogenetic studies in a patient with acute granulocytic leukemia of seven and one-half years duration.
1975 Nov
An unusual adverse reaction to self-medication with prednisone: an irrational crime during a fugue-state.
1976-1977
Spontaneous aortic rupture associated with chronic steroid therapy for rheumatoid arthritis in two cases.
1979 Feb
Low-dose vincristine-associated bilateral vocal cord paralysis.
1999 Oct
Lamotrigine as prophylaxis against steroid-induced mania.
1999 Oct
Delayed generalized allergic reactions to corticosteroids.
2000
Acute neurotoxicity in children with B-lineage acute lymphoblastic leukemia (B-ALL) treated with intermediate risk protocols.
2000 Nov
Leucocytoclastic vasculitis and indinavir.
2000 Nov
Pulmonary mucosa-associated lymphoid tissue lymphoma in a patient with common variable immunodeficiency syndrome.
2001
Cyclophosphamide and antithymocyte globulin to condition patients with aplastic anemia for allogeneic marrow transplantations: the experience in four centers.
2001
Hodgkin's disease: clinical presentation and treatment.
2001
Current status of cytotoxic chemotherapy in hormone refractory prostate cancer.
2001 Feb
The usefulness of quantitative orbital magnetic resonance imaging in Graves' ophthalmopathy.
2001 Feb
Interstitial nephritis in patients with inflammatory bowel disease treated with mesalamine.
2001 Feb
Recalcitrant allergic contact dermatitis from azathioprine tablets.
2001 Feb
Idiopathic IgA nephropathy with segmental necrotizing lesions of the capillary wall.
2001 Feb
Interferon alfa 2b as maintenance therapy in poor risk diffuse large B-cell lymphoma in complete remission after intensive CHOP-BLEO regimens.
2001 Feb
Time course of 21-hydroxylase antibodies and long-term remission of subclinical autoimmune adrenalitis after corticosteroid therapy: case report.
2001 Feb
Adult Gaucher disease in association with primary malignant bone tumors.
2001 Feb 1
Long-term results of combined-modality therapy for locally advanced breast cancer with ipsilateral supraclavicular metastases: The University of Texas M.D. Anderson Cancer Center experience.
2001 Feb 1
Sample size calculations for the two-sample problem using the multiplicative intensity model.
2001 Feb 28
Two-year effects of alendronate on bone mineral density and vertebral fracture in patients receiving glucocorticoids: a randomized, double-blind, placebo-controlled extension trial.
2001 Jan
Nocardia pleural empyema complicating anti-Jo1 positive polymyositis during immunoglobulin and steroid therapy.
2001 Jan
Plasmapheresis as an effective treatment for opsoclonus-myoclonus syndrome.
2001 Jan
Longitudinal assessment of everolimus in de novo renal transplant recipients over the first post-transplant year: pharmacokinetics, exposure-response relationships, and influence on cyclosporine.
2001 Jan
Persistent paraneoplastic neurologic syndrome after successful therapy of Hodgkin's disease.
2001 Jan
A high serum-soluble interleukin-2 receptor level is associated with a poor outcome of aggressive non-Hodgkin's lymphoma.
2001 Jan
Multiple myeloma in elderly patients: presenting features and outcome.
2001 Jan
Immunosuppression as adjuvant therapy for biliary atresia.
2001 Jan
Biliary stricture secondary to donor B-cell lymphoma after orthotopic liver transplantation.
2001 Jan
Efficacy of parenteral methotrexate in refractory Crohn's disease.
2001 Jan
Diabetes insipidus and anterior pituitary insufficiency as presenting features of Wegener's granulomatosis.
2001 Jan
Cause of high variability in drug dissolution testing and its impact on setting tolerances.
2001 Jan
Dose-response analysis for radiotherapy delivered to patients with intermediate-grade and large-cell immunoblastic lymphomas that have completely responded to CHOP-based induction chemotherapy.
2001 Jan 1
Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: a phase III study of the European organization for research and treatment of cancer genitourinary group.
2001 Jan 1
High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial.
2001 Jan 15
Combined treatment of giant-cell arteritis with methotrexate and prednisone. a randomized, double-blind, placebo-controlled trial.
2001 Jan 16
Ethnic differences in clinical response to corticosteroid treatment of acute renal allograft rejection.
2001 Jan 27
Autologous bone marrow transplantation for aggressive non-Hodgkin's lymphoma: lessons learned and challenges remaining.
2001 Jan 3
Use of biological markers of airway inflammation to detect the efficacy of nurse-delivered asthma education.
2001 Jan-Feb
Depression or hypoactive delirium? A report of ciprofloxacin-induced mental disorder in a patient with chronic obstructive pulmonary disease.
2001 Jan-Feb
Patents

Sample Use Guides

The initial dosage of RAYOS (prednisone) may vary from 5 to 60 mg per day depending on the specific disease entity being treated based on relative potency.
Route of Administration: Oral
In Vitro Use Guide
Peripheral blood lymphocytes (PBL) or peripheral CD4(+) and CD8(+) T cell subsets were cultured in the presence of prednisone (PDN) at 10(-3)-10(-12)M concentrations for 72, 96 and 120h. Apoptosis is clearly increased by PDN and the apoptotic effect of PDN is stronger on CD8(+) than on CD4(+) T lymphocytes.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:51:36 GMT 2023
Edited
by admin
on Fri Dec 15 15:51:36 GMT 2023
Record UNII
VB0R961HZT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PREDNISONE
EP   HSDB   INN   MART.   MI   ORANGE BOOK   VANDF   WHO-DD  
INN  
Official Name English
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
Systematic Name English
PREGNA-1,4-DIENE-3,11,20-TRIONE, 17,21-DIHYDROXY-
Systematic Name English
PREDNISONE TABLETS [USP-RS]
Common Name English
PREDNISONE INTENSOL
Brand Name English
Prednisone [WHO-DD]
Common Name English
SUPERCORTIL
Common Name English
METACORTANDRACIN
Common Name English
PREDNISONE [USP MONOGRAPH]
Common Name English
PREDNISONE ANHYDROUS
Common Name English
3EN3HG4WSW
Common Name English
PREDNISONE [GREEN BOOK]
Common Name English
NSC-10023
Code English
prednisone [INN]
Common Name English
DELTASONE
Brand Name English
DEHYDROCORTISONE
Common Name English
PREDNISONE [USP-RS]
Common Name English
PREDNISONE [ORANGE BOOK]
Common Name English
PREDNISONE [EP MONOGRAPH]
Common Name English
PREDNISONE TABLETS
USP-RS  
Common Name English
PREDNISONE [IARC]
Common Name English
PREDNISONE [VANDF]
Common Name English
PREDNISONE [HSDB]
Common Name English
PREDNISONE [MART.]
Common Name English
PREDNISONE [MI]
Common Name English
DECORTIN
Brand Name English
PREDNISOLONE IMPURITY B [EP IMPURITY]
Common Name English
Classification Tree Code System Code
WHO-ATC H02AB07
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
WHO-ATC A07EA03
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
WHO-VATC QH02AB07
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
NCI_THESAURUS C521
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
IARC Prednisone
WHO-VATC QH02AB57
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
CFR 21 CFR 522.1890
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
LIVERTOX 795
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
NDF-RT N0000175450
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
WHO-VATC QA07EA03
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
NDF-RT N0000175576
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C770
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
RXCUI
8640
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY RxNorm
HSDB
3168
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
MERCK INDEX
m9112
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY Merck Index
RS_ITEM_NUM
1559006
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
FDA UNII
VB0R961HZT
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
CHEBI
8382
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
INN
536
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PRIMARY
DRUG BANK
DB00635
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
DRUG CENTRAL
2253
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-160-3
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
IUPHAR
7096
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
EVMPD
SUB10020MIG
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
DAILYMED
VB0R961HZT
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
RS_ITEM_NUM
1559505
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
ALTERNATIVE
SMS_ID
100000091943
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
PUBCHEM
5865
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
MESH
D011241
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
EPA CompTox
DTXSID4021185
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
LACTMED
Prednisone
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
ChEMBL
CHEMBL635
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
NSC
10023
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
CAS
53-03-2
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
WIKIPEDIA
PREDNISONE
Created by admin on Fri Dec 15 15:51:36 GMT 2023 , Edited by admin on Fri Dec 15 15:51:36 GMT 2023
PRIMARY
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Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
MAXIMUM TOLERATED DOSE TOXICITY
Volume of Distribution PHARMACOKINETIC
Tmax PHARMACOKINETIC PREDNISOLONE (ACTIVE METABOLITE), ORAL
PHARMACOKINETIC
DELAYED-RELEASE, ORAL
PHARMACOKINETIC
ORAL BIOAVAILABILITY PHARMACOKINETIC