Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H21NO2 |
| Molecular Weight | 282.3656 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@](OC1=C([11CH3])C=CC=C1)(C2=CC=CC=C2)[C@]3([H])CNCCO3
InChI
InChIKey=BTDIKAPSRZPGSC-RIVWMEAKSA-N
InChI=1S/C18H21NO2/c1-14-7-5-6-10-16(14)21-18(15-8-3-2-4-9-15)17-13-19-11-12-20-17/h2-10,17-19H,11-13H2,1H3/t17-,18-/m0/s1/i1-1
| Molecular Formula | C18H21NO2 |
| Molecular Weight | 282.3656 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:36:22 UTC 2023
by
admin
on
Sat Dec 16 10:36:22 UTC 2023
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| Record UNII |
VA46LC5AZQ
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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1097104-30-7
Created by
admin on Sat Dec 16 10:36:22 UTC 2023 , Edited by admin on Sat Dec 16 10:36:22 UTC 2023
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25188768
Created by
admin on Sat Dec 16 10:36:22 UTC 2023 , Edited by admin on Sat Dec 16 10:36:22 UTC 2023
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PRIMARY | |||
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VA46LC5AZQ
Created by
admin on Sat Dec 16 10:36:22 UTC 2023 , Edited by admin on Sat Dec 16 10:36:22 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
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TARGET->RADIOLIGAND |
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NON-LABELED -> LABELED |
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
((11)C)MENET, a promising norepinephrine transporter imaging agent, was prepared by Suzuki cross coupling of 1mg N-t-Boc pinacolborate precursor with ((11)C)CH3 I in DMF using palladium complex generated in situ from Pd2 (dba)3 and (o-CH3 C6 H4 )3 P together with K2 CO3 as the co-catalyst, followed by deprotection with trifluoroacetic acid. This improved radiolabeling method provided ((11)C)MENET in high radiochemical yield at end of synthesis (EOS, 51+/-3%, decay-corrected from end of (11) CH3 I synthesis, n=6), moderate specific activity (1.5-1.9Ci/undefinedmol at EOS), and high radiochemical (>98%) and chemical purity (>98%) in a synthesis time of 60+/-5min from the end of bombardment.
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