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Details

Stereochemistry ACHIRAL
Molecular Formula C4H4O4.2Na
Molecular Weight 162.0517
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM SUCCINATE ANHYDROUS

SMILES

[Na+].[Na+].[O-]C(=O)CCC([O-])=O

InChI

InChIKey=ZDQYSKICYIVCPN-UHFFFAOYSA-L
InChI=1S/C4H6O4.2Na/c5-3(6)1-2-4(7)8;;/h1-2H2,(H,5,6)(H,7,8);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/23461009 | https://www.ncbi.nlm.nih.gov/pubmed/24771373 | https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=PB254541 | https://www.ncbi.nlm.nih.gov/pubmed/10464017

Succinic acid is a dicarboxylic acid, which has multiple biological roles as a metabolic intermediate being converted into fumarate by the enzyme succinate dehydrogenase in complex 2 of the electron transport chain which is involved in making ATP, and as a signaling molecule reflecting the cellular metabolic state. Succinate is generated in mitochondria via the tricarboxylic acid cycle (TCA), an energy-yielding process shared by all organisms. Succinate can exit the mitochondrial matrix and function in the cytoplasm as well as the extracellular space, changing gene expression patterns, modulating epigenetic landscape or demonstrating hormone-like signaling. Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leigh's disease, and Mela's disease and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury. Succinic acid is a precursor to some polyesters and a component of some alkyd resins. Succinic acid also serves as the bases of certain biodegradable polymers, which are of interest in tissue engineering applications. As a food additive and dietary supplement, succinic acid is generally recognized as safe by the U.S. Food and Drug Administration. Succinic acid is used primarily as an acidity regulator in the food and beverage industry. It is also available as a flavoring agent, contributing a somewhat sour and astringent component to umami taste.[11] As an excipient in pharmaceutical products, it is also used to control acidity or as a counter ion. Drugs involving succinate include metoprolol succinate, sumatriptan succinate, Doxylamine succinate or solifenacin succinate.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
3.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Reamberin

Approved Use

Unknown
Inactive ingredient
Metoprolol Succinate ER

Approved Use

Unknown
Inactive ingredient
VESIcare

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Oxidative and glycolytic metabolism of semen components by washed guinea pig spermatozoa.
1975 Feb
Structures and proton-pumping strategies of mitochondrial respiratory enzymes.
2001
Inhibition of spontaneous induction of lambdoid prophages in Escherichia coli cultures: simple procedures with possible biotechnological applications.
2001
[Intermittent hypoxic training with exogenous nitric oxide improves rat liver mitochondrial oxidation and phosphorylation during acute hypoxia].
2001
[Combined treatment of purulent-necrotic lesions of lower extremities in diabetic patients].
2001
Tetracycline residues in meat and bone meals. Part 1: methodology and examination of field samples.
2001 Apr
Synthesis of ethyl alkylidene alpha cyanoacetates under ultrasound irradiation.
2001 Apr
Rat liver microsomal lipid peroxidation produced during the oxidative metabolism of ethacrynic acid.
2001 Apr
Inhibition of Escherichia coli respiratory enzymes by the lactoperoxidase-hydrogen peroxide-thiocyanate antimicrobial system.
2001 Apr
A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons.
2001 Apr
Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate.
2001 Apr
Combined effect of propofol and GSNO on oxidative phosphorylation of isolated rat liver mitochondria.
2001 Apr
Identification of respiratory complexes I and III as mitochondrial sites of damage following exposure to ionizing radiation and nitric oxide.
2001 Apr
The effects of feed and intracellular pyruvate levels on the redistribution of metabolic fluxes in Escherichia coli.
2001 Apr
Glutamine supplementation promotes anaplerosis but not oxidative energy delivery in human skeletal muscle.
2001 Apr
Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.
2001 Apr 1
Germline SDHD mutation in familial phaeochromocytoma.
2001 Apr 14
New insights into the regulation of plant succinate dehydrogenase. On the role of the protonmotive force.
2001 Aug 31
A subtoxic interactive toxicity study of ethanol and chromium in male Wistar rats.
2001 Feb
A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region.
2001 Feb
Effects of cresols (o-, m-, and p-isomers) on the bioenergetic system in isolated rat liver mitochondria.
2001 Feb
Exercise and ovarian steroid hormones: their effects on mitochondrial respiration.
2001 Feb 16
Paradoxical effects of copper and manganese on brain mitochondrial function.
2001 Feb 23
Dimeric pig heart succinate-coenzyme A transferase uses only one subunit to support catalysis.
2001 Feb 27
Time-course changes in arteriolar and venular portions of capillary in young treadmill-trained rats.
2001 Jan
Developmental aspects of the rat endolymphatic sac and functional implications.
2001 Jan
[High cell density culture of phosphotransacetylase mutants of Escherichia coli BL21(DE3)].
2001 Jan
Changes in various measures of immune status in mice subject to chronic social conflict.
2001 Jan-Feb
Alloxan-induced mitochondrial permeability transition triggered by calcium, thiol oxidation, and matrix ATP.
2001 Jul 20
Simultaneous chromium(VI) reduction and phenol degradation in a fixed-film coculture bioreactor: reactor performance.
2001 Jun
Retention of heme in axial ligand mutants of succinate-ubiquinone xxidoreductase (complex II) from Escherichia coli.
2001 Jun 1
Tissue reactions to epoxy-crosslinked porcine heart valves post-treated with detergents or a dicarboxylic acid.
2001 Jun 5
Kinetic analyses of mitochondrial 75selenium uptake in Trigonella foenum-graecum seedlings exposed to selenium and mimosine.
2001 Mar
Metabolic enzymes and phenotypic expression among human locomotor muscles.
2001 Mar
A general method for the quantitative analysis of functional chimeras: applications from site-directed mutagenesis and macromolecular association.
2001 Mar
Oligoacetic acid characterization by isocratic and linear salt gradient anion-exchange chromatography.
2001 Mar
A third crystal form of Wolinella succinogenes quinol:fumarate reductase reveals domain closure at the site of fumarate reduction.
2001 Mar
Depletion of glutathione up-regulates mitochondrial complex I expression in glial cells.
2001 Mar
Barth's syndrome-like disorder: a new phenotype with a maternally inherited A3243G substitution of mitochondrial DNA (MELAS mutation).
2001 Mar 1
The simplest supramolecular complexes containing pairs of Mo(2)(formamidinate)(3) units linked with various dicarboxylates: preparative methods, structures, and electrochemistry.
2001 Mar 12
Analysis of sulfonated compounds by ion-exchange high-performance liquid chromatography-mass spectrometry.
2001 Mar 30
Effects of culture conditions on enhancement of 2,4-dinitrotoluene degradation by Burkholderia engineered with the Vitreoscilla hemoglobin gene.
2001 Mar-Apr
Possible involvement of protein phosphorylation in aluminum-responsive malate efflux from wheat root apex.
2001 May
Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells.
2001 May
Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS).
2001 May 18
The Quinone-binding sites of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase.
2001 May 18
J-domain protein, Jac1p, of yeast mitochondria required for iron homeostasis and activity of Fe-S cluster proteins.
2001 May 18
The 'strict' anaerobe Desulfovibrio gigas contains a membrane-bound oxygen-reducing respiratory chain.
2001 May 4
In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation.
2001 May 4
Aerobic capacity of frog skeletal muscle during hibernation.
2001 May-Jun
Patents

Sample Use Guides

Human: 0.20mh/kg/day up tp 12.2mg
Route of Administration: Oral
Antiviral activity was measured in a plaque inhibition assay. Confluent Vero cell monolayer in 6-well multidishes were infected with 100 PFU in 1 mL of MEM medium. After adsorption at 37 °C for 2 h, residual inoculum was replaced with 1 mL of MEM medium containing 0.2% gamma-globulin and 1 mL of a dilution of varying concentrations of the Succinic acid. Virus-infected wells without compounds were used as cytopathogenicity controls. Viral cytopathogenicity (CPE) was completed 1-2 days after viral infection
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:32:40 UTC 2023
Edited
by admin
on Wed Jul 05 23:32:40 UTC 2023
Record UNII
V8ZGC8ISR3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM SUCCINATE ANHYDROUS
Common Name English
FEMA NO. 3277
Code English
DISODIUM SUCCINATE [INCI]
Common Name English
SODIUM SUCCINATE [MART.]
Common Name English
DISODIUM BUTANEDIOATE
Systematic Name English
SODIUM SUCCINATE [MI]
Common Name English
ANHYDROUS SODIUM SUCCINATE [USP-RS]
Common Name English
SODIUM SUCCINATE, ANHYDROUS
Common Name English
SUCCINATE SODIUM
WHO-DD  
Systematic Name English
DISODIUM SUCCINATE
FHFI   INCI  
INCI  
Official Name English
Succinate sodium [WHO-DD]
Common Name English
BUTANEDIOIC ACID DISODIUM SALT
Common Name English
DISODIUM SUCCINATE [FHFI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C345
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
Code System Code Type Description
SMS_ID
100000085549
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
ECHA (EC/EINECS)
237-884-4
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
ALTERNATIVE
RS_ITEM_NUM
1614716
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
FDA UNII
V8ZGC8ISR3
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
CAS
14047-56-4
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
NON-SPECIFIC STOICHIOMETRY
EVMPD
SUB12593MIG
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
EVMPD
SUB20439
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
DAILYMED
V8ZGC8ISR3
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
MERCK INDEX
M10078
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY Merck Index
RXCUI
1307107
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY RxNorm
PUBCHEM
9020
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
ECHA (EC/EINECS)
205-778-7
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
CAS
150-90-3
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
CHEBI
63675
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
EPA CompTox
DTXSID5059741
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
NCI_THESAURUS
C84169
Created by admin on Wed Jul 05 23:32:40 UTC 2023 , Edited by admin on Wed Jul 05 23:32:40 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY