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Details

Stereochemistry ACHIRAL
Molecular Formula C4H4O4.2Na
Molecular Weight 162.0517
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM SUCCINATE ANHYDROUS

SMILES

[Na+].[Na+].[O-]C(=O)CCC([O-])=O

InChI

InChIKey=ZDQYSKICYIVCPN-UHFFFAOYSA-L
InChI=1S/C4H6O4.2Na/c5-3(6)1-2-4(7)8;;/h1-2H2,(H,5,6)(H,7,8);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/23461009 | https://www.ncbi.nlm.nih.gov/pubmed/24771373 | https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=PB254541 | https://www.ncbi.nlm.nih.gov/pubmed/10464017

Succinic acid is a dicarboxylic acid, which has multiple biological roles as a metabolic intermediate being converted into fumarate by the enzyme succinate dehydrogenase in complex 2 of the electron transport chain which is involved in making ATP, and as a signaling molecule reflecting the cellular metabolic state. Succinate is generated in mitochondria via the tricarboxylic acid cycle (TCA), an energy-yielding process shared by all organisms. Succinate can exit the mitochondrial matrix and function in the cytoplasm as well as the extracellular space, changing gene expression patterns, modulating epigenetic landscape or demonstrating hormone-like signaling. Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leigh's disease, and Mela's disease and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury. Succinic acid is a precursor to some polyesters and a component of some alkyd resins. Succinic acid also serves as the bases of certain biodegradable polymers, which are of interest in tissue engineering applications. As a food additive and dietary supplement, succinic acid is generally recognized as safe by the U.S. Food and Drug Administration. Succinic acid is used primarily as an acidity regulator in the food and beverage industry. It is also available as a flavoring agent, contributing a somewhat sour and astringent component to umami taste.[11] As an excipient in pharmaceutical products, it is also used to control acidity or as a counter ion. Drugs involving succinate include metoprolol succinate, sumatriptan succinate, Doxylamine succinate or solifenacin succinate.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
3.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Reamberin

Approved Use

Unknown
Inactive ingredient
Metoprolol Succinate ER

Approved Use

Unknown
Inactive ingredient
VESIcare

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds.
1999 Aug 26
Structures and proton-pumping strategies of mitochondrial respiratory enzymes.
2001
Respiratory enzymes from Sulfolobus acidocaldarius.
2001
Ultrastructural localization of succinate dehydrogenase in some bacteria, after treatment with Lubrol W1.
2001
The effects of feed and intracellular pyruvate levels on the redistribution of metabolic fluxes in Escherichia coli.
2001 Apr
Towards developing a non-SnCl2 formulation for RP444, a new radiopharmaceutical for thrombus imaging.
2001 Feb
Time-course changes in arteriolar and venular portions of capillary in young treadmill-trained rats.
2001 Jan
Developmental aspects of the rat endolymphatic sac and functional implications.
2001 Jan
Succinic acid production with reduced by-product formation in the fermentation of Anaerobiospirillum succiniciproducens using glycerol as a carbon source.
2001 Jan 5
Succinic dehydrogenase histochemistry as an early marker for hair cell pathology.
2001 Jan-Feb
Tissue reactions to epoxy-crosslinked porcine heart valves post-treated with detergents or a dicarboxylic acid.
2001 Jun 5
Metabolic enzymes and phenotypic expression among human locomotor muscles.
2001 Mar
Effects of culture conditions on enhancement of 2,4-dinitrotoluene degradation by Burkholderia engineered with the Vitreoscilla hemoglobin gene.
2001 Mar-Apr
Possible involvement of protein phosphorylation in aluminum-responsive malate efflux from wheat root apex.
2001 May
The Quinone-binding sites of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase.
2001 May 18
Patents

Sample Use Guides

Human: 0.20mh/kg/day up tp 12.2mg
Route of Administration: Oral
Antiviral activity was measured in a plaque inhibition assay. Confluent Vero cell monolayer in 6-well multidishes were infected with 100 PFU in 1 mL of MEM medium. After adsorption at 37 °C for 2 h, residual inoculum was replaced with 1 mL of MEM medium containing 0.2% gamma-globulin and 1 mL of a dilution of varying concentrations of the Succinic acid. Virus-infected wells without compounds were used as cytopathogenicity controls. Viral cytopathogenicity (CPE) was completed 1-2 days after viral infection
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:04:43 GMT 2023
Edited
by admin
on Fri Dec 15 16:04:43 GMT 2023
Record UNII
V8ZGC8ISR3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM SUCCINATE ANHYDROUS
Common Name English
FEMA NO. 3277
Code English
DISODIUM SUCCINATE [INCI]
Common Name English
SODIUM SUCCINATE [MART.]
Common Name English
DISODIUM BUTANEDIOATE
Systematic Name English
SODIUM SUCCINATE [MI]
Common Name English
ANHYDROUS SODIUM SUCCINATE [USP-RS]
Common Name English
SODIUM SUCCINATE, ANHYDROUS
Common Name English
SUCCINATE SODIUM
WHO-DD  
Systematic Name English
DISODIUM SUCCINATE
FHFI   INCI  
INCI  
Official Name English
Succinate sodium [WHO-DD]
Common Name English
BUTANEDIOIC ACID DISODIUM SALT
Common Name English
DISODIUM SUCCINATE [FHFI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C345
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
Code System Code Type Description
SMS_ID
100000085549
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
ECHA (EC/EINECS)
237-884-4
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
ALTERNATIVE
RS_ITEM_NUM
1614716
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
FDA UNII
V8ZGC8ISR3
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
CAS
14047-56-4
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
NON-SPECIFIC STOICHIOMETRY
EVMPD
SUB12593MIG
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
EVMPD
SUB20439
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
DAILYMED
V8ZGC8ISR3
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
MERCK INDEX
m10078
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY Merck Index
RXCUI
1307107
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY RxNorm
PUBCHEM
9020
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-778-7
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
CAS
150-90-3
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
CHEBI
63675
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
EPA CompTox
DTXSID5059741
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
NCI_THESAURUS
C84169
Created by admin on Fri Dec 15 16:04:43 GMT 2023 , Edited by admin on Fri Dec 15 16:04:43 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY