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Details

Stereochemistry ACHIRAL
Molecular Formula C4H4O4.2Na.6H2O
Molecular Weight 270.1434
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM SUCCINATE HEXAHYDRATE

SMILES

O.O.O.O.O.O.[Na+].[Na+].[O-]C(=O)CCC([O-])=O

InChI

InChIKey=ZBTUYCUNQBRXOR-UHFFFAOYSA-L
InChI=1S/C4H6O4.2Na.6H2O/c5-3(6)1-2-4(7)8;;;;;;;;/h1-2H2,(H,5,6)(H,7,8);;;6*1H2/q;2*+1;;;;;;/p-2

HIDE SMILES / InChI

Molecular Formula C4H6O4
Molecular Weight 118.088
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/23461009 | https://www.ncbi.nlm.nih.gov/pubmed/24771373 | https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=PB254541 | https://www.ncbi.nlm.nih.gov/pubmed/10464017

Succinic acid is a dicarboxylic acid, which has multiple biological roles as a metabolic intermediate being converted into fumarate by the enzyme succinate dehydrogenase in complex 2 of the electron transport chain which is involved in making ATP, and as a signaling molecule reflecting the cellular metabolic state. Succinate is generated in mitochondria via the tricarboxylic acid cycle (TCA), an energy-yielding process shared by all organisms. Succinate can exit the mitochondrial matrix and function in the cytoplasm as well as the extracellular space, changing gene expression patterns, modulating epigenetic landscape or demonstrating hormone-like signaling. Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leigh's disease, and Mela's disease and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury. Succinic acid is a precursor to some polyesters and a component of some alkyd resins. Succinic acid also serves as the bases of certain biodegradable polymers, which are of interest in tissue engineering applications. As a food additive and dietary supplement, succinic acid is generally recognized as safe by the U.S. Food and Drug Administration. Succinic acid is used primarily as an acidity regulator in the food and beverage industry. It is also available as a flavoring agent, contributing a somewhat sour and astringent component to umami taste.[11] As an excipient in pharmaceutical products, it is also used to control acidity or as a counter ion. Drugs involving succinate include metoprolol succinate, sumatriptan succinate, Doxylamine succinate or solifenacin succinate.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
3.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Reamberin

Approved Use

Unknown
Inactive ingredient
Metoprolol Succinate ER

Approved Use

Unknown
Inactive ingredient
VESIcare

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Structures and proton-pumping strategies of mitochondrial respiratory enzymes.
2001
[Intermittent hypoxic training with exogenous nitric oxide improves rat liver mitochondrial oxidation and phosphorylation during acute hypoxia].
2001
Respiratory enzymes from Sulfolobus acidocaldarius.
2001
Synthesis of ethyl alkylidene alpha cyanoacetates under ultrasound irradiation.
2001 Apr
Rat liver microsomal lipid peroxidation produced during the oxidative metabolism of ethacrynic acid.
2001 Apr
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.
2001 Apr
Combined effect of propofol and GSNO on oxidative phosphorylation of isolated rat liver mitochondria.
2001 Apr
The effects of endurance training and exhaustive exercise on mitochondrial enzymes in tissues of the rat (Rattus norvegicus).
2001 Apr
Glutamine supplementation promotes anaplerosis but not oxidative energy delivery in human skeletal muscle.
2001 Apr
Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain.
2001 Apr
Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.
2001 Apr 1
Germline SDHD mutation in familial phaeochromocytoma.
2001 Apr 14
Probing the active site of L-aspartate oxidase by site-directed mutagenesis: role of basic residues in fumarate reduction.
2001 Apr 17
Energetic metabolism in mouse cerebral cortex during chronic hypoxia.
2001 Apr 6
New insights into the regulation of plant succinate dehydrogenase. On the role of the protonmotive force.
2001 Aug 31
A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region.
2001 Feb
Metabolic shifts and myocyte hypertrophy in deflazacort treatment of mdx mouse cardiomyopathy.
2001 Feb
In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data.
2001 Feb
Kynurenic acid influences the respiratory parameters of rat heart mitochondria.
2001 Feb
Aerobic metabolism of human quadriceps muscle: in vivo data parallel measurements on isolated mitochondria.
2001 Feb
"Chemical preconditioning" by 3-nitropropionate reduces ischemia-reperfusion injury in cardiac-arrested rat lungs.
2001 Feb 15
Dimeric pig heart succinate-coenzyme A transferase uses only one subunit to support catalysis.
2001 Feb 27
Time-course changes in arteriolar and venular portions of capillary in young treadmill-trained rats.
2001 Jan
Developmental aspects of the rat endolymphatic sac and functional implications.
2001 Jan
Adenine and guanine nucleotide-specific succinyl-CoA synthetases in the clonal beta-cell mitochondria: implications in the beta-cell high-energy phosphate metabolism in relation to physiological insulin secretion.
2001 Jan
Reactivity of some sugars and sugar phosphates towards gold(III) in sodium acetate-acetic acid buffer medium.
2001 Jan 15
Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin.
2001 Jan 15
Changes in various measures of immune status in mice subject to chronic social conflict.
2001 Jan-Feb
Simultaneous chromium(VI) reduction and phenol degradation in a fixed-film coculture bioreactor: reactor performance.
2001 Jun
Ubiquinol:cytochrome c oxidoreductase (complex III). Effect of inhibitors on cytochrome b reduction in submitochondrial particles and the role of ubiquinone in complex III.
2001 Jun 1
Kinetic analyses of mitochondrial 75selenium uptake in Trigonella foenum-graecum seedlings exposed to selenium and mimosine.
2001 Mar
Metabolic enzymes and phenotypic expression among human locomotor muscles.
2001 Mar
A general method for the quantitative analysis of functional chimeras: applications from site-directed mutagenesis and macromolecular association.
2001 Mar
A third crystal form of Wolinella succinogenes quinol:fumarate reductase reveals domain closure at the site of fumarate reduction.
2001 Mar
Depletion of glutathione up-regulates mitochondrial complex I expression in glial cells.
2001 Mar
Barth's syndrome-like disorder: a new phenotype with a maternally inherited A3243G substitution of mitochondrial DNA (MELAS mutation).
2001 Mar 1
The simplest supramolecular complexes containing pairs of Mo(2)(formamidinate)(3) units linked with various dicarboxylates: preparative methods, structures, and electrochemistry.
2001 Mar 12
Isolation and phenotypic characterization of Pseudomonas aeruginosa pseudorevertants containing suppressors of the catabolite repression control-defective crc-10 allele.
2001 Mar 15
Disruption of mitochondrial respiration by melatonin in MCF-7 cells.
2001 Mar 15
Myxothiazol induces H(2)O(2) production from mitochondrial respiratory chain.
2001 Mar 2
Topology of the Na(+)/dicarboxylate cotransporter: the N-terminus and hydrophilic loop 4 are located intracellularly.
2001 Mar 9
Dynamic responses of Pseudomonas fluorescens DF57 to nitrogen or carbon source addition.
2001 Mar 9
Possible involvement of protein phosphorylation in aluminum-responsive malate efflux from wheat root apex.
2001 May
Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells.
2001 May
Chemical preconditioning with 3-nitropropionic acid in hearts: role of mitochondrial K(ATP) channel.
2001 May
Cloning and functional characterization of a high-affinity Na(+)/dicarboxylate cotransporter from mouse brain.
2001 May
Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS).
2001 May 18
The Quinone-binding sites of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase.
2001 May 18
The 'strict' anaerobe Desulfovibrio gigas contains a membrane-bound oxygen-reducing respiratory chain.
2001 May 4
In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation.
2001 May 4
Patents

Sample Use Guides

Human: 0.20mh/kg/day up tp 12.2mg
Route of Administration: Oral
Antiviral activity was measured in a plaque inhibition assay. Confluent Vero cell monolayer in 6-well multidishes were infected with 100 PFU in 1 mL of MEM medium. After adsorption at 37 °C for 2 h, residual inoculum was replaced with 1 mL of MEM medium containing 0.2% gamma-globulin and 1 mL of a dilution of varying concentrations of the Succinic acid. Virus-infected wells without compounds were used as cytopathogenicity controls. Viral cytopathogenicity (CPE) was completed 1-2 days after viral infection
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:00:03 GMT 2023
Edited
by admin
on Fri Dec 15 15:00:03 GMT 2023
Record UNII
U16QOD6C4E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM SUCCINATE HEXAHYDRATE
II   MI  
Systematic Name English
DISODIUM BUTANEDIOATE HEXAHYDRATE
Systematic Name English
SODIUM SUCCINATE
INCI   ORANGE BOOK   VANDF  
INCI  
Official Name English
SODIUM SUCCINATE HEXAHYDRATE [MI]
Common Name English
SODIUM SUCCINATE [INCI]
Common Name English
SODIUM SUCCINATE HEXAHYDRATE [II]
Common Name English
BUTANEDIOIC ACID DISODIUM SALT HEXAHYDRATE
Common Name English
SODIUM SUCCINATE [VANDF]
Common Name English
DISODIUM SUCCINATE HEXAHYDRATE
Systematic Name English
SODIUM SUCCINATE [ORANGE BOOK]
Common Name English
SUCCINIC ACID DISODIUM SALT
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C345
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
Code System Code Type Description
CHEBI
63686
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
DRUG CENTRAL
5200
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
PUBCHEM
3083938
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
RXCUI
1311370
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
ALTERNATIVE
EVMPD
SUB12662MIG
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
MERCK INDEX
m10078
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C66554
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
SMS_ID
100000078266
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
CHEBI
63675
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
EVMPD
SUB12593MIG
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
CAS
6106-21-4
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
EPA CompTox
DTXSID70209942
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
RXCUI
1311369
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
FDA UNII
U16QOD6C4E
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
DAILYMED
U16QOD6C4E
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
ChEMBL
CHEMBL1200345
Created by admin on Fri Dec 15 15:00:03 GMT 2023 , Edited by admin on Fri Dec 15 15:00:03 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
ANHYDROUS->SOLVATE
Related Record Type Details
ACTIVE MOIETY