Tinocabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 17:22:41 GMT 2025` Edited by `admin` on `Wed Apr 02 17:22:41 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE ATTENUATED GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	cd4+ and cd8+ enriched t lymphocytes
Record UNII	V3JBG9247U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Autologous T lymphocytes obtained from peripheral blood lymphocytes by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector, encoding a bispecific chimeric antigen receptor targeting CD19 and CD22 (Siglec-2). The expresse

Preferred Name

English

Tinocabtagene Autoleucel

Official Name

English

tinocabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

V3JBG9247U

Created by admin on Wed Apr 02 17:22:41 GMT 2025 , Edited by admin on Wed Apr 02 17:22:41 GMT 2025

PRIMARY

NCI_THESAURUS

C199018

Created by admin on Wed Apr 02 17:22:41 GMT 2025 , Edited by admin on Wed Apr 02 17:22:41 GMT 2025

PRIMARY

INN

12483

Created by admin on Wed Apr 02 17:22:41 GMT 2025 , Edited by admin on Wed Apr 02 17:22:41 GMT 2025

PRIMARY

Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:


					RCH7C9TW12

B-CELL RECEPTOR CD22

TARGET->LIGAND

Amount:


					P050J5FWC5

INTERFERON GAMMA

CONSTITUENT ALWAYS PRESENT -> PARENT

Amount:

Related Record Type Details


					V3JBG9247U

Tinocabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Tinocabtagene autoleucel lentiviral vector	C2C748J4VR
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217
CULTURE	ACTIVATOR	BIOLOGICAL	ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Tinocabtagene autoleucel transgene insert	N38C7QAA5W
VECTOR EXPRESSED PROTEIN					Tinocabtagene autoleucel expressed bispecific chimeric antigen receptor targeting CD19 and CD22	HC7DQ3DC72