Temtokibart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:03:52 GMT 2025` Edited by `admin` on `Wed Apr 02 11:03:52 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	V2XME9F5SF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IL-22R

Preferred Name

English

Temtokibart

Official Name

English

clone 230C9

Code

English

TEMTOKIBART [USAN]

Common Name

English

temtokibart [INN]

Common Name

English

LEO138559

Code

English

immunoglobulin G1-lambda2, anti-[Homo sapiens IL22RA1 interleukin 22 receptor subunit alpha 1, IL22R)], humanized monoclonal antibody (gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-NL1*01 (89.8%) -(IGHD) -IGHJ5*01(92.3%), CDR-IMGT [8.8.13]

Common Name

English

LEO-138559

Code

English

Immunoglobulin G1 [300-glutamine], anti-(human interleukin 22 receptor) (human-Lama glama monoclonal LEO 138559 ?1-chain), disulfide with human-Lama glama monoclonal LEO 138559 ?-chain, dimer

Common Name

English

Code System Code Type Description

FDA UNII

V2XME9F5SF

Created by admin on Wed Apr 02 11:03:52 GMT 2025 , Edited by admin on Wed Apr 02 11:03:52 GMT 2025

PRIMARY

INN

12231

Created by admin on Wed Apr 02 11:03:52 GMT 2025 , Edited by admin on Wed Apr 02 11:03:52 GMT 2025

PRIMARY

USAN

MN-12

Created by admin on Wed Apr 02 11:03:52 GMT 2025 , Edited by admin on Wed Apr 02 11:03:52 GMT 2025

PRIMARY

NCI_THESAURUS

C199119

Created by admin on Wed Apr 02 11:03:52 GMT 2025 , Edited by admin on Wed Apr 02 11:03:52 GMT 2025

PRIMARY

CAS

2639874-57-8

Created by admin on Wed Apr 02 11:03:52 GMT 2025 , Edited by admin on Wed Apr 02 11:03:52 GMT 2025

PRIMARY

SMS_ID

300000045007

Created by admin on Wed Apr 02 11:03:52 GMT 2025 , Edited by admin on Wed Apr 02 11:03:52 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_223	4_208
2_264	2_324
1_147	1_203
2_370	2_428
3_22	3_83
3_131	3_190
4_22	4_83
4_131	4_190
1_223	3_208
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Related Record Type Details


					V2XME9F5SF

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_450] [2_450]				LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL