Tizetatug Rezetecan

Investigational

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	UJR3SD8NLS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tizetatug Rezetecan

Official Name

English

H-gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV1-69*02 (88.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.14] (26-35.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (218) (122-219), hinge 1-15 (22

Preferred Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens TACSTD2 (tumor-associated calcium signal transducer 2, membrane component chromosome 1 surface marker 1, M1S1, gastrointestinal tumor-associated antigen GA7331, pancreatic carcinoma marker protein GA733-1, epit

Common Name

English

Immunoglobulin G1, anti-(human tumor-associated calcium signal transducer 2) (human-Mus musculus monoclonal HRP02606 ?1-chain), human-Mus musculus monoclonal HRP02606 ?-chain, dimer, reduced, tetrakis(thioether) with (2S)-N-[6-(3-mercapto-2,5-dioxo-1-pyr

Common Name

English

tizetatug rezetecan [INN]

Common Name

English

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Code System

Code

Type

Description

SMS_ID

300000056834

PRIMARY

CAS

2938864-88-9

PRIMARY

NCI_THESAURUS

C211811

PRIMARY

FDA UNII

UJR3SD8NLS

PRIMARY

INN

13287

PRIMARY

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From	To
1_22	1_96
2_22	2_96
2_148	2_204
2_224	4_214
2_265	2_325

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Glycosylation Type

MAMMALIAN

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Glycosylation Link Type	Site
N	1_301
N	2_301

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Related Record

Type

Details


					GM1W90Y88M

TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER 2

TARGET->LIGAND

Amount:


					PCX6SM5JNT

Tizetatug

PARENT -> CONJUGATE

Amount:


					FUV56ZH0GB

DNA TOPOISOMERASE 1

TARGET -> INHIBITOR

Amount:

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Related Record

Type

Details


					UJR3SD8NLS

Tizetatug Rezetecan

ACTIVE MOIETY

Amount:

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_451] [2_451]	C-TERMINUS	K	Amount: [98.6 to 98.8] % (average) C-Terminal Lysine removal range from 3 different lots	LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q	Amount: [4 to 4.5] % (average) N-terminal pyroGlu range from 3 different lots	PIDOLIC ACID	SZB83O1W42
AMINO_ACID_SUBSTITUTION	[1_224] [1_230] [1_233] [2_224] [2_230] [2_233] [3_214] [4_214]	SITE_SPECIFIC	C	Amount: [3.6 to 4.8] PER PROTEIN (average) antibody conjugation ratio (DAR)	UNSPECIFIED SUBSTANCE	a9e52966 (not in database)

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C6502H10032N1696O2016S40
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 145500.034 Da (average)

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