FLUORESCEIN LISICOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C51H63N3O11S
Molecular Weight	926.124
Optical Activity	UNSPECIFIED
Defined Stereocenters	12 / 12
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)[C@H](C)CCC(=O)N[C@@H](CCCCNC(=S)NC5=CC6=C(C=C5)C7(OC6=O)C8=C(OC9=C7C=CC(O)=C9)C=C(O)C=C8)C(O)=O

InChI

InChIKey=KHNJPPGHIWPDLG-DXNXUNFASA-N

InChI=1S/C51H63N3O11S/c1-26(33-14-15-37-45-38(25-43(59)50(33,37)3)49(2)18-17-31(57)20-27(49)21-40(45)58)7-16-44(60)54-39(46(61)62)6-4-5-19-52-48(66)53-28-8-11-34-32(22-28)47(63)65-51(34)35-12-9-29(55)23-41(35)64-42-24-30(56)10-13-36(42)51/h8-13,22-24,26-27,31,33,37-40,43,45,55-59H,4-7,14-21,25H2,1-3H3,(H,54,60)(H,61,62)(H2,52,53,66)/t26-,27+,31-,33-,37+,38+,39+,40-,43+,45+,49+,50-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C51H63N3O11S
Molecular Weight	926.124
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	11 / 12
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25997548 | https://www.drugbank.ca/drugs/DB12030

Fluorescein Lisicol (NRL972) is a fluorescent-labelled bile acid analog that is used as an investigational marker for liver function, specifically hepatic biliary transporter function. Fluorescein Lisicol has been used in trials investigating the pharmacokinetics of hepatic cirrhosis, viral hepatitis, non-alcoholic steatohepatitis and non-alcoholic fatty liver disease.

Approval Year

PubMed

Title	Date	PubMed
Gateways to clinical trials.	2004 Sep	15538546
Effects of renal insufficiency on the elimination of fluorescein lisicol (NRL972), an investigational marker of hepatic transporter function.	2015 Jul	25997548

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:20:48 UTC 2023` Edited by `admin` on `Sat Dec 16 17:20:48 UTC 2023`
Record UNII	U7GBB0934J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUORESCEIN LISICOL

Official Name

English

CHOLYL-LYSL-FLUORESCEIN

Common Name

English

BENZOIC ACID, 5-(((((5S)-5-CARBOXY-5-(((3.ALPHA.,5.BETA.,7.ALPHA.,12.ALPHA.)-3,7,12-TRIHYDROXY-24-OXOCHOLAN-24-YL)AMINO)PENTYL)AMINO)THIOXOMETHYL)AMINO)-2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-

Common Name

English

NRL-972

Code

English

L-LYSINE, N6-(((3',6'-DIHYDROXY-3-OXOSPIRO(ISOBENZOFURAN-1(3H),9'-(9H)XANTHEN)-5-YL)AMINO)THIOXOMETHYL)-N2-((3.ALPHA.,5.BETA.,7.ALPHA.,12.ALPHA.)-3,7,12-TRIHYDROXY-24-OXOCHOLAN-24-YL)-

Common Name

English

fluorescein lisicol [INN]

Common Name

English

NRL972

Code

English

Code System Code Type Description

NCI_THESAURUS

C169991