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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H17NO2
Molecular Weight 267.323
Optical Activity ( - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIHYDREXIDINE, (-)-

SMILES

c1ccc2c(c1)CN[C@@]3([H])CCc4cc(c(cc4[C@]23[H])O)O

InChI

InChIKey=BGOQGUHWXBGXJW-YOEHRIQHSA-N
InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m0/s1

HIDE SMILES / InChI

Molecular Formula C17H17NO2
Molecular Weight 267.323
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. Dihydrexidine was shown to stimulate cyclic AMP synthesis just as well or better than dopamine. It was the first dopamine D1 receptor agonist that had potent antiparkinsonian activity in a primate model of Parkinson's disease. Dihydrexidine produces hypothermia. Dihydrexidine has been shown to alleviate cognitive deficits or enhance cognitive performance in a number of animal models of cognition. It is under investigation for the improving the cognitive and working memory deficits in schizophrenia and schizotypal disorder.

Approval Year

PubMed

PubMed

TitleDatePubMed
Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase.
2001 Feb
Patents

Patents

Sample Use Guides

20 mg over 15 min
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Sat Jun 26 15:45:45 UTC 2021
Edited
by admin
on Sat Jun 26 15:45:45 UTC 2021
Record UNII
U4MPC92UC2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIHYDREXIDINE, (-)-
Common Name English
BENZO(A)PHENANTHRIDINE-10,11-DIOL, 5,6,6A,7,8,12B-HEXAHYDRO-, (6AS,12BR)-
Systematic Name English
DAR-0100A
Code English
DAR0100A
Code English
BENZO(A)PHENANTHRIDINE-10,11-DIOL, 5,6,6A,7,8,12B-HEXAHYDRO-, (6AS-TRANS)-
Systematic Name English
(6AS,12BR)-5,6,6A,7,8,12B-HEXAHYDROBENZO(A)PHENANTHRIDINE-10,11-DIOL
Systematic Name English
(-)-DIHYDREXIDINE
Common Name English
Code System Code Type Description
CAS
757161-85-6
Created by admin on Sat Jun 26 15:45:45 UTC 2021 , Edited by admin on Sat Jun 26 15:45:45 UTC 2021
PRIMARY
FDA UNII
U4MPC92UC2
Created by admin on Sat Jun 26 15:45:45 UTC 2021 , Edited by admin on Sat Jun 26 15:45:45 UTC 2021
PRIMARY
PUBCHEM
5311070
Created by admin on Sat Jun 26 15:45:45 UTC 2021 , Edited by admin on Sat Jun 26 15:45:45 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
INNOVATOR->PARENT
ENANTIOMER -> ENANTIOMER
RACEMATE -> ENANTIOMER
Related Record Type Details
ACTIVE MOIETY