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Details

Stereochemistry RACEMIC
Molecular Formula C17H17NO2
Molecular Weight 267.323
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIHYDREXIDINE

SMILES

c1ccc2c(c1)CN[C@@]3([H])CCc4cc(c(cc4[C@]23[H])O)O

InChI

InChIKey=BGOQGUHWXBGXJW-YOEHRIQHSA-N
InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m0/s1

HIDE SMILES / InChI

Molecular Formula C17H17NO2
Molecular Weight 267.323
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. Dihydrexidine was shown to stimulate cyclic AMP synthesis just as well or better than dopamine. It was the first dopamine D1 receptor agonist that had potent antiparkinsonian activity in a primate model of Parkinson's disease. Dihydrexidine produces hypothermia. Dihydrexidine has been shown to alleviate cognitive deficits or enhance cognitive performance in a number of animal models of cognition. It is under investigation for the improving the cognitive and working memory deficits in schizophrenia and schizotypal disorder.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

20 mg over 15 min
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Sat Jun 26 15:45:47 UTC 2021
Edited
by admin
on Sat Jun 26 15:45:47 UTC 2021
Record UNII
32D64VH037
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIHYDREXIDINE
Common Name English
BENZO(A)PHENANTHRIDINE-10,11-DIOL, 5,6,6A,7,8,12B-HEXAHYDRO-, HYDROCHLORIDE (1:1), (6AR,12BS)-REL-
Systematic Name English
BENZO(A)PHENANTHRIDINE-10,11-DIOL, 5,6,6A,7,8,12B-HEXAHYDRO-, TRANS-
Common Name English
BENZO(A)PHENANTHRIDINE-10,11-DIOL, 5,6,6A,7,8,12B-HEXAHYDRO-, HYDROCHLORIDE (1:1), (6ARS,12BSR)-, (+/-)-
Common Name English
REL-(6AR,12BS)-5,6,6A,7,8,12B-HEXAHYDROBENZO(A)PHENANTHRIDINE-10,11-DIOL
Common Name English
Code System Code Type Description
CAS
123039-93-0
Created by admin on Sat Jun 26 15:45:48 UTC 2021 , Edited by admin on Sat Jun 26 15:45:48 UTC 2021
PRIMARY
FDA UNII
32D64VH037
Created by admin on Sat Jun 26 15:45:48 UTC 2021 , Edited by admin on Sat Jun 26 15:45:48 UTC 2021
PRIMARY
DRUG BANK
DB12890
Created by admin on Sat Jun 26 15:45:48 UTC 2021 , Edited by admin on Sat Jun 26 15:45:48 UTC 2021
PRIMARY
MESH
C061532
Created by admin on Sat Jun 26 15:45:48 UTC 2021 , Edited by admin on Sat Jun 26 15:45:48 UTC 2021
PRIMARY
WIKIPEDIA
DIHYDREXIDINE
Created by admin on Sat Jun 26 15:45:48 UTC 2021 , Edited by admin on Sat Jun 26 15:45:48 UTC 2021
PRIMARY
Related Record Type Details
ACTIVE ISOMER -> PARENT
In vitro, this isomer has 125-fold higher affinity for D1 receptors than the (?) enantiomer
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE