Alcestobart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:11:27 GMT 2025` Edited by `admin` on `Wed Apr 02 06:11:27 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	U1GA9GN97D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-gamma4 heavy chain Homo sapiens (1-439) [VH (Homo sapiens IGHV3-20*04 (91.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.5] (26-33.51-58.97-101)) (1-112) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10(CH1 (113-210), hinge 1-12 S10>P (220) (211-222),

Preferred Name

English

Alcestobart

Official Name

English

alcestobart [INN]

Common Name

English

Code System Code Type Description

CAS

2888563-73-1

Created by admin on Wed Apr 02 06:11:27 GMT 2025 , Edited by admin on Wed Apr 02 06:11:27 GMT 2025

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FDA UNII

U1GA9GN97D

Created by admin on Wed Apr 02 06:11:27 GMT 2025 , Edited by admin on Wed Apr 02 06:11:27 GMT 2025

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INN

13148

Created by admin on Wed Apr 02 06:11:27 GMT 2025 , Edited by admin on Wed Apr 02 06:11:27 GMT 2025

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NCI_THESAURUS

C179260

Created by admin on Wed Apr 02 06:11:27 GMT 2025 , Edited by admin on Wed Apr 02 06:11:27 GMT 2025

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SMS_ID

300000046247

Created by admin on Wed Apr 02 06:11:27 GMT 2025 , Edited by admin on Wed Apr 02 06:11:27 GMT 2025

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From	To
4_135	4_195
4_23	4_88
3_135	3_195
3_23	3_88
2_359	2_417
2_253	2_313
2_139	2_195
2_126	4_215
2_22	2_96
1_359	1_417
1_253	1_313
1_221	2_221
1_218	2_218
1_139	1_195
1_126	3_215
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_289
N	2_289

Related Record Type Details


					U1GA9GN97D

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_439] [2_439]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q	Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL