DROPROPIZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H20N2O2
Molecular Weight	236.3101
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCC(O)CN1CCN(CC1)C2=CC=CC=C2

InChI

InChIKey=PTVWPYVOOKLBCG-UHFFFAOYSA-N

InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2

HIDE SMILES / InChI

Molecular Formula	C13H20N2O2
Molecular Weight	236.3101
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1295724
Curator's Comment: Description was created based on several sources, including https://www.epharmapedia.com/medicine/profile/193457/Troferit.html?lang=en&tab=druginfo https://www.ncbi.nlm.nih.gov/pubmed/7649341

Dropropizine is a cough suppressant. It has peripheral action in non-productive cough. Dropropizine is commercialized in Latin American and African countries.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4401506 http://www.druginfosys.com/drug.aspx?drugcode=1578&type=1	Primary		Approved 8429	TROFERIT Approved Use Dropropizine is primarily indicated in conditions like Non-productive cough.

PubMed

Title	Date	PubMed
Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae).	2003	13678247
Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.	2003 Dec 25	14643514
Antitussive effect of diltiazem in experimental conditions.	2004	15535110
Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.	2004 Aug	15257075
The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.	2009	19507659
Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.	2010	20671996
Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.	2013 Dec	24085318

Patents

Sample Use Guides

In Vivo Use Guide

30 mg 6 or 8 hourly

Route of Administration: Oral

In Vitro Use Guide

When the Chinese hamster V79 cells were treated with the highest concentration of Dropropizine (8000 ug/ml), cytostatic effects lasting 24 h were observed

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:11:04 UTC 2023` Edited by `admin` on `Sat Dec 16 17:11:04 UTC 2023`
Record UNII	U0K8WHL37U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DROPROPIZINE

Official Name

English

DIPROPIZINE

Common Name

English

RIBEX

Brand Name

English

DROPROPIZINE [MI]

Common Name

English

1,2-PROPANEDIOL, 3-(4-PHENYL-1-PIPERAZINYL)-

Systematic Name

English

CATABEX

Brand Name

English

dropropizine [INN]

Common Name

English

LARYLIN

Brand Name

English

DROPROPIZINE [MART.]

Common Name

English

KATRIL

Brand Name

English

(±)-DROPROPIZINE

Common Name

English

U.C.B.-1967

Code

English

NSC-757820

Code

English

DOPROPIZIN

Common Name

English

UCB 1967

Code

English

UCB-1967

Code

English

DITUSTAT

Brand Name

English

Dropropizine [WHO-DD]

Common Name

English

3-(4-PHENYL-1-PIPERAZINYL)-1,2-PROPANEDIOL

Systematic Name

English

TUSSILEX

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29698