DROPROPIZINE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H20N2O2
Molecular Weight	236.3101
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

OCC(O)CN1CCN(CC1)C2=CC=CC=C2

InChI

InChIKey=PTVWPYVOOKLBCG-UHFFFAOYSA-N

InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2

HIDE SMILES / InChI

Molecular Formula	C13H20N2O2
Molecular Weight	236.3101
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Dropropizine is a cough suppressant. It has peripheral action in non-productive cough. Dropropizine is commercialized in Latin American and African countries.

CNS Activity

Originator

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106	Primary		Approved 8,429	TROFERIT

PubMed

Show entries

Title	Date	PubMed
Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae).	2003	13678247
Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.	2003 Dec 25	14643514
The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.	2009	19507659
Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.	2010	20671996
Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.	2013 Dec	24085318

Showing 1 to 5 of 5 entries

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Patents

Sample Use Guides

In Vivo Use Guide

30 mg 6 or 8 hourly

Route of Administration: Oral

In Vitro Use Guide

When the Chinese hamster V79 cells were treated with the highest concentration of Dropropizine (8000 ug/ml), cytostatic effects lasting 24 h were observed