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Details

Stereochemistry RACEMIC
Molecular Formula C13H20N2O2.ClH
Molecular Weight 272.771
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DROPROPIZINE HYDROCHLORIDE

SMILES

Cl.OCC(O)CN1CCN(CC1)C2=CC=CC=C2

InChI

InChIKey=QBZODDIRPJEEQW-UHFFFAOYSA-N
InChI=1S/C13H20N2O2.ClH/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12;/h1-5,13,16-17H,6-11H2;1H

HIDE SMILES / InChI
Molecular Formula C13H20N2O2
Molecular Weight 236.3101
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.epharmapedia.com/medicine/profile/193457/Troferit.html?lang=en&tab=druginfo https://www.ncbi.nlm.nih.gov/pubmed/7649341

Dropropizine is a cough suppressant. It has peripheral action in non-productive cough. Dropropizine is commercialized in Latin American and African countries.

CNS Activity

Originator

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
TROFERIT

Approved Use

Dropropizine is primarily indicated in conditions like Non-productive cough.
Doses

Doses

DosePopulationAdverse events​
90 mg single, oral
Studied dose
Dose: 90 mg
Route: oral
Route: single
Dose: 90 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/4401506/
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/4401506/
Sources:
https://pubmed.ncbi.nlm.nih.gov/4401506/
1 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 1 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 1 mg/kg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7649341/
unhealthy, CHILD
Health Status: unhealthy
Age Group: CHILD
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/7649341/
Disc. AE: Somnolence...
AEs leading to
discontinuation/dose reduction:
Somnolence (grade 3, 0.79%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/7649341/
AEs

AEs

AESignificanceDosePopulation
Somnolence grade 3, 0.79%
Disc. AE
1 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 1 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 1 mg/kg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7649341/
unhealthy, CHILD
Health Status: unhealthy
Age Group: CHILD
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/7649341/
PubMed

PubMed

TitleDatePubMed
Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.
2013-12
Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.
2010
The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.
2009
Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.
2004-08
Antitussive effect of diltiazem in experimental conditions.
2004
Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.
2003-12-25
Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae).
2003
Patents

Patents

EP0349066A1
2
US4699911
2

Sample Use Guides

In Vivo Use Guide
Curator's Comment: can also be used rectally http://www.ndrugs.com/?s=troferit
30 mg 6 or 8 hourly
Route of Administration: Oral
In Vitro Use Guide
When the Chinese hamster V79 cells were treated with the highest concentration of Dropropizine (8000 ug/ml), cytostatic effects lasting 24 h were observed
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:17:28 GMT 2025
Edited
by admin
on Mon Mar 31 23:17:28 GMT 2025
Record UNII
30H39EX30A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
1,2-PROPANEDIOL, 3-(4-PHENYL-1-PIPERAZINYL)-, HYDROCHLORIDE
Preferred Name English
DROPROPIZINE HYDROCHLORIDE
Common Name English
1,2-PROPANEDIOL, 3-(4-PHENYL-1-PIPERAZINYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
Code System Code Type Description
PUBCHEM
126961373
Created by admin on Mon Mar 31 23:17:28 GMT 2025 , Edited by admin on Mon Mar 31 23:17:28 GMT 2025
PRIMARY
CAS
857188-77-3
Created by admin on Mon Mar 31 23:17:28 GMT 2025 , Edited by admin on Mon Mar 31 23:17:28 GMT 2025
PRIMARY
FDA UNII
30H39EX30A
Created by admin on Mon Mar 31 23:17:28 GMT 2025 , Edited by admin on Mon Mar 31 23:17:28 GMT 2025
PRIMARY
Related Record Type Details
Structure of DROPROPIZINE HYDROCHLORIDE, (R)-
ENANTIOMER -> RACEMATE
Structure of DROPROPIZINE HYDROCHLORIDE, (S)-
ENANTIOMER -> RACEMATE
Structure of DROPROPIZINE
PARENT -> SALT/SOLVATE
NIH
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