DROPROPIZINE HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H20N2O2.ClH
Molecular Weight	272.771
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

Cl.OCC(O)CN1CCN(CC1)C2=CC=CC=C2

InChI

InChIKey=QBZODDIRPJEEQW-UHFFFAOYSA-N

InChI=1S/C13H20N2O2.ClH/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12;/h1-5,13,16-17H,6-11H2;1H

HIDE SMILES / InChI

Molecular Formula	C13H20N2O2
Molecular Weight	236.3101
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Dropropizine is a cough suppressant. It has peripheral action in non-productive cough. Dropropizine is commercialized in Latin American and African countries.

CNS Activity

Originator

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106	Primary		Approved 8,583	TROFERIT

Doses

Show entries

Dose	Population	Adverse events
90 mg single, oral Studied dose	healthy, ADULT
1 mg/kg 3 times / day multiple, oral Studied dose	unhealthy, CHILD	Disc. AE: Somnolence...

Showing 1 to 2 of 2 entries

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AEs

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AE	Significance	Dose	Population
Somnolence	grade 3, 0.79% Disc. AE	1 mg/kg 3 times / day multiple, oral Studied dose	unhealthy, CHILD

Showing 1 to 1 of 1 entries

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PubMed

Show entries

Title	Date	PubMed
Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae).	2003	13678247
Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.	2003 Dec 25	14643514
Antitussive effect of diltiazem in experimental conditions.	2004	15535110
Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.	2004 Aug	15257075
The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.	2009	19507659

Showing 1 to 5 of 7 entries

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Patents

Sample Use Guides

In Vivo Use Guide

30 mg 6 or 8 hourly

Route of Administration: Oral

In Vitro Use Guide

When the Chinese hamster V79 cells were treated with the highest concentration of Dropropizine (8000 ug/ml), cytostatic effects lasting 24 h were observed