CHLORACYZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H21ClN2OS
Molecular Weight	360.901
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCC(=O)N1C2=CC=CC=C2SC3=CC=C(Cl)C=C13

InChI

InChIKey=ZZKWNLZUYAGVOT-UHFFFAOYSA-N

InChI=1S/C19H21ClN2OS/c1-3-21(4-2)12-11-19(23)22-15-7-5-6-8-17(15)24-18-10-9-14(20)13-16(18)22/h5-10,13H,3-4,11-12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C19H21ClN2OS
Molecular Weight	360.901
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5373324 | https://www.ncbi.nlm.nih.gov/pubmed/1157501 | https://www.ncbi.nlm.nih.gov/pubmed/5701273 | https://www.ncbi.nlm.nih.gov/pubmed/974382 |

Chloracyzine is phenothiazine derivative with vasodilatory activity. Chloracyzine produced a decrease in myocardial oxygen consumption accompanied by a reduction in coronary blood flow preceded by transient coronary dilatation. Chloracyzine produced an insignificant increase in arterial pressure; heart rate increased slightly in the open-chest experiments but not in the isolated heart. It is suggested that reduced oxygen uptake after chloracyzine is realized through improved efficiency in the use of oxygen.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of papaverine, chloracyzine, and bencyclane on local blood flow and oxygen tension in cat brain.	1975	1157501

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:52:59 GMT 2025` Edited by `admin` on `Mon Mar 31 17:52:59 GMT 2025`
Record UNII	TZ913SWN6M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

G-020

Preferred Name

English

CHLORACYZINE

Official Name

English

2-CHLORO-10-(3-DIETHYLAMINOPROPIONYL)PHENOTHIAZINE

Systematic Name

English

CHLORACIZINE [MI]

Common Name

English

chloracyzine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29707