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Details

Stereochemistry ACHIRAL
Molecular Formula C19H21ClN2OS.ClH
Molecular Weight 397.362
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORACYZINE HYDROCHLORIDE

SMILES

Cl.CCN(CC)CCC(=O)N1C2=CC(Cl)=CC=C2SC3=C1C=CC=C3

InChI

InChIKey=QELDTSNVBZMBTQ-UHFFFAOYSA-N
InChI=1S/C19H21ClN2OS.ClH/c1-3-21(4-2)12-11-19(23)22-15-7-5-6-8-17(15)24-18-10-9-14(20)13-16(18)22;/h5-10,13H,3-4,11-12H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula C19H21ClN2OS
Molecular Weight 360.901
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Chloracyzine is phenothiazine derivative with vasodilatory activity. Chloracyzine produced a decrease in myocardial oxygen consumption accompanied by a reduction in coronary blood flow preceded by transient coronary dilatation. Chloracyzine produced an insignificant increase in arterial pressure; heart rate increased slightly in the open-chest experiments but not in the isolated heart. It is suggested that reduced oxygen uptake after chloracyzine is realized through improved efficiency in the use of oxygen.

Originator

Sources: Sbornik Nauch. Rabot. Moskov. Farmatsevt. Inst. (1957), 1, 313-17.

Approval Year

PubMed

PubMed

TitleDatePubMed
Effects of papaverine, chloracyzine, and bencyclane on local blood flow and oxygen tension in cat brain.
1975
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Dec 16 07:23:25 UTC 2023
Edited
by admin
on Sat Dec 16 07:23:25 UTC 2023
Record UNII
3R20PI460D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLORACYZINE HYDROCHLORIDE
Common Name English
CHLORACIZIN HYDROCHLORIDE
Common Name English
PHENOTHIAZINE, 2-CHLORO-10-(N,N-DIETHYL-.BETA.-ALANYL)-, MONOHYDROCHLORIDE
Systematic Name English
CHLORACIZINE HYDROCHLORIDE [MI]
Common Name English
2-CHLORO-10-(3-(DIETHYLAMINO)PROPIONYL)-10H-PHENOTHIAZINIUM CHLORIDE
Systematic Name English
1-PROPANONE, 1-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)-3-(DIETHYLAMINO)-, HYDROCHLORIDE (1:1)
Systematic Name English
10H-PHENOTHIAZINE, 2-CHLORO-10-(3-(DIETHYLAMINO)-1-OXOPROPYL)-, MONOHYDROCHLORIDE
Systematic Name English
CHLORACIZINE HYDROCHLORIDE
MI  
Common Name English
Code System Code Type Description
FDA UNII
3R20PI460D
Created by admin on Sat Dec 16 07:23:25 UTC 2023 , Edited by admin on Sat Dec 16 07:23:25 UTC 2023
PRIMARY
EPA CompTox
DTXSID40909008
Created by admin on Sat Dec 16 07:23:25 UTC 2023 , Edited by admin on Sat Dec 16 07:23:25 UTC 2023
PRIMARY
MERCK INDEX
m3338
Created by admin on Sat Dec 16 07:23:25 UTC 2023 , Edited by admin on Sat Dec 16 07:23:25 UTC 2023
PRIMARY Merck Index
CAS
1045-82-5
Created by admin on Sat Dec 16 07:23:25 UTC 2023 , Edited by admin on Sat Dec 16 07:23:25 UTC 2023
PRIMARY
ECHA (EC/EINECS)
213-877-1
Created by admin on Sat Dec 16 07:23:25 UTC 2023 , Edited by admin on Sat Dec 16 07:23:25 UTC 2023
PRIMARY
PUBCHEM
160559
Created by admin on Sat Dec 16 07:23:25 UTC 2023 , Edited by admin on Sat Dec 16 07:23:25 UTC 2023
PRIMARY
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ACTIVE MOIETY