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Details

Stereochemistry ACHIRAL
Molecular Formula C21H28N2O2.ClH
Molecular Weight 376.92
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DECLOXIZINE HYDROCHLORIDE

SMILES

Cl.OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=DDKYRGRSMTYEPD-UHFFFAOYSA-N
InChI=1S/C21H28N2O2.ClH/c24-16-18-25-17-15-22-11-13-23(14-12-22)21(19-7-3-1-4-8-19)20-9-5-2-6-10-20;/h1-10,21,24H,11-18H2;1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C21H28N2O2
Molecular Weight 340.4592
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Decloxizine (UCB-1402; NSC289116) is a histamine 1 receptor antagonist. Decloxizine is a broncholyticum.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
[Preliminary study of effects of decloxizine on air passage resistance in chronic bronchitis patients].
1968 Jul-Oct
[Protective effect of decloxizine in relation to bronchospasm due to histamine].
1968 Jul-Oct
Bronchodilator action of drug combinations in asthmatic patients: decloxizine, orciprenaline, and ephedrine.
1969 Jun
Effect of decloxizine on histamine aerosol induced bronchoconstriction in the conscious guinea-pig.
1969 Nov
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Intravenous route is possible https://www.ncbi.nlm.nih.gov/pubmed/4904306
Three daily 50 mg doses of decloxizine proved sufficient to prevent asthma attacks and shortness of breath in the patients examined
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:06:34 GMT 2023
Edited
by admin
on Sat Dec 16 10:06:34 GMT 2023
Record UNII
TWC294RL1T
Record Status Validated (UNII)
Record Version
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Name Type Language
DECLOXIZINE HYDROCHLORIDE
WHO-DD  
Common Name English
ETHANOL, 2-(2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)-, HYDROCHLORIDE (1:1)
Systematic Name English
Decloxizine hydrochloride [WHO-DD]
Common Name English
Code System Code Type Description
PUBCHEM
46783864
Created by admin on Sat Dec 16 10:06:34 GMT 2023 , Edited by admin on Sat Dec 16 10:06:34 GMT 2023
PRIMARY
CAS
1263283-80-2
Created by admin on Sat Dec 16 10:06:34 GMT 2023 , Edited by admin on Sat Dec 16 10:06:34 GMT 2023
PRIMARY
FDA UNII
TWC294RL1T
Created by admin on Sat Dec 16 10:06:34 GMT 2023 , Edited by admin on Sat Dec 16 10:06:34 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY