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Details

Stereochemistry ACHIRAL
Molecular Formula C21H28N2O2.ClH
Molecular Weight 376.92
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DECLOXIZINE HYDROCHLORIDE

SMILES

Cl.OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=DDKYRGRSMTYEPD-UHFFFAOYSA-N
InChI=1S/C21H28N2O2.ClH/c24-16-18-25-17-15-22-11-13-23(14-12-22)21(19-7-3-1-4-8-19)20-9-5-2-6-10-20;/h1-10,21,24H,11-18H2;1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C21H28N2O2
Molecular Weight 340.4592
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Decloxizine (UCB-1402; NSC289116) is a histamine 1 receptor antagonist. Decloxizine is a broncholyticum.

CNS Activity

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Patents

06903118
3

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Intravenous route is possible https://www.ncbi.nlm.nih.gov/pubmed/4904306
Three daily 50 mg doses of decloxizine proved sufficient to prevent asthma attacks and shortness of breath in the patients examined
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:06:34 GMT 2023
Edited
by admin
on Sat Dec 16 10:06:34 GMT 2023
Record UNII
TWC294RL1T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DECLOXIZINE HYDROCHLORIDE
WHO-DD  
Common Name English
ETHANOL, 2-(2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)-, HYDROCHLORIDE (1:1)
Systematic Name English
Decloxizine hydrochloride [WHO-DD]
Common Name English
Code System Code Type Description
PUBCHEM
46783864
Created by admin on Sat Dec 16 10:06:34 GMT 2023 , Edited by admin on Sat Dec 16 10:06:34 GMT 2023
PRIMARY
CAS
1263283-80-2
Created by admin on Sat Dec 16 10:06:34 GMT 2023 , Edited by admin on Sat Dec 16 10:06:34 GMT 2023
PRIMARY
FDA UNII
TWC294RL1T
Created by admin on Sat Dec 16 10:06:34 GMT 2023 , Edited by admin on Sat Dec 16 10:06:34 GMT 2023
PRIMARY
Related Record Type Details
Structure of DECLOXIZINE
ACTIVE MOIETY
NIH
NCATS
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