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Details

Stereochemistry RACEMIC
Molecular Formula C3H5O3.Na
Molecular Weight 112.0598
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Sodium lactate

SMILES

[Na+].CC(O)C([O-])=O

InChI

InChIKey=NGSFWBMYFKHRBD-UHFFFAOYSA-M
InChI=1S/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C3H5O3
Molecular Weight 89.07
Charge -1
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.brambleberry.com/sodium-lactate-p5127.aspx | http://www.fbcindustries.com/Sodium_Lactate.aspx

Sodium lactate is primarily indicated as a source of bicarbonate for prevention or control of mild to moderate metabolic acidosis in patients with restricted oral intake whose oxidative processes are not seriously impaired. Sodium Lactate is most commonly associated with an E number of “E325” Sodium Lactate blends are commonly used in meat and poultry products to extend shelf life and increase food safety. They have a broad antimicrobial action and are effective at inhibiting most spoilage and pathogenic bacteria. In addition sodium lactate is used in cosmetics as a humectant, providing moisture.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
SODIUM LACTATE IN PLASTIC CONTAINER

Approved Use

Sodium Lactate Injection, USP 50 mEq (5 mEq/mL), is primarily indicated, after dilution, as a source of bicarbonate for prevention or control of mild to moderate metabolic acidosis in patients with restricted oral intake whose oxidative processes are not seriously impaired. It is not intended nor effective for correcting severe acidotic states which require immediate restoration of plasma bicarbonate levels. Sodium lactate has no advantage over sodium bicarbonate and may be detrimental in the management of lactic acidosis

Launch Date

4.63103984E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
20.2 μg/mL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTATE ION, L- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
2.03 mg/dL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTIC ACID, D- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
53.35 mg × h/dL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTATE ION, L- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
4.44 mg × h/dL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTIC ACID, D- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Lactate- and isoproterenol-induced panic attacks in panic disorder patients and controls.
1988 Feb
Cloning of a lactate dehydrogenase gene from Clostridium acetobutylicum B643 and expression in Escherichia coli.
1990 Dec
Malignant ventricular tachycardia during propafenone treatment in a child with junctional automatic tachycardia: effectiveness of intravenous molar sodium lactate.
1991 May
Physiological and behavioral effects of naloxone and lactate in normal volunteers with relevance to the pathophysiology of panic disorder.
2007 Jan 15
Patents

Sample Use Guides

Sodium Lactate Injection, USP 50 mEq (5 mEq/mL) is administered intravenously only after addition to a larger volume of fluid. The amount of sodium ion and lactate ion to be added to larger volume intravenous fluids should be determined in accordance with the electrolyte requirements of each individual patient. All or part of the content(s) of one (50 mEq in 10 mL) or more vial containers may be added to other intravenous solutions to provide any desired number of milliequivalents of lactate anion (with the same number of milliequivalents of Na+ ). The contents of one container (50 mEq in 10 mL) added to 290 mL of a nonelectrolyte solution or of sterile water for injection will provide 300 mL of an approximately isotonic (1/6 molar) concentration of sodium lactate (1.9%), containing 167 mEq/liter each of Na+ and lactate anion
Route of Administration: Intravenous
10 mM sodium lactate inhibits activated T cell motility
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:01:47 UTC 2023
Edited
by admin
on Fri Dec 15 15:01:47 UTC 2023
Record UNII
TU7HW0W0QT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Sodium lactate
II   INCI   JAN   MI   ORANGE BOOK   USP   VANDF   WHO-DD  
INCI  
Official Name English
SODIUM LACTATE [II]
Common Name English
SODIUM LACTATE [INCI]
Common Name English
INS-325
Code English
SODIUM LACTATE, (±)-
Systematic Name English
COMPOUND SOLUTION OF SODIUM LACTATE
INN  
INN  
Official Name English
SODIUM LACTATE [JAN]
Common Name English
SODIUM LACTATE SOLUTION [FCC]
Common Name English
NATRUM LACTICUM [HPUS]
Common Name English
SODIUM LACTATE [VANDF]
Common Name English
SODIUM LACTATE [USP-RS]
Common Name English
SODIUM LACTATE SOLUTION [EP MONOGRAPH]
Common Name English
INS NO.325
Code English
SODIUM LACTATE SOLUTION
FCC  
Common Name English
compound solution of sodium lactate [INN]
Common Name English
SODIUM LACTATE [USP IMPURITY]
Common Name English
SODIUM LACTATE [ORANGE BOOK]
Common Name English
SODIUM (LACTATE) ANHYDROUS
Common Name English
SODIUM 2-HYDROXYPROPANOATE
Systematic Name English
NSC-31718
Code English
SODIUM DL-LACTATE
Common Name English
PROPANOIC ACID, 2-HYDROXY-, MONOSODIUM SALT
Common Name English
SODIUM LACTATE [MI]
Common Name English
E-325
Code English
NATRUM LACTICUM
HPUS  
Common Name English
Sodium lactate [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29730
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 26.2
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
JECFA EVALUATION INS-325
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
CODEX ALIMENTARIUS (GSFA) INS-325
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
CFR 21 CFR 184.1768
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
Code System Code Type Description
EVMPD
SUB12297MIG
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PRIMARY
CHEBI
75228
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PRIMARY
DRUG CENTRAL
4202
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PRIMARY
PUBCHEM
23666456
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PRIMARY
DRUG BANK
DB09294
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PRIMARY
CAS
72-17-3
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PRIMARY
MERCK INDEX
m10037
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID6052829
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PRIMARY
DAILYMED
TU7HW0W0QT
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY
ChEMBL
CHEMBL1357
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PRIMARY
NCI_THESAURUS
C47726
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PRIMARY
INN
4157
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PRIMARY
SMS_ID
100000090101
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY
FDA UNII
TU7HW0W0QT
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY
EVMPD
SUB15300MIG
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY
RS_ITEM_NUM
1614308
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY
MESH
D019354
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY
RXCUI
56489
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
200-772-0
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY
NSC
31718
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY
EVMPD
SUB121838
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY
WIKIPEDIA
SODIUM LACTATE
Created by admin on Fri Dec 15 15:01:47 UTC 2023 , Edited by admin on Fri Dec 15 15:01:47 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY
ACTIVE MOIETY