U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C3H6O3
Molecular Weight 90.0779
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LACTIC ACID, DL-

SMILES

CC(O)C(O)=O

InChI

InChIKey=JVTAAEKCZFNVCJ-UHFFFAOYSA-N
InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)

HIDE SMILES / InChI

Molecular Formula C3H6O3
Molecular Weight 90.0779
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: Description was created based on several sources, including https://www.brambleberry.com/sodium-lactate-p5127.aspx | http://www.fbcindustries.com/Sodium_Lactate.aspx

Sodium lactate is primarily indicated as a source of bicarbonate for prevention or control of mild to moderate metabolic acidosis in patients with restricted oral intake whose oxidative processes are not seriously impaired. Sodium Lactate is most commonly associated with an E number of “E325” Sodium Lactate blends are commonly used in meat and poultry products to extend shelf life and increase food safety. They have a broad antimicrobial action and are effective at inhibiting most spoilage and pathogenic bacteria. In addition sodium lactate is used in cosmetics as a humectant, providing moisture.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
SODIUM LACTATE IN PLASTIC CONTAINER

Approved Use

Sodium Lactate Injection, USP 50 mEq (5 mEq/mL), is primarily indicated, after dilution, as a source of bicarbonate for prevention or control of mild to moderate metabolic acidosis in patients with restricted oral intake whose oxidative processes are not seriously impaired. It is not intended nor effective for correcting severe acidotic states which require immediate restoration of plasma bicarbonate levels. Sodium lactate has no advantage over sodium bicarbonate and may be detrimental in the management of lactic acidosis

Launch Date

4.63103984E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
20.2 μg/mL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTATE ION, L- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
2.03 mg/dL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTIC ACID, D- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
53.35 mg × h/dL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTATE ION, L- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
4.44 mg × h/dL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTIC ACID, D- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Lactate- and isoproterenol-induced panic attacks in panic disorder patients and controls.
1988 Feb
Cloning of a lactate dehydrogenase gene from Clostridium acetobutylicum B643 and expression in Escherichia coli.
1990 Dec
Malignant ventricular tachycardia during propafenone treatment in a child with junctional automatic tachycardia: effectiveness of intravenous molar sodium lactate.
1991 May
Physiological and behavioral effects of naloxone and lactate in normal volunteers with relevance to the pathophysiology of panic disorder.
2007 Jan 15
Patents

Sample Use Guides

Sodium Lactate Injection, USP 50 mEq (5 mEq/mL) is administered intravenously only after addition to a larger volume of fluid. The amount of sodium ion and lactate ion to be added to larger volume intravenous fluids should be determined in accordance with the electrolyte requirements of each individual patient. All or part of the content(s) of one (50 mEq in 10 mL) or more vial containers may be added to other intravenous solutions to provide any desired number of milliequivalents of lactate anion (with the same number of milliequivalents of Na+ ). The contents of one container (50 mEq in 10 mL) added to 290 mL of a nonelectrolyte solution or of sterile water for injection will provide 300 mL of an approximately isotonic (1/6 molar) concentration of sodium lactate (1.9%), containing 167 mEq/liter each of Na+ and lactate anion
Route of Administration: Intravenous
10 mM sodium lactate inhibits activated T cell motility
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:46:15 UTC 2023
Edited
by admin
on Wed Jul 05 22:46:15 UTC 2023
Record UNII
3B8D35Y7S4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LACTIC ACID, DL-
II  
Common Name English
RACEMIC LACTIC ACID
Common Name English
(±)-LACTIC ACID
Systematic Name English
.ALPHA.-HYDROXYPROPIONIC ACID
Systematic Name English
DL-LACTIC ACID [MI]
Common Name English
LACTIC ACID (+-)
Common Name English
.ALPHA.-HYDROXYPROPANOIC ACID
Systematic Name English
ORDINARY LACTIC ACID
Common Name English
ACIDUM LACTICUM [WHO-IP LATIN]
Common Name English
INS-270
Code English
LACTIC ACID, DL- [II]
Common Name English
DL- Lactic acid [WHO-DD]
Common Name English
LACTICUM ACIDUM [HPUS]
Common Name English
PURAC FCC 88
Code English
LACTICUM ACIDUM
HPUS  
Common Name English
TONSILLOSAN
Common Name English
(±)-2-HYDROXYPROPANOIC ACID
Systematic Name English
E 270
Code English
LUREX
Brand Name English
NSC-367919
Code English
E-270
Code English
INS NO.270
Code English
LACTIC ACID [JAN]
Common Name English
PURAC FCC 80
Code English
DL-LACTIC ACID
MI  
Common Name English
HIPURE 88
Code English
MILK ACID
Brand Name English
LACTIC ACID [WHO-IP]
Common Name English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-270
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
JECFA EVALUATION INS-270
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
CFR 21 CFR 862.1450
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
Code System Code Type Description
NSC
367919
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
RXCUI
1314409
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY RxNorm
JECFA MONOGRAPH
INS-270
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
DAILYMED
3B8D35Y7S4
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
SMS_ID
100000089031
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
LACTIC ACID, DL-
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY Description: A colourless or slightly yellow, clear, syrupy, caustic liquid; odourless or with a slight characteristic odour. Miscibility: Miscible with water, ethanol (~750 g/l) TS, and ether R.Category: Used in the preparation of sodium lactate solution as electrolyte. Storage: Lactic acid should be kept in a tightly closed container.Additional information. Lactic acid as described is not suitable for parenteral administration (haemodialysis). Lactic acid is usuallya racemate (RS), but the (+)-(S)-isomer may predominate; it is hygroscopic. Requirement: Definition- Lactic acid is a mixture of lactic acid, its condensation products, and water, the equilibrium between the components being dependent on the concentration and temperature. Lactic acid contains not less than 88.0% m/mand not more than the equivalent of 92.0% m/mof C3H6O3.
CAS
50-21-5
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
CAS
598-82-3
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
SUPERSEDED
FDA UNII
3B8D35Y7S4
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
ECHA (EC/EINECS)
209-954-4
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
CAS
849585-22-4
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
SUPERSEDED
NCI_THESAURUS
C80130
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
CONCEPT Industrial Aid
EPA CompTox
DTXSID7023192
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
HSDB
800
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
PUBCHEM
612
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
CAS
152-36-3
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
SUPERSEDED
ECHA (EC/EINECS)
200-018-0
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
NON-SPECIFIC STEREOCHEMISTRY
MERCK INDEX
M6654
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY Merck Index
EVMPD
SUB22126
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
CAS
1334714-39-4
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
SUPERSEDED
DRUG BANK
DB04398
Created by admin on Wed Jul 05 22:46:15 UTC 2023 , Edited by admin on Wed Jul 05 22:46:15 UTC 2023
PRIMARY
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