SODIUM CATION

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Na
Molecular Weight	22.9898
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

[Na+]

InChI

InChIKey=FKNQFGJONOIPTF-UHFFFAOYSA-N

InChI=1S/Na/q+1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27904181 | https://www.ncbi.nlm.nih.gov/pubmed/27382594http://www.hmdb.ca/metabolites/HMDB00588
Curator's Comment: description was created based on several sources, including https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018

Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium channel alpha subunit 76 Target ID: CHEMBL2331043 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28416444	Substrate 661
Sodium/potassium-transporting ATPase 39 Target ID: CHEMBL2095186 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23284664	Substrate 661

Conditions

Condition	Modality	Highest Phase	Product
Nail grooves 10 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6eeb7bf1-cfd6-4574-94bb-ff69ec91359f	Primary	Approved 8429	POTASSIUM HYDROXIDE Approved Use Used as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office. Launch Date 2010
Plane warts 10 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27904181	Primary	Phase II 1132	Unknown Approved Use Unknown
Molluscum contagiosum 10 Sources: https://clinicaltrials.gov/ct2/show/NCT01348386	Primary	Phase III 656	Unknown Approved Use Unknown
Genital warts 14 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27382594	Primary	Phase II 1132	Unknown Approved Use Unknown
Hyperkalemia 11 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/011287s023lbl.pdf	Primary	Approved 8429	Kayexalate Approved Use INDICATION AND USAGE Kayexalate is indicated for the treatment of hyperkalemia. Launch Date 1958

PubMed

Title	Date	PubMed
Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism.	1994 Dec 20	7528928
Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts.	1997 Feb	9124401
One-electron reduction of chromium(VI) by alpha-lipoic acid and related hydroxyl radical generation, dG hydroxylation and nuclear transcription factor-kappaB activation.	1997 Feb 15	9028868
Inhibition of HIV-1 infection by zinc group metal compounds.	1999 Sep	10517314
Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes.	1999 Sep-Oct	10559675
Role of aquaporin water channels in pleural fluid dynamics.	2000 Dec	11078688
Different protective roles in vitro of alpha- and beta-domains of growth inhibitory factor (GIF) on neuron injuries caused by oxygen free radicals.	2001 Dec 5	11750760
Cr (VI) increases tyrosine phosphorylation through reactive oxygen species-mediated reactions.	2001 Jun	11678602
In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis.	2001 Mar 1	11182525
NKCC activity restores muscle water during hyperosmotic challenge independent of insulin, ERK, and p38 MAPK.	2003 Mar	12433675
The mineralocorticoid receptor: a journey exploring its diversity and specificity of action.	2005 Sep	15802372
Inherited sodium avid states.	2006 Apr	16580612
Gill membrane remodeling with soft-water acclimation in zebrafish (Danio rerio).	2007 Jun 19	17299134
Tobramycin-induced aquagenic wrinkling of the palms in a patient with cystic fibrosis.	2009 Jul	19438544
Ferritin enhances salsolinol-mediated DNA strand breakage: protection by carnosine and related compounds.	2009 Jul 10	19433265
Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus.	2011 Apr	21219332
Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.	2011 Apr 1	21215309
Water permeability and characterization of aquaporin-11.	2011 May	21251984
Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells.	2012 Jun	22490669

Patents

Sample Use Guides

In Vivo Use Guide

10% Potassium Hydroxide

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 13:20:31 GMT 2023` Edited by `admin` on `Sat Dec 16 13:20:31 GMT 2023`
Record UNII	LYR4M0NH37
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SODIUM CATION

Common Name

English

SODIUM, ION (NA1+)

Common Name

English

SODIUM ION

Common Name

English

Classification Tree Code System Code

WHO-ATC

S01XA03