Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
[Na+]
InChI
InChIKey=FKNQFGJONOIPTF-UHFFFAOYSA-N
InChI=1S/Na/q+1
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/27904181 | https://www.ncbi.nlm.nih.gov/pubmed/27382594http://www.hmdb.ca/metabolites/HMDB00588Curator's Comment: description was created based on several sources, including
https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27904181 | https://www.ncbi.nlm.nih.gov/pubmed/27382594http://www.hmdb.ca/metabolites/HMDB00588
Curator's Comment: description was created based on several sources, including
https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018
Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.
CNS Activity
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2331043 |
|||
Target ID: CHEMBL2095186 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | POTASSIUM HYDROXIDE Approved UseUsed as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office. Launch Date2010 |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Kayexalate Approved UseINDICATION AND USAGE
Kayexalate is indicated for the treatment of hyperkalemia. Launch Date1958 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Copper(II)-human amylin complex protects pancreatic cells from amylin toxicity. | 2013-08-14 |
|
| Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux. | 2013-02 |
|
| Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD). | 2012-09 |
|
| Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. | 2012-06-01 |
|
| Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells. | 2012-06 |
|
| A novel aquaporin 3 in killifish (Fundulus heteroclitus) is not an arsenic channel. | 2012-05 |
|
| Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation. | 2012-04 |
|
| Estrogen prevents increased hepatic aquaporin-9 expression and glycerol uptake during starvation. | 2012-02-01 |
|
| Inhibition of aquaporin-3 water channel in the colon induces diarrhea. | 2012 |
|
| Water permeability and characterization of aquaporin-11. | 2011-05 |
|
| Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase. | 2011-04-01 |
|
| Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus. | 2011-04 |
|
| Endothelins decrease the expression of aquaporins and plasma membrane water permeability in cultured rat astrocytes. | 2011-03 |
|
| Identification and characterization of functional aquaporin water channel protein from alimentary tract of whitefly, Bemisia tabaci. | 2011-03 |
|
| Testosterone modulates pituitary vasotocin receptor expression and adrenal activity in osmotically stressed chicken. | 2011-01 |
|
| Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. | 2010-09-06 |
|
| Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance. | 2010-08-01 |
|
| Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation. | 2010-04-21 |
|
| Evidence for the involvement of aquaporins in sperm motility activation of the teleost gilthead sea bream (Sparus aurata). | 2009-11 |
|
| Expression and functional characterization of four aquaporin water channels from the European eel (Anguilla anguilla). | 2009-09-01 |
|
| Ferritin enhances salsolinol-mediated DNA strand breakage: protection by carnosine and related compounds. | 2009-07-10 |
|
| Tobramycin-induced aquagenic wrinkling of the palms in a patient with cystic fibrosis. | 2009-07 |
|
| A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell. | 2009-02 |
|
| Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions. | 2007-12 |
|
| Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions. | 2007-06-01 |
|
| Two distinct aquaporin-4 cDNAs isolated from medullary cone of quail kidney. | 2007-05 |
|
| The story of the discovery of aquaporins: convergent evolution of ideas--but who got there first? | 2006-10-30 |
|
| Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells. | 2006-02 |
|
| OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. | 2005-02-18 |
|
| Role of reactive oxygen species and Cr(VI) in Ras-mediated signal transduction. | 2004-01 |
|
| Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress. | 2003-12-19 |
|
| Interactions of growth inhibitory factor with hydroxyl and superoxide radicals. | 2003-09 |
|
| Different protective roles in vitro of alpha- and beta-domains of growth inhibitory factor (GIF) on neuron injuries caused by oxygen free radicals. | 2001-12-05 |
|
| Comparison of the effects of O2*-/HO* free radical- and copper ions-oxidized LDL or lipoprotein(a) on the endothelial cell releases of tissue plasminogen activator and plasminogen activator inhibitor-1. | 2001-10-05 |
|
| Cr (VI) increases tyrosine phosphorylation through reactive oxygen species-mediated reactions. | 2001-06 |
|
| In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. | 2001-03-01 |
|
| Effect of beta-blockers on free radical-induced cardiac contractile dysfunction. | 1999-07-27 |
|
| Molecular characterization of a broad selectivity neutral solute channel. | 1998-09-18 |
|
| Reactive oxygen species regulate macrophage scavenger receptor type I, but not type II, in the human monocytic cell line THP-1. | 1998-06 |
|
| Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. | 1998-03-06 |
|
| Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line. | 1997-11 |
|
| Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. | 1997-08-15 |
|
| One-electron reduction of chromium(VI) by alpha-lipoic acid and related hydroxyl radical generation, dG hydroxylation and nuclear transcription factor-kappaB activation. | 1997-02-15 |
|
| Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts. | 1997-02 |
|
| Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. | 1994-12-20 |
|
| Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism. | 1994-12-20 |
|
| Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation. | 1994-09-30 |
|
| A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k. | 1993-03-30 |
|
| Delayed cystitis due to cyclophosphamide. | 1979-01-04 |
|
| Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency. | 1972 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 20:32:26 GMT 2025
by
admin
on
Tue Apr 01 20:32:26 GMT 2025
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| Record UNII |
LYR4M0NH37
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| Record Status |
Validated (UNII)
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| Record Version |
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WHO-ATC |
S01XA03
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NCI_THESAURUS |
C68287
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NDF-RT |
N0000175811
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NCI_THESAURUS |
C597
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LYR4M0NH37
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DTXSID8037671
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LYR4M0NH37
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