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Details

Stereochemistry ACHIRAL
Molecular Formula Na
Molecular Weight 22.9898
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of SODIUM CATION

SMILES

[Na+]

InChI

InChIKey=FKNQFGJONOIPTF-UHFFFAOYSA-N
InChI=1S/Na/q+1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018

Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
POTASSIUM HYDROXIDE

Approved Use

Used as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office.

Launch Date

2010
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Kayexalate

Approved Use

INDICATION AND USAGE Kayexalate is indicated for the treatment of hyperkalemia.

Launch Date

1958
PubMed

PubMed

TitleDatePubMed
Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency.
1972
Age sensitivity to organophosphate-induced delayed polyneuropathy. Biochemical and toxicological studies in developing chicks.
1991 May 15
Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.
1994 Sep 30
Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea.
1997 Aug 15
Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts.
1997 Feb
One-electron reduction of chromium(VI) by alpha-lipoic acid and related hydroxyl radical generation, dG hydroxylation and nuclear transcription factor-kappaB activation.
1997 Feb 15
Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line.
1997 Nov
Reactive oxygen species regulate macrophage scavenger receptor type I, but not type II, in the human monocytic cell line THP-1.
1998 Jun
Molecular characterization of a broad selectivity neutral solute channel.
1998 Sep 18
Cloning and functional expression of rAOP9L a new member of aquaporin family from rat liver.
1999 Feb
Inhibition of HIV-1 infection by zinc group metal compounds.
1999 Sep
Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth.
2002 Feb 15
Synergistic effects of cystic fibrosis transmembrane conductance regulator and aquaporin-9 in the rat epididymis.
2003 May
Interactions of growth inhibitory factor with hydroxyl and superoxide radicals.
2003 Sep
[Water permeability of the OMCD and IMCD cells' basolateral membrane under the conditions of dehydration and dDAVP action].
2004 Jul
Serum electrolyte, serum protein, serum fat and renal responses to a dietary sodium challenge: allostasis and allostatic load.
2004 Jul-Aug
The mineralocorticoid receptor: a journey exploring its diversity and specificity of action.
2005 Sep
Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells.
2006 Feb
The story of the discovery of aquaporins: convergent evolution of ideas--but who got there first?
2006 Oct 30
Two distinct aquaporin-4 cDNAs isolated from medullary cone of quail kidney.
2007 May
Tobramycin-induced aquagenic wrinkling of the palms in a patient with cystic fibrosis.
2009 Jul
Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation.
2010 Apr 21
Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance.
2010 Aug 1
Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia.
2010 Sep 6
Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus.
2011 Apr
Testosterone modulates pituitary vasotocin receptor expression and adrenal activity in osmotically stressed chicken.
2011 Jan
Endothelins decrease the expression of aquaporins and plasma membrane water permeability in cultured rat astrocytes.
2011 Mar
Identification and characterization of functional aquaporin water channel protein from alimentary tract of whitefly, Bemisia tabaci.
2011 Mar
Water permeability and characterization of aquaporin-11.
2011 May
Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation.
2012 Apr
Estrogen prevents increased hepatic aquaporin-9 expression and glycerol uptake during starvation.
2012 Feb 1
Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells.
2012 Jun
A novel aquaporin 3 in killifish (Fundulus heteroclitus) is not an arsenic channel.
2012 May
Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux.
2013 Feb
Patents

Sample Use Guides

10% Potassium Hydroxide
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 13:20:31 GMT 2023
Edited
by admin
on Sat Dec 16 13:20:31 GMT 2023
Record UNII
LYR4M0NH37
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM CATION
Common Name English
SODIUM, ION (NA1+)
Common Name English
SODIUM ION
Common Name English
Classification Tree Code System Code
WHO-ATC S01XA03
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
NCI_THESAURUS C68287
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
NDF-RT N0000175811
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
NCI_THESAURUS C597
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
Code System Code Type Description
FDA UNII
LYR4M0NH37
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY
EPA CompTox
DTXSID8037671
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY
CAS
17341-25-2
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY
PUBCHEM
923
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY
EVMPD
SUB23214
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY
NCI_THESAURUS
C61943
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY
CHEBI
29101
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY
DRUG BANK
DB14516
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY
SMS_ID
100000087148
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY
RXCUI
1364429
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY RxNorm
DAILYMED
LYR4M0NH37
Created by admin on Sat Dec 16 13:20:32 GMT 2023 , Edited by admin on Sat Dec 16 13:20:32 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY