ENOLICAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H12Cl3NO4S
Molecular Weight	432.705
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C(CCS(=O)(=O)C2=C1C=C(Cl)C=C2)C(=O)NC3=CC=C(Cl)C(Cl)=C3

InChI

InChIKey=ANOGOQXCGBMIJV-UHFFFAOYSA-N

InChI=1S/C17H12Cl3NO4S/c18-9-1-4-15-12(7-9)16(22)11(5-6-26(15,24)25)17(23)21-10-2-3-13(19)14(20)8-10/h1-4,7-8,22H,5-6H2,(H,21,23)

HIDE SMILES / InChI

Molecular Formula	C17H12Cl3NO4S
Molecular Weight	432.705
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3503105 | https://www.ncbi.nlm.nih.gov/pubmed/3032204 | https://www.ncbi.nlm.nih.gov/pubmed/6688529 | https://www.ncbi.nlm.nih.gov/pubmed/6441186

Enolicam (CGS 5391B) is a non-steroidal anti-inflammatory drug with combined cyclooxygenase and lipoxygenase inhibitory activity. It is able to trap oxygen radicals. Enolicam was effective in animal models of traumatic shock and osteoarthritis.

Approval Year

PubMed

Title	Date	PubMed
A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically.	1983 Sep	6688529
Inhibitors of lipoxygenase products improve survival in traumatic shock.	1984 Oct	6441186
Diclofenac and enolicam as ocular anti-inflammatory drugs in rabbit corneal wound model.	1986 Spring	3503105
The amplified chemiluminescence test to characterize antirheumatic drugs as oxygen radical scavengers.	1987 Apr 1	3032204
Amiodarone causes acute oxidant lung injury in ventilated and perfused rabbit lungs.	1988 Jul	2459531

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:39:12 GMT 2023` Edited by `admin` on `Fri Dec 15 15:39:12 GMT 2023`
Record UNII	TEA6PI0H6H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ENOLICAM

Official Name

English

enolicam [INN]

Common Name

English

3',4',7-TRICHLORO-2,3-DIHYDRO-5-HYDROXY-1-BENZOTHIEPIN-4-CARBOXANILIDE 1,1-DIOXIDE

Systematic Name

English

1-BENZOTHIEPIN-4-CARBOXAMIDE, 7-CHLORO-N-(3,4-DICHLOROPHENYL)-2,3-DIHYDRO-5-HYDROXY-, 1,1-DIOXIDE

Systematic Name

English

Enolicam [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257