ENOLICAM SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H11Cl3NO4S.Na.H2O
Molecular Weight	472.703
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.[Na+].[O-]C1=C(CCS(=O)(=O)C2=CC=C(Cl)C=C12)C(=O)NC3=CC(Cl)=C(Cl)C=C3

InChI

InChIKey=AVERBMQHYOZACV-UHFFFAOYSA-M

InChI=1S/C17H12Cl3NO4S.Na.H2O/c18-9-1-4-15-12(7-9)16(22)11(5-6-26(15,24)25)17(23)21-10-2-3-13(19)14(20)8-10;;/h1-4,7-8,22H,5-6H2,(H,21,23);;1H2/q;+1;/p-1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C17H12Cl3NO4S
Molecular Weight	432.705
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3503105 | https://www.ncbi.nlm.nih.gov/pubmed/3032204 | https://www.ncbi.nlm.nih.gov/pubmed/6688529 | https://www.ncbi.nlm.nih.gov/pubmed/6441186

Enolicam (CGS 5391B) is a non-steroidal anti-inflammatory drug with combined cyclooxygenase and lipoxygenase inhibitory activity. It is able to trap oxygen radicals. Enolicam was effective in animal models of traumatic shock and osteoarthritis.

Approval Year

PubMed

Title	Date	PubMed
Amiodarone causes acute oxidant lung injury in ventilated and perfused rabbit lungs.	1988-07	2459531
The amplified chemiluminescence test to characterize antirheumatic drugs as oxygen radical scavengers.	1987-04-01	3032204
Diclofenac and enolicam as ocular anti-inflammatory drugs in rabbit corneal wound model.	1986	3503105
Inhibitors of lipoxygenase products improve survival in traumatic shock.	1984-10	6441186
A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically.	1983-09	6688529

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:57:17 GMT 2025` Edited by `admin` on `Mon Mar 31 17:57:17 GMT 2025`
Record UNII	C3QYZ005LS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-BENZOTHIEPIN-4-CARBOXAMIDE, 7-CHLORO-N-(3,4-DICHLOROPHENYL)-2,3-DIHYDRO-5-HYDROXY-, 1,1-DIOXIDE, MONOSODIUM SALT, MONOHYDRATE

Preferred Name

English

ENOLICAM SODIUM

Official Name

English

3',4',7-TRICHLORO-2,3-DIHYDRO-5-HYDROXY-1-BENZOTHIEPIN-4-CARBOXANILIDE 1,1-DIOXIDE, MONOSODIUM SALT, MONOHYDRATE

Systematic Name

English

Enolicam sodium [WHO-DD]

Common Name

English

ENOLICAM SODIUM [USAN]

Common Name

English

1-BENZOTHIEPIN-4-CARBOXAMIDE, 7-CHLORO-N-(3,4-DICHLOROPHENYL)-2,3-DIHYDRO-5-HYDROXY-, 1,1-DIOXIDE, SODIUM SALT, HYDRATE (1:1:1)

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257