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Details

Stereochemistry ACHIRAL
Molecular Formula C19H19NS
Molecular Weight 293.426
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PIMETHIXENE

SMILES

CN1CCC(CC1)=C2C3=C(SC4=C2C=CC=C4)C=CC=C3

InChI

InChIKey=NZLVRVYNQYGMAB-UHFFFAOYSA-N
InChI=1S/C19H19NS/c1-20-12-10-14(11-13-20)19-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)19/h2-9H,10-13H2,1H3

HIDE SMILES / InChI
Molecular Formula C19H19NS
Molecular Weight 293.426
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pimethixene is an antihistamine exerting sedative and antitussive properties. Pimethixene displayed high affinity to serotonin 5-HT2A and 2B, histamine H1 and muscarinic acetylcholine M2 receptors. Oral pimethixene used to calm dry cough and irritation coughs in children.

CNS Activity

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
 10.14 null [pKi]
Antagonist
2778
 9.38 null [pKi]
Antagonist
2778
 10.22 null [pKi]
Antagonist
2778
 10.44 null [pKi]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
CALMIXENE

Approved Use

It is recommended to calm dry cough and irritation coughs in children older than 2 years, especially when they occur in the evening or at night
Primary
Not Provided
504
Unknown

Approved Use

Unknown
Primary
Not Provided
504
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Clinical trials of a new antiallergic substance, 9-(N-methyl-4-piperidylidene)-thioxasthene (BP 400)].
1963 Mar 16
[Clinical experience with the application of pimethixene in the premedication of children].
1967 Sep
[On the pharmacology of 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (WA 335), a histamine and serotonin antagonist (author's transl)].
1975 Nov
[New treatment of hyperkinesis in the child: pimethixene].
1978 Jul 15
LuxR-dependent quorum sensing: computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones.
2010 Aug 1
BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs.
2015 Mar 15
Patents

Patents

US20060120972A1
2
US20100021524A1
2

Sample Use Guides

In Vivo Use Guide
Children from 24 to 30 months: 2 to 3 dosing cups (graduation at 5 ml) distributed over the day, Children from 30 months to 5 years: 3 to 4 dosing cups (graduation at 5 ml) distributed over the day, Children from 5 to 15 years: 5 to 6 dosing cups (graduation at 5 ml) distributed over the day. The strongest dose will be kept for the evening due to the possibility of drowsiness related with this medicine
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:56:15 UTC 2023
Edited
by admin
on Sat Dec 16 17:56:15 UTC 2023
Record UNII
T46J20J26F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PIMETHIXENE
INN   MART.   WHO-DD  
INN  
Official Name English
pimethixene [INN]
Common Name English
CALMIXENE
Brand Name English
PIMETHIXENE [MART.]
Common Name English
Pimethixene [WHO-DD]
Common Name English
1-METHYL-4-(THIOXANTHEN-9-YLIDENE)PIPERIDINE
Systematic Name English
NSC-757828
Code English
BP-400
Code English
PIMETIXENE
Common Name English
BP 400
Code English
Classification Tree Code System Code
WHO-VATC QR06AX23
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
NCI_THESAURUS C29578
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
WHO-ATC R06AX23
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
Code System Code Type Description
CAS
314-03-4
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
FDA UNII
T46J20J26F
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
WIKIPEDIA
PIMETHIXENE
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
DRUG BANK
DB13292
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
EVMPD
SUB09840MIG
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
INN
1739
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
PUBCHEM
4822
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
ChEMBL
CHEMBL152408
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
SMS_ID
100000081932
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
ECHA (EC/EINECS)
206-240-4
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
DRUG CENTRAL
2169
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
EPA CompTox
DTXSID0048476
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
NCI_THESAURUS
C82276
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
RXCUI
33712
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY RxNorm
NSC
757828
Created by admin on Sat Dec 16 17:56:15 UTC 2023 , Edited by admin on Sat Dec 16 17:56:15 UTC 2023
PRIMARY
Related Record Type Details
Structure of PIMETHIXENE MALEATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of PIMETHIXENE
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