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Details

Stereochemistry ACHIRAL
Molecular Formula C19H19NS
Molecular Weight 293.426
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PIMETHIXENE

SMILES

CN1CCC(CC1)=C2C3=C(SC4=C2C=CC=C4)C=CC=C3

InChI

InChIKey=NZLVRVYNQYGMAB-UHFFFAOYSA-N
InChI=1S/C19H19NS/c1-20-12-10-14(11-13-20)19-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)19/h2-9H,10-13H2,1H3

HIDE SMILES / InChI

Molecular Formula C19H19NS
Molecular Weight 293.426
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pimethixene is an antihistamine exerting sedative and antitussive properties. Pimethixene displayed high affinity to serotonin 5-HT2A and 2B, histamine H1 and muscarinic acetylcholine M2 receptors. Oral pimethixene used to calm dry cough and irritation coughs in children.

CNS Activity

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
10.14 null [pKi]
9.38 null [pKi]
10.22 null [pKi]
10.44 null [pKi]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CALMIXENE
Primary
Unknown
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Children from 24 to 30 months: 2 to 3 dosing cups (graduation at 5 ml) distributed over the day, Children from 30 months to 5 years: 3 to 4 dosing cups (graduation at 5 ml) distributed over the day, Children from 5 to 15 years: 5 to 6 dosing cups (graduation at 5 ml) distributed over the day. The strongest dose will be kept for the evening due to the possibility of drowsiness related with this medicine
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
T46J20J26F
Record Status Validated (UNII)
Record Version