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Details

Stereochemistry ACHIRAL
Molecular Formula C19H19NS.C4H4O4
Molecular Weight 409.498
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of PIMETHIXENE MALEATE

SMILES

OC(=O)\C=C/C(O)=O.CN1CCC(CC1)=C2C3=CC=CC=C3SC4=CC=CC=C24

InChI

InChIKey=IPANUAHQWFDVAG-BTJKTKAUSA-N
InChI=1S/C19H19NS.C4H4O4/c1-20-12-10-14(11-13-20)19-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)19;5-3(6)1-2-4(7)8/h2-9H,10-13H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula C19H19NS
Molecular Weight 293.426
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Pimethixene is an antihistamine exerting sedative and antitussive properties. Pimethixene displayed high affinity to serotonin 5-HT2A and 2B, histamine H1 and muscarinic acetylcholine M2 receptors. Oral pimethixene used to calm dry cough and irritation coughs in children.

CNS Activity

Approval Year

TargetsConditions
PubMed

PubMed

TitleDatePubMed
[On the pharmacology of 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (WA 335), a histamine and serotonin antagonist (author's transl)].
1975 Nov
[New treatment of hyperkinesis in the child: pimethixene].
1978 Jul 15
LuxR-dependent quorum sensing: computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones.
2010 Aug 1
BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs.
2015 Mar 15
Patents

Sample Use Guides

In Vivo Use Guide
Children from 24 to 30 months: 2 to 3 dosing cups (graduation at 5 ml) distributed over the day, Children from 30 months to 5 years: 3 to 4 dosing cups (graduation at 5 ml) distributed over the day, Children from 5 to 15 years: 5 to 6 dosing cups (graduation at 5 ml) distributed over the day. The strongest dose will be kept for the evening due to the possibility of drowsiness related with this medicine
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Tue Oct 22 00:18:23 UTC 2019
Edited
by admin
on Tue Oct 22 00:18:23 UTC 2019
Record UNII
U22U244M9X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PIMETHIXENE MALEATE
WHO-DD  
Common Name English
1-METHYL-4-(THIOXANTHEN-9-YLIDENE)PIPERIDINE MALEATE
Systematic Name English
PIMETHIXENE MALEATE [WHO-DD]
Common Name English
PIMETHIXENE MALEATE SALT
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29578
Created by admin on Tue Oct 22 00:18:23 UTC 2019 , Edited by admin on Tue Oct 22 00:18:23 UTC 2019
Code System Code Type Description
ECHA (EC/EINECS)
236-141-1
Created by admin on Tue Oct 22 00:18:23 UTC 2019 , Edited by admin on Tue Oct 22 00:18:23 UTC 2019
PRIMARY
EPA CompTox
13187-06-9
Created by admin on Tue Oct 22 00:18:23 UTC 2019 , Edited by admin on Tue Oct 22 00:18:23 UTC 2019
PRIMARY
CAS
13187-06-9
Created by admin on Tue Oct 22 00:18:23 UTC 2019 , Edited by admin on Tue Oct 22 00:18:23 UTC 2019
PRIMARY
NCI_THESAURUS
C97703
Created by admin on Tue Oct 22 00:18:23 UTC 2019 , Edited by admin on Tue Oct 22 00:18:23 UTC 2019
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY