Approval Year
| Substance Class |
Structurally Diverse
Created
by
admin
on
Edited
Wed Apr 02 20:33:22 GMT 2025
by
admin
on
Wed Apr 02 20:33:22 GMT 2025
|
| Source Materials Class | ORGANISM |
| Source Materials Type | AUTOLOGOUS HUMAN |
| Source Materials State | LIVE GENETICALLY MODIFIED |
| Source Materials Parent | |
| Part | blood |
| Fraction Name | cd4+/cd8+ enriched t cells |
| Record UNII |
T2ZFF62NQ9
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Preferred Name | English | ||
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Official Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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T2ZFF62NQ9
Created by
admin on Wed Apr 02 20:33:22 GMT 2025 , Edited by admin on Wed Apr 02 20:33:22 GMT 2025
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PRIMARY | |||
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C211708
Created by
admin on Wed Apr 02 20:33:22 GMT 2025 , Edited by admin on Wed Apr 02 20:33:22 GMT 2025
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PRIMARY | |||
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12959
Created by
admin on Wed Apr 02 20:33:22 GMT 2025 , Edited by admin on Wed Apr 02 20:33:22 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET->CYTOTOXIC T-CELL |
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TARGET->CYTOTOXIC T-CELL |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
The T lymphocytes (>75%) are positive for the transgenes
(>5% CAR positive), with less than 0.5 % CD19+ cells. The cells produce cytokines (interleukin-6, interleukin-12, and interferon gamma) in co-culture with B lymphocytes
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Agent Modifications
| Modification Process | Modification Role | Modification Type | Amount | Fragment Name | Fragment ID |
|---|---|---|---|---|---|
| LENTIVIRAL TRANSFECTION | TRANSFECTION | GENE MODIFICATION | Elzocabtagene autoleucel vector (anti-CD19 CAR + IL-12-VHL) | JJF47U33ZR | |
| CULTURE | EXPANSION | BIOLOGICAL |
|
HUMAN INTERLEUKIN-2 | FNO32LO217 |
| LENTIVIRAL TRANSFECTION | TRANSFECTION | GENE MODIFICATION | Elzocabtagene autoleucel vector (anti-GCC CAR) | 7N8HP7B54Z | |
| LENTIVIRAL TRANSFECTION | TRANSFECTION | GENE MODIFICATION | Elzocabtagene autoleucel vector (anti-CD19 CAR + IFN-?) | LN3CN73GKK | |
| CULTURE | ACTIVATOR | BIOLOGICAL | ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS | PA28ZKP50M | |
| LENTIVIRAL TRANSFECTION | TRANSFECTION | GENE MODIFICATION | Elzocabtagene autoleucel vector (anti-CD19 CAR + IL-6) | RMG8AY883S |
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| INSERTED GENE EXPRESSION VECTOR | Elzocabtagene autoleucel anti-GCC CAR transgene insert | Q643USN4GW | ||||
| VECTOR EXPRESSED PROTEIN | Elzocabtagene autoleucel expressed anti-GCC CAR | 78UGX6H8Q7 | ||||
| VECTOR EXPRESSED PROTEIN | Elzocabtagene autoleucel expressed interferon gamma (IFN-?) | 9Q2AP23HRD | ||||
| VECTOR EXPRESSED PROTEIN | HUMAN INTERLEUKIN-6 | 4O4QWG0B3C | ||||
| INSERTED GENE EXPRESSION VECTOR | Elzocabtagene autoleucel anti-CD19 CAR + IFN-? transgene insert | 49E9RPQ8S6 | ||||
| INSERTED GENE EXPRESSION VECTOR | Elzocabtagene autoleucel anti-CD19 CAR + IL-6 transgene insert | EBG6T54TTZ | ||||
| VECTOR EXPRESSED PROTEIN | Elzocabtagene autoleucel expressed anti-CD19 CAR | 6UR5HYQ28B | ||||
| VECTOR EXPRESSED PROTEIN | Elzocabtagene autoleucel expressed IL-12-VHL preprotein | FHY3SU39ZU | ||||
| INSERTED GENE EXPRESSION VECTOR | Elzocabtagene autoleucel anti-CD19 CAR + IL-12-VHL transgene insert | UC3TL3H2HQ |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| ANTIGEN LOW EXPRESSION | BIOLOGICAL |
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