BROMODIPHENHYDRAMINE

US Previously Marketed

First approved in 1951

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H20BrNO
Molecular Weight	334.251
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(Br)C=C2

InChI

InChIKey=NUNIWXHYABYXKF-UHFFFAOYSA-N

InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C17H20BrNO
Molecular Weight	334.251
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14377226 | https://www.ncbi.nlm.nih.gov/pubmed/22876948

Bromodiphenhydramine also known as bromazine, is an antihistamine and anticholinergic agent, which was used to under brand name ambordyl. Ambordyfor was indicated for the treatment of allergic symptoms, but that usage, was discontinued. It was shown, that bromodiphenhydramine competed with free histamine for binding at HA-receptor sites and lead to a reduction of the negative symptoms brought on by histamine HA-receptor binding.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 312 Target ID: CHEMBL231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22876948	Antagonist 2737

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergy 42 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14377226	Primary		Approved 8307	AMBODRYL Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY34571	https://www.001chemical.com/chem/118-23-0
001 Chemical	DY34576	https://www.001chemical.com/chem/118081-34-8
ABI Chem	AC1L1DOW
Ambinter	Amb22500288	http://www.ambinter.com/reference/22500288
Angel Pharmatech	AG-10534	http://www.angelpharmatech.com/118-23-0.html
BLD Pharm	BD142761	http://www.bldpharm.com/products/118-23-0.html
BOC Sciences	118-23-0
BOC Sciences	1808-12-4
ChemTik	CTK8G6492
Chemieliva Pharmaceutical Co., Ltd	PBCM0120578
Compound Cloud	15736
Compound Cloud	2444
Hangzhou Yuhao Chemical Technology	RT3395
HongKong Chemhere	SCA38732
Molcore	MC34571	https://www.molcore.com/product/118-23-0
Molcore	MC34576	https://www.molcore.com/product/118081-34-8
MuseChem	M068119
NovoSeek	2444
PI Chemicals	PI-35967
Sigma Aldrich	1077005
Sigma Aldrich	1077005\|USP
Sigma Aldrich	62881
Sigma Aldrich	62881\|SIAL
Sigma Aldrich	PHR1861
Smolecule	S569621	https://www.smolecule.com/products/s569621
THE BioTek	bt-363827	https://www.thebiotek.com/product/others/bt-363827
Toronto Research Chemicals	B678525
ZINC	ZINC000000000095	http://zinc15.docking.org/substances/ZINC000000000095
ZINC	ZINC000001668588	http://zinc15.docking.org/substances/ZINC000001668588
eMolecules	42851214
eMolecules	49258329
eNovation Chemicals	K50523	https://www.enovationchem.com/ProductDetails.asp?ProductID=K50523
eNovation Chemicals	Y1012711	https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1012711

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sun Dec 18 19:55:30 UTC 2022` Edited by `admin` on `Sun Dec 18 19:55:30 UTC 2022`
Record UNII	T032BI7727
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BROMODIPHENHYDRAMINE

Common Name

English

NEO-BENADRYL

Common Name

English

BROMODIPHENHYDRAMINE [MI]

Common Name

English

DESEROL

Common Name

English

HISTABROMAMINE

Common Name

English

BROMODIPHENHYDRAMINE, (±)-

Common Name

English

DIPHENHYDRAMINE IMPURITY C

Common Name

English

Bromazine [WHO-DD]

Common Name

English

4-BROMODIPHEN HYDRAMINE [USP IMPURITY]

Common Name

English

ETHANAMINE, 2-((4-BROMOPHENYL)PHENYLMETHOXY)-N,N-DIMETHYL-

Systematic Name

English

DIMENHYDRINATE IMPURITY H [EP IMPURITY]

Common Name

English

(±)-BROMODIPHENHYDRAMINE

Common Name

English

DIPHENHYDRAMINE HYDROCHLORIDE IMPURITY C [EP IMPURITY]

Common Name

English

BROMAZINE

Official Name

English

DIMENHYDRINATE IMPURITY H

Common Name

English

bromazine [INN]

Common Name

English

BROMODIPHENHYDRAMINE [VANDF]

Common Name

English

Classification Tree Code System Code

WHO-VATC

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