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Details

Stereochemistry RACEMIC
Molecular Formula C17H20BrNO
Molecular Weight 334.251
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BROMODIPHENHYDRAMINE

SMILES

CN(C)CCOC(c1ccccc1)c2ccc(cc2)Br

InChI

InChIKey=NUNIWXHYABYXKF-UHFFFAOYSA-N
InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C17H20BrNO
Molecular Weight 334.251
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Bromodiphenhydramine also known as bromazine, is an antihistamine and anticholinergic agent, which was used to under brand name ambordyl. Ambordyfor was indicated for the treatment of allergic symptoms, but that usage, was discontinued. It was shown, that bromodiphenhydramine competed with free histamine for binding at HA-receptor sites and lead to a reduction of the negative symptoms brought on by histamine HA-receptor binding.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
AMBODRYL

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms.
1955 May-Jun
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment:: The antihistamine compound promethazine (Pz) showed significant antibacterial action when tested against 124 strains of aerobic and 13 strains of anaerobic bacteria belonging to both Gram positive and Gram negative genera. Six Pz-sensitive strains were found to be simultaneously sensitive to similar non-conventional antimicrobics, e.g., methdilazine, bromodiphenhydramine. A high degree of synergism was observed in vitro when Pz was used in combination with methdilazine and bromodiphenhydramine.
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 07:05:28 UTC 2021
Edited
by admin
on Sat Jun 26 07:05:28 UTC 2021
Record UNII
T032BI7727
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BROMODIPHENHYDRAMINE
MI   VANDF  
Common Name English
DIPHENHYDRAMINE HYDROCHLORIDE IMPURITY C [EP]
Common Name English
NEO-BENADRYL
Common Name English
BROMODIPHENHYDRAMINE [MI]
Common Name English
DESEROL
Common Name English
HISTABROMAMINE
Common Name English
BROMODIPHENHYDRAMINE, (+/-)-
Common Name English
DIPHENHYDRAMINE HYDROCHLORIDE SPECIFIED IMPURITY C [EP]
Common Name English
DIPHENHYDRAMINE IMPURITY C
Common Name English
BROMAZINE [WHO-DD]
Common Name English
4-BROMODIPHEN HYDRAMINE [USP]
Common Name English
ETHANAMINE, 2-((4-BROMOPHENYL)PHENYLMETHOXY)-N,N-DIMETHYL-
Systematic Name English
(+/-)-BROMODIPHENHYDRAMINE
Common Name English
BROMAZINE
INN   WHO-DD  
INN  
Official Name English
DIMENHYDRINATE IMPURITY H [EP]
Common Name English
DIMENHYDRINATE IMPURITY H
EP  
Common Name English
BROMAZINE [INN]
Common Name English
BROMODIPHENHYDRAMINE [VANDF]
Common Name English
Classification Tree Code System Code
WHO-VATC QR06AA01
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
NCI_THESAURUS C29578
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
WHO-ATC R06AA01
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
Code System Code Type Description
DRUG BANK
DB01237
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
EVMPD
SUB05908MIG
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
IUPHAR
7132
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
ChEMBL
CHEMBL1201245
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
EPA CompTox
118-23-0
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
DRUG CENTRAL
404
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
NCI_THESAURUS
C61654
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
FDA UNII
T032BI7727
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
RXCUI
19759
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY RxNorm
INN
336
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
PUBCHEM
2444
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
MESH
C011410
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
ECHA (EC/EINECS)
204-238-8
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
MERCK INDEX
M2698
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY Merck Index
WIKIPEDIA
BROMAZINE
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
CAS
118-23-0
Created by admin on Sat Jun 26 07:05:28 UTC 2021 , Edited by admin on Sat Jun 26 07:05:28 UTC 2021
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
TARGET -> INHIBITOR
ENANTIOMER -> RACEMATE
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
ACTIVE MOIETY