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Details

Stereochemistry ABSOLUTE
Molecular Formula C30H34ClN7O10S2
Molecular Weight 752.215
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of CEFIDEROCOL

SMILES

[H][C@]12SCC(C[N+]4(CCNC(=O)C3=C(Cl)C(O)=C(O)C=C3)CCCC4)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC(C)(C)C(O)=O)\C5=CSC(N)=N5)C([O-])=O

InChI

InChIKey=DBPPRLRVDVJOCL-FQRUVTKNSA-N
InChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1

HIDE SMILES / InChI

Molecular Formula C30H34ClN7O10S2
Molecular Weight 752.215
Charge 0
Count
Stereochemistry EPIMERIC
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 1
Optical Activity UNSPECIFIED

Approval Year

Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
138 mg/L
2 g 3 times / day multiple, intravenous
dose: 2 g
route of administration: Intravenous
experiment type: MULTIPLE
co-administered:
CEFIDEROCOL unknown
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
89.7 mg/L
2 g single, intravenous
dose: 2 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
CEFIDEROCOL unknown
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1184 mg × h/L
2 g 3 times / day multiple, intravenous
dose: 2 g
route of administration: Intravenous
experiment type: MULTIPLE
co-administered:
CEFIDEROCOL unknown
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
386 mg × h/mL
2 g single, intravenous
dose: 2 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
CEFIDEROCOL unknown
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Disc. AE: Diarrhea, Drug hypersensitivity...
Other AEs: Diarrhea, Infusion site reactions...
AEs leading to
discontinuation/dose reduction:
Diarrhea (0.3%)
Drug hypersensitivity (0.3%)
Hepatic enzymes increased (0.3%)
Death (grade 5, 0.3%)
Other AEs:
Diarrhea (4%)
Infusion site reactions (4%)
Constipation (3%)
Rash (3%)
Candidiasis (2%)
Cough (2%)
Elevated liver enzymes (2%)
Headache (2%)
Hypokalemia (2%)
Nausea (2%)
Vomiting (2%)
Thrombocytosis (<2%)
Congestive heart failure (<2%)
Bradycardia (<2%)
Atrial fibrillation (<2%)
Abdominal pain (<2%)
Dry mouth (<2%)
Stomatitis (<2%)
Pyrexia (<2%)
Peripheral edema (<2%)
Cholelithiasis (<2%)
Cholecystitis (<2%)
Gallbladder pain (<2%)
Drug hypersensitivity (<2%)
Clostridium difficile infection (<2%)
Prothrombin time prolonged (<2%)
Red blood cells urine positive (<2%)
Creatine phosphokinase increased (<2%)
Decreased appetite (<2%)
Hypocalcemia (<2%)
Fluid overload (<2%)
Dysgeusia (<2%)
Seizure (<2%)
Dyspnea (<2%)
Pleural effusion (<2%)
Pruritis (<2%)
Insomnia (<2%)
Restlessness (<2%)
Sources:
1 g 1 times / day single, intravenous
Dose: 1 g, 1 times / day
Route: intravenous
Route: single
Dose: 1 g, 1 times / day
Sources:
unhealthy, mean age 60.1 years
n = 8
Health Status: unhealthy
Condition: Gram-Negative Bacterial Infections
Age Group: mean age 60.1 years
Sex: M+F
Population Size: 8
Sources:
Disc. AE: Urticaria...
AEs leading to
discontinuation/dose reduction:
Urticaria (12.5%)
Sources:
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Disc. AE: Death, Elevated liver enzymes...
Other AEs: Elevated liver enzymes, Hypokalemia...
AEs leading to
discontinuation/dose reduction:
Death (grade 5, 26.4%)
Elevated liver enzymes
Other AEs:
Elevated liver enzymes (16%)
Hypokalemia (11%)
Diarrhea (9%)
Hypomagnesemia (5%)
Atrial fibrillation (5%)
Thrombocytopenia (<4%)
Thrombocytosis (<4%)
Myocardial infarction (<4%)
Atrial flutter (<4%)
Nausea (<4%)
Vomiting (<4%)
Abdominal pain (<4%)
Cholecystitis (<4%)
Cholestasis (<4%)
Clostridium difficile infection (<4%)
Oral candidiasis (<4%)
Prothrombin time prolonged (<4%)
Activated partial thromboplastin time (<4%)
Hypocalcemia (<4%)
Hyperkalemia (<4%)
Seizure (<4%)
Acute interstitial nephritis (<4%)
Cough (<4%)
Rash (<4%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Diarrhea 0.3%
Disc. AE
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Drug hypersensitivity 0.3%
Disc. AE
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Hepatic enzymes increased 0.3%
Disc. AE
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Candidiasis 2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Cough 2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Elevated liver enzymes 2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Headache 2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Hypokalemia 2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Nausea 2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Vomiting 2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Constipation 3%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Rash 3%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Diarrhea 4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Infusion site reactions 4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Abdominal pain <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Atrial fibrillation <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Bradycardia <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Cholecystitis <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Cholelithiasis <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Clostridium difficile infection <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Congestive heart failure <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Creatine phosphokinase increased <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Decreased appetite <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Drug hypersensitivity <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Dry mouth <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Dysgeusia <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Dyspnea <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Fluid overload <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Gallbladder pain <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Hypocalcemia <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Insomnia <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Peripheral edema <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Pleural effusion <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Prothrombin time prolonged <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Pruritis <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Pyrexia <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Red blood cells urine positive <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Restlessness <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Seizure <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Stomatitis <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Thrombocytosis <2%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Death grade 5, 0.3%
Disc. AE
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 18 to 93 years
n = 300
Health Status: unhealthy
Condition: Complicated Urinary Tract Infections
Age Group: 18 to 93 years
Sex: M+F
Population Size: 300
Sources:
Urticaria 12.5%
Disc. AE
1 g 1 times / day single, intravenous
Dose: 1 g, 1 times / day
Route: intravenous
Route: single
Dose: 1 g, 1 times / day
Sources:
unhealthy, mean age 60.1 years
n = 8
Health Status: unhealthy
Condition: Gram-Negative Bacterial Infections
Age Group: mean age 60.1 years
Sex: M+F
Population Size: 8
Sources:
Hypokalemia 11%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Elevated liver enzymes 16%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Atrial fibrillation 5%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Hypomagnesemia 5%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Diarrhea 9%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Abdominal pain <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Activated partial thromboplastin time <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Acute interstitial nephritis <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Atrial flutter <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Cholecystitis <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Cholestasis <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Clostridium difficile infection <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Cough <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Hyperkalemia <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Hypocalcemia <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Myocardial infarction <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Nausea <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Oral candidiasis <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Prothrombin time prolonged <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Rash <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Seizure <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Thrombocytopenia <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Thrombocytosis <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Vomiting <4%
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Elevated liver enzymes Disc. AE
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
Death grade 5, 26.4%
Disc. AE
2 g 3 times / day multiple, intravenous
Recommended
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, median age - 67 years
n = 148
Health Status: unhealthy
Condition: Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
Age Group: median age - 67 years
Sex: M+F
Population Size: 148
Sources:
OverviewDrug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
no
no
no
no
no
no
no
no
no
no
no
no
no
no
no
no
yes
no (co-administration study)
Comment: The results from a clinical drug-drug interaction study indicate that cefiderocol had no clinically meaningful effects on the PK of furosemide (substrate for OAT1 and OAT3), metformin (for OCT1, OCT2, and MATE2- K), and rosuvastatin (for OATP1B3).
Page: 64.0
yes
no (co-administration study)
Comment: The results from a clinical drug-drug interaction study indicate that cefiderocol had no clinically meaningful effects on the PK of furosemide (substrate for OAT1 and OAT3), metformin (for OCT1, OCT2, and MATE2- K), and rosuvastatin (for OATP1B3).
Page: 64.0
yes
no (co-administration study)
Comment: The results from a clinical drug-drug interaction study indicate that cefiderocol had no clinically meaningful effects on the PK of furosemide (substrate for OAT1 and OAT3), metformin (for OCT1, OCT2, and MATE2- K), and rosuvastatin (for OATP1B3).
Page: 64.0
yes
no (co-administration study)
Comment: The results from a clinical drug-drug interaction study indicate that cefiderocol had no clinically meaningful effects on the PK of furosemide (substrate for OAT1 and OAT3), metformin (for OCT1, OCT2, and MATE2- K), and rosuvastatin (for OATP1B3).
Page: 64.0
yes
no (co-administration study)
Comment: The results from a clinical drug-drug interaction study indicate that cefiderocol had no clinically meaningful effects on the PK of furosemide (substrate for OAT1 and OAT3), metformin (for OCT1, OCT2, and MATE2- K), and rosuvastatin (for OATP1B3).
Page: 64.0
yes
no (co-administration study)
Comment: The results from a clinical drug-drug interaction study indicate that cefiderocol had no clinically meaningful effects on the PK of furosemide (substrate for OAT1 and OAT3), metformin (for OCT1, OCT2, and MATE2- K), and rosuvastatin (for OATP1B3).
Page: 64.0
Drug as victimTox targets

Tox targets

Substance Class Chemical
Created
by admin
on Sat Dec 16 10:36:28 GMT 2023
Edited
by admin
on Sat Dec 16 10:36:28 GMT 2023
Record UNII
SZ34OMG6E8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CEFIDEROCOL
INN   WHO-DD  
INN  
Official Name English
(6R,7R)-7-[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido]-3-({1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidin-1-ium-1-yl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Systematic Name English
CEFIDEROCOL [MI]
Common Name English
S-649266
Code English
PYRROLIDINIUM, 1-(((6R,7R)-7-(((2Z)-2-(2-AMINO-4-THIAZOLYL)-2-((1-CARBOXY-1-METHYLETHOXY)IMINO)ACETYL)AMINO)-2-CARBOXY-8-OXO-5-THIA-1-AZABICYCLO(4.2.0)OCT-2-EN-3-YL)METHYL)-1-(2-((2-CHLORO-3,4-DIHYDROXYBENZOYL)AMINO)ETHYL)-, INNER SALT
Systematic Name English
GSK2696266
Code English
CEFIDEROCOL [USAN]
Common Name English
Cefiderocol [WHO-DD]
Common Name English
cefiderocol [INN]
Common Name English
Classification Tree Code System Code
LIVERTOX NBK548666
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
LIVERTOX NBK547862
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
Code System Code Type Description
DRUG CENTRAL
5352
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
MERCK INDEX
m12179
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
RXCUI
2265702
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
NCI_THESAURUS
C169831
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
DAILYMED
SZ34OMG6E8
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
WIKIPEDIA
Cefiderocol
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
INN
10234
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
DRUG BANK
DB14879
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
FDA UNII
SZ34OMG6E8
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
CHEBI
140376
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
LACTMED
Cefiderocol
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
SMS_ID
100000175826
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID40109805
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
CAS
1225208-94-5
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
USAN
EF-99
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
PUBCHEM
77843966
Created by admin on Sat Dec 16 10:36:28 GMT 2023 , Edited by admin on Sat Dec 16 10:36:28 GMT 2023
PRIMARY
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BINDER->LIGAND
Primarily to albumin
BINDING
TARGET ORGANISM->INHIBITOR
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TARGET ORGANISM->INHIBITOR
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ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC