NADOXOLOL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H16N2O3
Molecular Weight	260.2884
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of NADOXOLOL

Structure Search

SMILES

ONC(=N)CC(O)COC1=CC=CC2=C1C=CC=C2

InChI

InChIKey=UPZVYDSBLFNMLK-UHFFFAOYSA-N

InChI=1S/C14H16N2O3/c15-14(16-18)8-11(17)9-19-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,17-18H,8-9H2,(H2,15,16)

HIDE SMILES / InChI

Molecular Formula	C14H16N2O3
Molecular Weight	260.2884
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12818235 | https://www.ncbi.nlm.nih.gov/pubmed/957857

Nadoxolol is a beta-adrenergic blocking agent and an antihypertensive drug.

Approval Year

PubMed

PubMed

Title	Date	PubMed
[Clinical study of a new anti-arrhythmia agent: nadoxolol].	1976 Apr	957857
Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of beta-adrenergic receptor blockers.	2003 Jun	12818235

Patents

Patents

Sample Use Guides

In Vivo Use Guide

LD50 in mice (mg/kg): 180 i.v.; 1000 orally

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:55:45 GMT 2023` Edited by `admin` on `Fri Dec 15 15:55:45 GMT 2023`
Record UNII	SK43HU1689
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NADOXOLOL

Official Name

English

nadoxolol [INN]

Common Name

English

BUTANIMIDAMIDE, N,3-DIHYDROXY-4-(1-NAPHTHALENYLOXY)-

Systematic Name

English

LL 1530

Code

English

NADOXOLOL [MI]

Common Name

English

Nadoxolol [WHO-DD]

Common Name

English

N,3-DIHYDROXY-4-(1-NAPHTHALENYLOXY)BUTANIMIDAMIDE

Systematic Name

English

3-HYDROXY-4-(1-NAPHTHYLOXY)BUTYRAMIDOXIME

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

Code System Code Type Description

DRUG CENTRAL

1866

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

PRIMARY

FDA UNII

SK43HU1689

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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WIKIPEDIA

Nadoxolol

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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EVMPD

SUB09112MIG

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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MERCK INDEX

m1212

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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Merck Index

MESH

C006154

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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RXCUI

31462

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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RxNorm

ChEMBL

CHEMBL357513

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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EPA CompTox

DTXSID90968903

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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INN

3322

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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SMS_ID

100000084409

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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CAS

54063-51-3

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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PUBCHEM

37333

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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NCI_THESAURUS

C90798

Created by admin on Fri Dec 15 15:55:45 GMT 2023 , Edited by admin on Fri Dec 15 15:55:45 GMT 2023

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SALT/SOLVATE -> PARENT

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					SK43HU1689

NADOXOLOL

ACTIVE MOIETY