NADOXOLOL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H16N2O3.ClH
Molecular Weight	296.749
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.ONC(=N)CC(O)COC1=CC=CC2=C1C=CC=C2

InChI

InChIKey=QMIHLTWUCXXBQQ-UHFFFAOYSA-N

InChI=1S/C14H16N2O3.ClH/c15-14(16-18)8-11(17)9-19-13-7-3-5-10-4-1-2-6-12(10)13;/h1-7,11,17-18H,8-9H2,(H2,15,16);1H

HIDE SMILES / InChI

Molecular Formula	C14H16N2O3
Molecular Weight	260.2884
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12818235 | https://www.ncbi.nlm.nih.gov/pubmed/957857

Nadoxolol is a beta-adrenergic blocking agent and an antihypertensive drug.

Approval Year

PubMed

Title	Date	PubMed
[Clinical study of a new anti-arrhythmia agent: nadoxolol].	1976 Apr	957857
[Acute nadoxolol poisoning. A multicentric study of 35 cases].	1982 May	7135390
Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of beta-adrenergic receptor blockers.	2003 Jun	12818235

Patents

Sample Use Guides

In Vivo Use Guide

LD50 in mice (mg/kg): 180 i.v.; 1000 orally

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 20:41:09 GMT 2023` Edited by `admin` on `Fri Dec 15 20:41:09 GMT 2023`
Record UNII	RZ9G589EN2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NADOXOLOL HYDROCHLORIDE

Common Name

English

NADOXOLOL HYDROCHLORIDE [MI]

Common Name

English

Nadoxolol hydrochloride [WHO-DD]

Common Name

English

BRADYL

Brand Name

English

LL-1530

Code

English

NADOXOLOL HYDROCHLORIDE [MART.]

Common Name

English

BUTANIMIDAMIDE, N,3-DIHYDROXY-4-(1-NAPHTHALENYLOXY)-, HYDROCHLORIDE (1:1)

Systematic Name

English

Code System Code Type Description

CAS

35991-93-6