NEUROPILIN-1

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:20:52 GMT 2025` Edited by `admin` on `Tue Apr 01 23:20:52 GMT 2025`
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	SG52LRE3BJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NEUROPILIN-1

Common Name

English

NRP1

Preferred Name

English

VASCULAR ENDOTHELIAL CELL GROWTH FACTOR 165 RECEPTOR

Common Name

English

CD_ANTIGEN: CD304

Common Name

English

VEGF165R

Code

English

Code System Code Type Description

FDA UNII

SG52LRE3BJ

Created by admin on Tue Apr 01 23:20:52 GMT 2025 , Edited by admin on Tue Apr 01 23:20:52 GMT 2025

PRIMARY

UNIPROT

O14786

Created by admin on Tue Apr 01 23:20:52 GMT 2025 , Edited by admin on Tue Apr 01 23:20:52 GMT 2025

PRIMARY

From	To
1_6	1_33
1_61	1_83
1_126	1_152
1_185	1_207
1_254	1_403
1_410	1_562
2_6	2_33
2_61	2_83
2_126	2_152
2_185	2_207
2_254	2_403
2_410	2_562

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_129
N	1_240
N	1_279
N	1_501
N	1_821
N	2_129
N	2_240
N	2_279
N	2_501
N	2_821
O	1_591
O	2_591

Related Record Type Details


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Amount:


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VESENCUMAB

INHIBITOR -> TARGET


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IRGD

ACTIVATOR -> TARGET

Comments:

Upon ?V binding, a protease cleavage event is activated, revealing the c-terminal CendR motif (R/KXXR/K). The CendR motif is now able to bind to neuropilin-1, activating an endocytotic/exocytotic transport pathway

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_873] [2_873]	SITE_SPECIFIC			DEXFOSFOSERINE	VI4F0K069V
METAL_BINDING	[1_174] [1_188] [1_229] [2_174] [2_188] [2_229]	SITE_SPECIFIC			CALCIUM CATION	2M83C4R6ZB

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL