NEUROPILIN-1

Approval Year

Substance Class	Protein
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	SG52LRE3BJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NEUROPILIN-1

Common Name

English

VASCULAR ENDOTHELIAL CELL GROWTH FACTOR 165 RECEPTOR

Common Name

English

CD_ANTIGEN: CD304

Common Name

English

VEGF165R

Code

English

NRP1

Code

English

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Code System

Code

Type

Description

FDA UNII

SG52LRE3BJ

PRIMARY

UNIPROT

O14786

PRIMARY

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Subunit 0

Subunit 1

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From	To
1_6	1_33
1_61	1_83
1_126	1_152
1_185	1_207
1_254	1_403

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Glycosylation Type

HUMAN

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Glycosylation Link Type	Site
N	1_129
N	1_240
N	1_279
N	1_501
N	1_821

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Related Record

Type

Details


					7PF4546T2P

Certepetide

ACTIVATOR -> TARGET

Amount:


					7SF22186WT

VESENCUMAB

INHIBITOR -> TARGET


					Z8MXU5GH4Q

IRGD

ACTIVATOR -> TARGET

Comments:

Upon αV binding, a protease cleavage event is activated, revealing the c-terminal CendR motif (R/KXXR/K). The CendR motif is now able to bind to neuropilin-1, activating an endocytotic/exocytotic transport pathway

Amount:

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 202000 Da (average)

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