IRGD

Investigational

Approval Year

Substance Class	Protein
Protein Type	PEPTIDE
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	Z8MXU5GH4Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IRGD

Common Name

English

L-CYSTEINE, L-CYSTEINYL-L-ARGINYLGLYCYL-L-.ALPHA.-ASPARTYL-L-LYSYLGLYCYL-L-PROLYL-L-.ALPHA.-ASPARTYL-, CYCLIC (1->9)-DISULFIDE

Common Name

English

INTERNALIZED-ARGINYLGLYCYLASPARTIC ACID CYCLIC PEPTIDE

Common Name

English

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Classification Tree

Code System

Code

Designated

FDA ORPHAN DRUG

669518

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Code System

Code

Type

Description

NCI_THESAURUS

C103858

PRIMARY

CAS

1392278-76-0

PRIMARY

PUBCHEM

134611625

PRIMARY

FDA UNII

Z8MXU5GH4Q

PRIMARY

WIKIPEDIA

iRGD

PRIMARY

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Subunit 0

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From	To
1_1	1_9

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Related Record

Type

Details


					U3G09287OR

INTEGRIN ALPHA-V/BETA-5

TARGET->LIGAND

Amount:


					7PF4546T2P

Certepetide

DEGRADENT -> PARENT

Amount:


					1INU2W9JZP

INTEGRIN ALPHA-V/BETA-3

TARGET->LIGAND

Amount:


					SG52LRE3BJ

NEUROPILIN-1

TARGET -> ACTIVATOR

Comments:

Upon αV binding, a protease cleavage event is activated, revealing the c-terminal CendR motif (R/KXXR/K). The CendR motif is now able to bind to neuropilin-1, activating an endocytotic/exocytotic transport pathway

Amount:

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Related Record

Type

Details


					Z8MXU5GH4Q

IRGD

ACTIVE MOIETY

Amount:

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C35H59N13O14S2
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 948 Da (average)

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