IRGD

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 15:13:01 GMT 2025` Edited by `admin` on `Wed Apr 02 15:13:01 GMT 2025`
Protein Type	PEPTIDE
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	Z8MXU5GH4Q
Record Status	`FAILED`
Record Version

Download

Name

Type

Language

IRGD

Common Name

English

INTERNALIZED-ARGINYLGLYCYLASPARTIC ACID CYCLIC PEPTIDE

Preferred Name

English

L-CYSTEINE, L-CYSTEINYL-L-ARGINYLGLYCYL-L-.ALPHA.-ASPARTYL-L-LYSYLGLYCYL-L-PROLYL-L-.ALPHA.-ASPARTYL-, CYCLIC (1->9)-DISULFIDE

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

669518

Created by admin on Wed Apr 02 15:13:01 GMT 2025 , Edited by admin on Wed Apr 02 15:13:01 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C103858

Created by admin on Wed Apr 02 15:13:01 GMT 2025 , Edited by admin on Wed Apr 02 15:13:01 GMT 2025

PRIMARY

CAS

1392278-76-0

Created by admin on Wed Apr 02 15:13:01 GMT 2025 , Edited by admin on Wed Apr 02 15:13:01 GMT 2025

PRIMARY

PUBCHEM

134611625

Created by admin on Wed Apr 02 15:13:01 GMT 2025 , Edited by admin on Wed Apr 02 15:13:01 GMT 2025

PRIMARY

FDA UNII

Z8MXU5GH4Q

Created by admin on Wed Apr 02 15:13:01 GMT 2025 , Edited by admin on Wed Apr 02 15:13:01 GMT 2025

PRIMARY

WIKIPEDIA

iRGD

Created by admin on Wed Apr 02 15:13:01 GMT 2025 , Edited by admin on Wed Apr 02 15:13:01 GMT 2025

PRIMARY

From	To
1_1	1_9

Related Record Type Details


					U3G09287OR

INTEGRIN ALPHA-V/BETA-5

TARGET->LIGAND

Amount:


					7PF4546T2P

DEGRADENT -> PARENT

Amount:


					1INU2W9JZP

INTEGRIN ALPHA-V/BETA-3

TARGET->LIGAND

Amount:


					SG52LRE3BJ

TARGET -> ACTIVATOR

Comments:

Upon ?V binding, a protease cleavage event is activated, revealing the c-terminal CendR motif (R/KXXR/K). The CendR motif is now able to bind to neuropilin-1, activating an endocytotic/exocytotic transport pathway

Amount:

Related Record Type Details


					Z8MXU5GH4Q

IRGD

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL