U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C17H17NO2
Molecular Weight 267.3224
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETAZEPINE

SMILES

CCOC1C2=CC=CC=C2N(C)C(=O)C3=C1C=CC=C3

InChI

InChIKey=BLGFGFHRMMDRPC-UHFFFAOYSA-N
InChI=1S/C17H17NO2/c1-3-20-16-12-8-4-5-9-13(12)17(19)18(2)15-11-7-6-10-14(15)16/h4-11,16H,3H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C17H17NO2
Molecular Weight 267.3224
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Etazepine (5,6-dihydro-5-methyl-11H-11-ethoxy-dibenzo[b,e]azepin-6-one) demonstrates anticonvulsant activity in rodents. Etazepine seems to exert its anticonvulsant effects by activating the GABAergic system.

CNS Activity

CNS Active
3913
Curator's Comment: Etazepine is CNS active in animals. No human data available.

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Pharmacological profile of the new anticonvulsant etazepine.
1989 Apr
Patents

Patents

20100226943
185
6680047
81
WO2007061529A1
72
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:45:46 GMT 2023
Edited
by admin
on Sat Dec 16 17:45:46 GMT 2023
Record UNII
SBC76K7XWC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETAZEPINE
INN  
INN  
Official Name English
etazepine [INN]
Common Name English
(±)-11-ETHOXY-5,11-DIHYDRO-5-METHYL-6H-DIBENZ(B,E)AZEPIN-6-ONE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C264
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
Code System Code Type Description
INN
5533
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
EPA CompTox
DTXSID10868996
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
EVMPD
SUB07266MIG
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
WIKIPEDIA
Etazepine
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
CAS
88124-27-0
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
MESH
C060314
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
FDA UNII
SBC76K7XWC
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
SMS_ID
100000082391
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
NCI_THESAURUS
C65556
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
PUBCHEM
65662
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106559
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
ECHA (EC/EINECS)
289-386-1
Created by admin on Sat Dec 16 17:45:47 GMT 2023 , Edited by admin on Sat Dec 16 17:45:47 GMT 2023
PRIMARY
Related Record Type Details
Structure of ETAZEPINE, (S)-
ENANTIOMER -> RACEMATE
Structure of ETAZEPINE, (R)-
ENANTIOMER -> RACEMATE
Related Record Type Details
Structure of ETAZEPINE
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966