U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula O2
Molecular Weight 31.9988
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Oxygen

SMILES

O=O

InChI

InChIKey=MYMOFIZGZYHOMD-UHFFFAOYSA-N
InChI=1S/O2/c1-2

HIDE SMILES / InChI

Molecular Formula O2
Molecular Weight 31.9988
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Oxygen is a chemical element with atomic number 8. Diatomic oxygen constitutes 20.8% of the Earth's atmosphere. Diatomic oxygen is used by complex life forms such as animals, in cellular respiration. Medical oxygen is widely used in clinical practice to provide a basis for most modern anaesthetic techniques; to restore the tissue oxygen tension towards normal by improving oxygen availability in a wide range of conditions such as shock, severe haemorrhage, coronary occlusion, carbon monoxide poisoning, major trauma; to aid the resuscitation of the critically ill, when the circulation is impaired; to aid in neonatal resuscitation; to treat acute severe headache in adults diagnosed with cluster headache.

Originator

Curator's Comment: Oxygen was discovered for the first time by a Swedish Chemist, Carl Wilhelm Scheele, in 1772. Joseph Priestly, an English chemist, independently, discovered oxygen in 1774 and published his findings the same year, three years before Scheele published.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Normobaric oxygen is widely recommended for patients with acute myocardial infarction. The randomized phase 3 clinical trial, however, did not demonstrate reduction in 1-year all-cause mortality compared to ambient air group.
Primary
Unknown

Approved Use

Medical oxygen is widely used in clinical practice to provide a basis for most modern anesthetic techniques; to restore the tissue oxygen tension towards normal by improving oxygen availability in a wide range of conditions such as shock, severe hemorrhage, coronary occlusion, carbon monoxide poisoning, major trauma.
Primary
Unknown

Approved Use

Medical oxygen is widely used in clinical practice to treat acute severe headache in adults diagnosed with a cluster headache.
Primary
Unknown

Approved Use

Medical oxygen is widely used in clinical practice to restore the tissue oxygen tension towards normal by improving oxygen availability in a wide range of conditions such as shock, severe hemorrhage, coronary occlusion, carbon monoxide poisoning, major trauma.
PubMed

PubMed

TitleDatePubMed
Dependence of excitotoxic neurodegeneration on mitochondrial aconitase inactivation.
2001 Aug
Recovery from oxidant-mediated lung injury: response of metallothionein, MIP-2, and MCP-1 to nitrogen dioxide, oxygen, and ozone exposures.
2001 Aug
Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase.
2001 Aug 28
Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite.
2001 Dec 21
Sensory nerves promote ozone-induced lung inflammation in mice.
2001 Jul 15
Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells.
2001 Nov
A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses.
2001 Nov
Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment.
2001 Nov
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.
2001 Nov 30
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia.
2001 Sep
Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain.
2001 Sep
Prevention of further cyclophosphamide induced hemorrhagic cystitis by hyperbaric oxygen and mesna in guinea pigs.
2001 Sep
Hypoxia increases leptin expression in human PAZ6 adipose cells.
2002 Apr
Serum SP-D is a marker of lung injury in rats.
2002 Apr
Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia.
2002 Apr 1
The dietary flavonoid quercetin modulates HIF-1 alpha activity in endothelial cells.
2002 Apr 26
NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system?
2002 Aug
Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress.
2002 Aug
Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging.
2002 Aug 30
Increased migration of murine keratinocytes under hypoxia is mediated by induction of urokinase plasminogen activator.
2002 Dec
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets.
2002 Dec
Airway chemotransduction: from oxygen sensor to cellular effector.
2002 Dec 15
Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling.
2002 Dec 15
Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells.
2002 Dec 6
Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth.
2002 Feb 15
Basic toxicological approach has been effective in two poisoned patients with amitraz ingestion: case reports.
2002 Jan
Stabilization of hypoxia-inducible factor-1alpha is involved in the hypoxic stimuli-induced expression of vascular endothelial growth factor in osteoblastic cells.
2002 Jan 7
Oxygen therapy for infants with chronic lung disease.
2002 Jul
Reactive species mediated injury of human lung epithelial cells after hypoxia-reoxygenation.
2002 Jul-Aug
Endothelial nitric oxide synthase lies downstream from angiotensin II-induced angiogenesis in ischemic hindlimb.
2002 Mar 1
Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells.
2002 May
Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis.
2002 May
Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span.
2002 Nov
Hyperbaric oxygen for cyclophosphamide-induced cystitis.
2002 Nov
Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species.
2002 Nov
The role of hypoxia-inducible signaling pathway in nickel carcinogenesis.
2002 Oct
Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.
2002 Oct
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
2002 Oct 25
Retinal oxygen: fundamental and clinical aspects.
2003 Apr
Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxia.
2003 Feb
Suppression of tumor necrosis factor-alpha by beta2-adrenoceptor activation: role of mitogen-activated protein kinases in renal mesangial cells.
2003 Jan
Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1).
2003 Jul
Redox regulation of HIF-1alpha levels and HO-1 expression in renal medullary interstitial cells.
2003 Jun
Induction of T-type calcium channel gene expression by chronic hypoxia.
2003 Jun 20
Use of helium-oxygen mixtures in the treatment of acute asthma: a systematic review.
2003 Mar
Heliox vs air-oxygen mixtures for the treatment of patients with acute asthma: a systematic overview.
2003 Mar
Hyperbaric oxygen for treating wounds: a systematic review of the literature.
2003 Mar
Oxygen administration in infants.
2003 Mar
The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha.
2003 May
Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha.
2003 May 2
Patents

Sample Use Guides

Medical oxygen is administered by inhalation through the lungs. The major exception is when a metered supply is fed into the oxygenator of an extracorporeal circulation of a cardiopulmonary by-pass system. For a cluster headache, oxygen should be administered as soon as possible after the onset of the attack, via a non-rebreathing facemask at a flow of 6 to 12 l/min for approximately 15 minutes.
Route of Administration: Respiratory
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:12:45 GMT 2023
Edited
by admin
on Fri Dec 15 16:12:45 GMT 2023
Record UNII
S88TT14065
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Oxygen
EP   HSDB   INCI   MART.   MI   USP   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
INS NO.948
Code English
OXYGEN [JAN]
Common Name English
OXYGEN [MART.]
Common Name English
OXYGEN [INCI]
Common Name English
OXYGEN [MI]
Common Name English
RNS-60 COMPONENT OXYGEN
Code English
E-948
Code English
OXYGEN [VANDF]
Common Name English
INS-948
Code English
Oxygen [WHO-DD]
Common Name English
OXYGEN [GREEN BOOK]
Common Name English
OXYGEN [WHO-IP]
Common Name English
RNS60 COMPONENT OXYGEN
Code English
OXYGEN [EP MONOGRAPH]
Common Name English
MOLECULAR OXYGEN
Common Name English
OXYGEN [USP MONOGRAPH]
Common Name English
OXYGEN [HSDB]
Common Name English
OXYGENIUM [WHO-IP LATIN]
Common Name English
OXYGEN MOLECULE
Common Name English
DIOXYGEN
Common Name English
Classification Tree Code System Code
LOINC 10236-8
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LOINC 19211-2
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LOINC 10248-3
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JECFA EVALUATION INS-948
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LOINC 10242-6
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LOINC 10233-5
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DSLD 1363 (Number of products:4)
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LOINC 10240-0
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LOINC 2703-7
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WHO-VATC QV03AN01
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LOINC 10245-9
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WHO-ATC V03AN01
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LOINC 2705-2
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LOINC 10239-2
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LOINC 10235-0
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LOINC 10244-2
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WHO-ESSENTIAL MEDICINES LIST 1.1.1
LOINC 10247-5
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LOINC 10232-7
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LOINC 3147-6
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LOINC 3148-4
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LOINC 10241-8
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WHO-ESSENTIAL MEDICINES LIST 1.4
LOINC 10238-4
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LOINC 10234-3
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LOINC 11556-8
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LOINC 10243-4
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LOINC 2706-0
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LOINC 10226-9
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LOINC 10237-6
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LOINC 3149-2
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LOINC 14864-3
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NCI_THESAURUS C1940
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DSLD 1827 (Number of products:15)
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LOINC 28648-4
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LOINC 10246-7
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LOINC 2704-5
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LOINC 28649-2
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Code System Code Type Description
ChEMBL
CHEMBL1234886
Created by admin on Fri Dec 15 16:12:45 GMT 2023 , Edited by admin on Fri Dec 15 16:12:45 GMT 2023
PRIMARY
CAS
7782-44-7
Created by admin on Fri Dec 15 16:12:45 GMT 2023 , Edited by admin on Fri Dec 15 16:12:45 GMT 2023
PRIMARY
SMS_ID
100000090500
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PRIMARY
EPA CompTox
DTXSID2037681
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PRIMARY
RXCUI
7806
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PRIMARY RxNorm
MERCK INDEX
m8333
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PRIMARY Merck Index
MESH
D010100
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PRIMARY
DRUG CENTRAL
4235
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PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
OXYGEN
Created by admin on Fri Dec 15 16:12:45 GMT 2023 , Edited by admin on Fri Dec 15 16:12:45 GMT 2023
PRIMARY Description: A colourless gas; odourless. Solubility: One volume dissolves in about 32 volumes of water and in about 7 volumes of ethanol (~750 g/l) TS, both at apressure of 101.3 kPa and 20?C. Category: Gas for inhalation. Storage: Oxygen should be kept as compressed gas or liquid at cryogenic temperature, in appropriate containers complying withthe safety regulations of the national authority. Valves or taps should not be lubricated with oil or grease. Labelling: An ISO standard1 requires that cylinders containing oxygen intended for medical use should bear the name of thecontents in legible and permanent characters and, preferably, also the molecular formula O2.1 International Standard 32. Gas cylinders for medical use - marking for identification of content. International Organization for Standardization, Switzerland, 1977. Additional information: In the analysis of medicinal gases certain tests are not intended for hospital pharmacists. They are solely applicable by laboratories equipped with the specialized apparatus. Requirements: Oxygen contains not less than 99.5% v/v of O2.
FDA UNII
S88TT14065
Created by admin on Fri Dec 15 16:12:45 GMT 2023 , Edited by admin on Fri Dec 15 16:12:45 GMT 2023
PRIMARY
DAILYMED
S88TT14065
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PRIMARY
ECHA (EC/EINECS)
231-956-9
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PRIMARY
PUBCHEM
977
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PRIMARY
CHEBI
15379
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PRIMARY
NCI_THESAURUS
C722
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PRIMARY
HSDB
5054
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PRIMARY
CHEBI
25805
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PRIMARY
WIKIPEDIA
Triplet oxygen
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PRIMARY
EVMPD
SUB14733MIG
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PRIMARY
DRUG BANK
DB09140
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PRIMARY
Related Record Type Details
LABELED -> NON-LABELED
Related Record Type Details
ACTIVE MOIETY