AZD-4818

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H32Cl2N2O7
Molecular Weight	567.458
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC(=O)C1=C(OC[C@@H](O)CN2CCC3(CC4=CC(Cl)=CC=C4O3)CC2)C=C(OC(C)(C)C(O)=O)C(Cl)=C1

InChI

InChIKey=HVTUHSABWJPWNK-SFHVURJKSA-N

InChI=1S/C27H32Cl2N2O7/c1-26(2,25(34)35)37-23-12-22(19(11-20(23)29)24(33)30-3)36-15-18(32)14-31-8-6-27(7-9-31)13-16-10-17(28)4-5-21(16)38-27/h4-5,10-12,18,32H,6-9,13-15H2,1-3H3,(H,30,33)(H,34,35)/t18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H32Cl2N2O7
Molecular Weight	567.458
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT00629239 | https://www.ncbi.nlm.nih.gov/pubmed/20466530

AZD4818 was developed by AstraZeneca as CCR1 receptor antagonist for the treatment of patients with chronic obstructive pulmonary disease. The study was discontinued, because of a lack of clinical efficacy.

Originator

Approval Year

PubMed

Title	Date	PubMed
Validation of a general in vitro approach for prediction of total lung deposition in healthy adults for pharmaceutical inhalation products.	2013-12	23421897
AZD-4818, a chemokine CCR1 antagonist: WO2008103126 and WO2009011653.	2009-11	19586423

Sample Use Guides

In Vivo Use Guide

Dry Powder, inhalation, b.i.d., 4 weeks

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:38:13 GMT 2025` Edited by `admin` on `Mon Mar 31 20:38:13 GMT 2025`
Record UNII	S5UP6P540K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZD-4818

Common Name

English

AZD4818

Preferred Name

English

2-(2-CHLORO-5-(((2S)-3-(5-CHLORO-2,3-DIHYDROSPIRO(BENZOFURAN-2,4'-PIPERIDIN)-1'-YL)-2-HYDROXYPROPYL)OXY)-4-((METHYLAMINO)CARBONYL)PHENOXY)-2-METHYLPROPANOIC ACID

Systematic Name

English

AZD 4818 [WHO-DD]

Common Name

English

Code System Code Type Description

CAS

1003566-93-5