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Details

Stereochemistry ABSOLUTE
Molecular Formula C27H32Cl2N2O7
Molecular Weight 567.458
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AZD-4818

SMILES

CNC(=O)C1=CC(Cl)=C(OC(C)(C)C(O)=O)C=C1OC[C@@H](O)CN2CCC3(CC4=C(O3)C=CC(Cl)=C4)CC2

InChI

InChIKey=HVTUHSABWJPWNK-SFHVURJKSA-N
InChI=1S/C27H32Cl2N2O7/c1-26(2,25(34)35)37-23-12-22(19(11-20(23)29)24(33)30-3)36-15-18(32)14-31-8-6-27(7-9-31)13-16-10-17(28)4-5-21(16)38-27/h4-5,10-12,18,32H,6-9,13-15H2,1-3H3,(H,30,33)(H,34,35)/t18-/m0/s1

HIDE SMILES / InChI

Molecular Formula C27H32Cl2N2O7
Molecular Weight 567.458
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

AZD4818 was developed by AstraZeneca as CCR1 receptor antagonist for the treatment of patients with chronic obstructive pulmonary disease. The study was discontinued, because of a lack of clinical efficacy.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

Dry Powder, inhalation, b.i.d., 4 weeks
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Sat Dec 16 00:36:45 GMT 2023
Edited
by admin
on Sat Dec 16 00:36:45 GMT 2023
Record UNII
S5UP6P540K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AZD-4818
Common Name English
2-(2-CHLORO-5-(((2S)-3-(5-CHLORO-2,3-DIHYDROSPIRO(BENZOFURAN-2,4'-PIPERIDIN)-1'-YL)-2-HYDROXYPROPYL)OXY)-4-((METHYLAMINO)CARBONYL)PHENOXY)-2-METHYLPROPANOIC ACID
Systematic Name English
AZD 4818 [WHO-DD]
Common Name English
AZD4818
Code English
Code System Code Type Description
CAS
1003566-93-5
Created by admin on Sat Dec 16 00:36:45 GMT 2023 , Edited by admin on Sat Dec 16 00:36:45 GMT 2023
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FDA UNII
S5UP6P540K
Created by admin on Sat Dec 16 00:36:45 GMT 2023 , Edited by admin on Sat Dec 16 00:36:45 GMT 2023
PRIMARY
EPA CompTox
DTXSID30143232
Created by admin on Sat Dec 16 00:36:45 GMT 2023 , Edited by admin on Sat Dec 16 00:36:45 GMT 2023
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ChEMBL
CHEMBL2178570
Created by admin on Sat Dec 16 00:36:45 GMT 2023 , Edited by admin on Sat Dec 16 00:36:45 GMT 2023
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PUBCHEM
24955007
Created by admin on Sat Dec 16 00:36:45 GMT 2023 , Edited by admin on Sat Dec 16 00:36:45 GMT 2023
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DRUG BANK
DB12002
Created by admin on Sat Dec 16 00:36:45 GMT 2023 , Edited by admin on Sat Dec 16 00:36:45 GMT 2023
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SMS_ID
100000174980
Created by admin on Sat Dec 16 00:36:45 GMT 2023 , Edited by admin on Sat Dec 16 00:36:45 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY