AZD-4818

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H32Cl2N2O7
Molecular Weight	567.458
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC(=O)C1=CC(Cl)=C(OC(C)(C)C(O)=O)C=C1OC[C@@H](O)CN2CCC3(CC4=C(O3)C=CC(Cl)=C4)CC2

InChI

InChIKey=HVTUHSABWJPWNK-SFHVURJKSA-N

InChI=1S/C27H32Cl2N2O7/c1-26(2,25(34)35)37-23-12-22(19(11-20(23)29)24(33)30-3)36-15-18(32)14-31-8-6-27(7-9-31)13-16-10-17(28)4-5-21(16)38-27/h4-5,10-12,18,32H,6-9,13-15H2,1-3H3,(H,30,33)(H,34,35)/t18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H32Cl2N2O7
Molecular Weight	567.458
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT00629239 | https://www.ncbi.nlm.nih.gov/pubmed/20466530

AZD4818 was developed by AstraZeneca as CCR1 receptor antagonist for the treatment of patients with chronic obstructive pulmonary disease. The study was discontinued, because of a lack of clinical efficacy.

Originator

Approval Year

PubMed

Title	Date	PubMed
AZD-4818, a chemokine CCR1 antagonist: WO2008103126 and WO2009011653.	2009 Nov	19586423
Validation of a general in vitro approach for prediction of total lung deposition in healthy adults for pharmaceutical inhalation products.	2013 Dec	23421897

Sample Use Guides

In Vivo Use Guide

Dry Powder, inhalation, b.i.d., 4 weeks

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Sat Dec 16 00:36:45 GMT 2023` Edited by `admin` on `Sat Dec 16 00:36:45 GMT 2023`
Record UNII	S5UP6P540K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZD-4818

Common Name

English

2-(2-CHLORO-5-(((2S)-3-(5-CHLORO-2,3-DIHYDROSPIRO(BENZOFURAN-2,4'-PIPERIDIN)-1'-YL)-2-HYDROXYPROPYL)OXY)-4-((METHYLAMINO)CARBONYL)PHENOXY)-2-METHYLPROPANOIC ACID

Systematic Name

English

AZD 4818 [WHO-DD]

Common Name

English

AZD4818

Code

English

Code System Code Type Description

CAS

1003566-93-5