Approval Year
| Substance Class |
Structurally Diverse
Created
by
admin
on
Edited
Sat Dec 16 18:25:05 UTC 2023
by
admin
on
Sat Dec 16 18:25:05 UTC 2023
|
| Source Materials Class | ORGANISM |
| Source Materials Type | ALLOGENIC HUMAN |
| Source Materials State | LIVE GENETICALLY MODIFIED |
| Source Materials Parent | |
| Part | BLOOD |
| Fraction Name | CD4/CD8 T CELLS |
| Record UNII |
S5TX5E9EWP
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Official Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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S5TX5E9EWP
Created by
admin on Sat Dec 16 18:25:06 UTC 2023 , Edited by admin on Sat Dec 16 18:25:06 UTC 2023
|
PRIMARY | |||
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12102
Created by
admin on Sat Dec 16 18:25:06 UTC 2023 , Edited by admin on Sat Dec 16 18:25:06 UTC 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET->ACTIVATOR OF EXPRESSION |
when co-cultured with CD70 expressing cell
IN-VITRO
|
||
|
TARGET->ACTIVATOR OF EXPRESSION |
IN-VITRO
|
||
|
TARGET->CYTOTOXIC T-CELL |
when co-cultured with CD70 expressing cell
IN-VITRO
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
|
Agent Modifications
| Modification Process | Modification Role | Modification Type | Amount | Fragment Name | Fragment ID |
|---|---|---|---|---|---|
| CULTURE | EXPANSION | IMMUNOLOGICAL | INTERLEUKIN-7 HUMAN RECOMBINANT | 418XB47Y71 | |
| GENE EDITING | BIOLOGICAL | EVONCABTAGENE PAZURGEDLEUCEL SINGLE GUIDE RNA (SGRNA) TARGETING THE TRAC LOCUS | FKP72X9XKK | ||
| TRANSFECTION | BIOLOGICAL | VOLAMCABTAGENE DURZIGEDLEUCEL AAV6 VECTOR | K6ECA8WZF8 | ||
| CULTURE | ACTIVATOR | BIOLOGICAL | UNSPECIFIED SUBSTANCE | 4e4ac683 | |
| GENE EDITING | BIOLOGICAL | VOLAMCABTAGENE DURZIGEDLEUCEL SINGLE GUIDE RNA (SGRNA) TARGETING THE CD70 LOCUS | 4M5F9ZC9EH | ||
| GENE EDITING | BIOLOGICAL | EVONCABTAGENE PAZURGEDLEUCEL SINGLE GUIDE RNA (SGRNA) TARGETING THE .BETA.2M LOCUS | EQW8RVL4CV | ||
| CULTURE | EXPANSION | IMMUNOLOGICAL | HUMAN INTERLEUKIN-2 | FNO32LO217 |
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| INSERTED GENE EXPRESSION VECTOR | VOLAMCABTAGENE DURZIGEDLEUCEL TRANSGENE INSERT | PB39U4W7CP | ||||
| VECTOR EXPRESSED PROTEIN | VOLAMCABTAGENE DURZIGEDLEUCEL EXPRESSED N ANTI-CD70 CHIMERIC ANTIGEN RECEPTOR (CAR) | XHL6RF5NTW |