Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H19N3O5S |
| Molecular Weight | 389.426 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12SCC(\C=C\C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C3=CC=C(O)C=C3)C(O)=O
InChI
InChIKey=WDLWHQDACQUCJR-ZAMMOSSLSA-N
InChI=1S/C18H19N3O5S/c1-2-3-10-8-27-17-13(16(24)21(17)14(10)18(25)26)20-15(23)12(19)9-4-6-11(22)7-5-9/h2-7,12-13,17,22H,8,19H2,1H3,(H,20,23)(H,25,26)/b3-2+/t12-,13-,17-/m1/s1
| Molecular Formula | C18H19N3O5S |
| Molecular Weight | 389.426 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Description was created based on several sources, including
http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZKSS200701004.htm | https://www.bmscanada.ca/static/products/en/pm_pdf/CEFZIL_EN_PM.pdf | https://www.ncbi.nlm.nih.gov/pubmed/2232158
Curator's Comment: Description was created based on several sources, including
http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZKSS200701004.htm | https://www.bmscanada.ca/static/products/en/pm_pdf/CEFZIL_EN_PM.pdf | https://www.ncbi.nlm.nih.gov/pubmed/2232158
Cefprozil, an oral cephalosporin antibiotic, is a mixture of antibiotic BMY-28100 (Z- or cis-isomer) and antibiotic BMY-28167 (E- or trans -isomer), the mixture having a Z- to E- isomer ratio in the range of 89:11 to 94:6. BMY-28167 (E- or trans -isomer) is less active when compared with BMY-28100 or isomeric mixture. There were no remarkable differences in the toxicity of the cis isomer, the trans isomer, or cefprozil (the isomeric mixture).
Approval Year
Sample Use Guides
In rats given either cefprozil (cis/trans isomers in a 9:1 ratio), the cis isomer or the trans isomer at
1500 mg/kg/day by oral gavage for one month, alopecia, salivation, reduced body weight in males,
decreased litter weight and increased kidney weight were observed. No clinical pathology or gross or
microscopic pathology was observed.
There were no remarkable differences in the toxicity of the cis isomer, the trans isomer, or cefprozil (the
isomeric mixture) in rats given 1500 mg/kg/day by oral gavage for one month.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:40:22 GMT 2023
by
admin
on
Fri Dec 15 17:40:22 GMT 2023
|
| Record UNII |
S1SDI2FJIY
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
S1SDI2FJIY
Created by
admin on Fri Dec 15 17:40:23 GMT 2023 , Edited by admin on Fri Dec 15 17:40:23 GMT 2023
|
PRIMARY | |||
|
92676-86-3
Created by
admin on Fri Dec 15 17:40:23 GMT 2023 , Edited by admin on Fri Dec 15 17:40:23 GMT 2023
|
PRIMARY | |||
|
m3213
Created by
admin on Fri Dec 15 17:40:23 GMT 2023 , Edited by admin on Fri Dec 15 17:40:23 GMT 2023
|
PRIMARY | Merck Index | ||
|
5281006
Created by
admin on Fri Dec 15 17:40:23 GMT 2023 , Edited by admin on Fri Dec 15 17:40:23 GMT 2023
|
PRIMARY | |||
|
C77188
Created by
admin on Fri Dec 15 17:40:23 GMT 2023 , Edited by admin on Fri Dec 15 17:40:23 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
SOLVATE->ANHYDROUS |
|
||
|
|
SALT/SOLVATE -> PARENT |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
